Jianhua Qu

First Affiliated Hospital of Xinjiang Medical University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Hailong Yuan

Xinjiang Medical University

Nannan Pang

Suzhou Institute of Biomedical Engineering and Technology

Jikui Liu

Peking University Shenzhen Hospital

Zilong Yan

Peking University Shenzhen Hospital

Ming Jiang

Renji Hospital

Shazib Pervaiz

National University Cancer Institute, Singapore

Bing-zhao Wen

Xinjiang Medical University

Xinhong Guo

First Affiliated Hospital of Xinjiang Medical University

Biao Zheng

Guangdong Medical College

Fang Zhao

Shenzhen Third People’s Hospital

Cooperative Institutions

Xinjiang Medical University

First Affiliated Hospital of Xinjiang Medical University

Capital Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking University

Beijing Hospital of Traditional Chinese Medicine

Chinese Academy of Sciences

Shanghai Jiao Tong University

Sun Yat-sen University

Peking University Shenzhen Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Suppression of mitochondrial transcription initiation complexes changes the balance of replication intermediates of mitochondrial DNA and reduces 7S DNA in cultured human cells

The Journal of Biochemistry (2016)

Jianhua Qu Takehiro Yasukawa Dongchon Kang

Journal Article Suppression of mitochondrial transcription initiation complexes changes the balance of replication intermediates of mitochondrial DNA and reduces 7S DNA in cultured human cells Get access Jianhua Qu, Jianhua Qu Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Takehiro Yasukawa, Takehiro Yasukawa * Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan *Takehiro Yasukawa, Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Tel: +81-92-642-5752 , Fax: +81-92-642-5772 , email: ytakehir@cclm.med.kyushu-u.ac.jp Search for other works by this author on: Oxford Academic PubMed Google Scholar Dongchon Kang Dongchon Kang Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 160, Issue 1, July 2016, Pages 49–57, https://doi.org/10.1093/jb/mvw010 Published: 08 February 2016 Article history Received: 17 November 2015 Accepted: 20 January 2016 Published: 08 February 2016

Graduate students

10.1093/jb/mvw010

Cite

Citations (3)

Liangxue Jiedu Runzhi ointment in the treatment of mild and moderate psoriasis with blood-heat syndrome: A double-blind randomized controlled trial

Medicine (2022)

Yue Qiu Weishu Zhang Guanru Li Xinwei Guo Jianhua Qu

Psoriasis is a kind of chronic inflammatory skin disease characterized by erythema, skin hyperplasia, scales and keratinocyte hyperproliferation. Psoriasis Vulgaris, the most common kind of psoriasis, severely deteriorates the life quality of patients. Traditional Chinese Medicine (TCM) is a good choice for the treatment of psoriasis, which has been proved to be safe and effective, and may reduce the recurrence rate. In clinical practice, Liangxue Jiedu Runzhi (LJR) ointment can effectively treat mild and moderate psoriasis with blood-heat syndrome, but there is a lack of evidence-based medical evidence. This trial aims to evaluate the efficacy and safety of LJR ointment for the treatment of mild and moderate psoriasis with blood-heat syndrome.A multicenter, randomized, double-blind, placebo-controlled, and self-controlled clinical trial was carried out according to this paper. The symmetrical rashes of each subject were regarded as the target lesions and were randomly divided into a treatment group (LJR ointment group) and a control group (placebo group). The LJR ointment or placebo ointment were externally administered on bilateral symmetric rashes, twice a day for eight weeks. The follow-up examination was made for subjects every two weeks. The primary research finding was conveyed by Psoriasis Area and Severity Index (PASI) in 8 weeks. The secondary research finding includes adverse events.46 subjects undergo this research project. The difference between PASI scores of the target lesions in the treatment group and control group is statistically significant were in 8 weeks (P < .001). The percentage of PASI 75 in treatment group and control group were 48% and 15% in week 8, respectively (x2 = 11.33, P < .05). No severe adverse events were reported.LJR ointment was proved to have efficacy in the treatment of mild and moderate psoriasis with the blood-heat syndrome.

Erythema

10.1097/md.0000000000031784

Cite

Citations (0)

Identification of key genes and miRNA-mRNA regulatory networks associated with bone marrow immune microenvironment regulations in multiple myeloma by integrative bioinformatics analysis

Figshare (2022)

Niluopaer Tuerxun Jie Wang Yuting Qin Fang Zhao Huan Wang

The deregulation of microRNAs (miRNAs) and genes in the bone marrow microenvironment have been involved with the pathogenesis of multiple myeloma (MM). However, the exploration of miRNA-mRNA regulatory networks in MM remains lacking. We used GSE125363, GSE125361, GSE47552, GSE2658, GSE136324, GSE16558, and GSE13591 datasets for this bioinformatics study. We identified 156 downregulated and 13 upregulated differentially expressed miRNAs (DEmiRs) in MM. The DEmiRs are associated with the enrichment of pathways mainly involved with cancers, cellular signaling, and immune regulations. We identified 112 hub genes associated with five significant clusters in MM. Moreover, we identified 9 upregulated hub genes (such as IGF1, RPS28, UBA52, CDKN1A, and CDKN2A) and 52 downregulated hub genes (such as TP53, PCNA, BRCA1, CCNB1, and MSH2) in MM that is targeted by DEmiRs. The expression of DEmiRs targeted two hub genes (CDKN2A and TP53) are correlated with the survival prognosis of MM patients. Furthermore, the expression level of CDKN2A is correlated with immune signatures, including CD4+ Regulatory T cells, T cell exhaustion, MHC Class I, immune checkpoint genes, macrophages, neutrophils, and TH2 cells in the TME of MM. Finally, we revealed the consistently deregulated expression level of key gene CDKN2A and its co-regulatory DEmiRs, including hsa-mir-192, hsa-mir-10b, hsa-mir-492, and hsa-mir-24 in the independent cohorts of MM. Identifying key genes and miRNA-mRNA regulatory networks may provide new molecular insights into the tumor immune microenvironment in MM.

Identification

10.6084/m9.figshare.19740482

Cite

Citations (0)

Let-7c inhibits metastatic ability of mouse hepatocarcinoma cells via targeting mannoside acetylglucosaminyltransferase 4 isoenzyme A

The International Journal of Biochemistry & Cell Biology (2014)

Yanjie Guo Sheng Li Jianhua Qu Lin Ye Shujing Wang

10.1016/j.biocel.2014.04.012

Cite

Citations (14)

A Novel Surrogate-Assisted Multi-Objective Well Control Parameter Optimization Method Based on Selective Ensembles

Processes (2024)

Wang Lian Rui Deng Liang Zhang Jianhua Qu Hehua Wang

Multi-objective optimization algorithms are crucial for addressing real-world problems, particularly with regard to optimizing well control parameters, which are often computationally expensive due to their reliance on numerical simulations. Surrogate-assisted models help to reduce this computational burden, but their effectiveness depends on the quality of the surrogates, which can be affected by candidate dimension and noise. This study proposes a novel surrogate-assisted multi-objective optimization framework (MOO-SESA) that combines selective ensemble support-vector regression with NSGA-II. The framework’s uniqueness lies in its adaptive selection of a diverse subset of surrogates, established prior to iteration, to enhance accuracy, robustness, and computational efficiency. To our knowledge, this is the first instance in which selective ensemble techniques with multi-objective optimization have been applied to reservoir well control problems. Through employing an ensemble strategy for improving the quality of the surrogate model, MOO-SESA demonstrated superior well control scenarios and faster convergence compared to traditional surrogate-assisted models when applied to the SPE10 and Egg reservoir models.

Surrogate model

Robustness

10.3390/pr12102140

Cite

Citations (1)

Reconstitution and clinical significance of T cell subsets in the early stage after related HLA-mismatched peripheral blood hematopoietic SCT without T-cell depletion in vitro.

PubMed (2015)

Nannan Pang Xianlin Duan Ming Jiang Jianhua Qu Hailong Yuan

Related HLA-haploidentical HSCT has been applied more and more recently, but the reconstitution of T lymphocyte subsets and its clinical significance in patients received related HLA-haploidentical non T-cell depleted in vitro high-dose peripheral blood hematopoietic SCT (RHNT-PSCT) are incompletely defined. In the present study of our RHNT-PSCT, we found that in non-aGVHD group, CD3(+) T lymphocyte recovered to normal levels gradually between 60 and 90 days, and the recovery of CD4(+) T lymphocyte was retarded significantly, CD4(+)/CD8(+) ratio was apparently inverted. Whereas, the ratio of CD4(+) CD25(+) Foxp3(+) Treg cells was significantly lower in aGVHD group than in healthy control group and non-aGVHD group, and also in grade III-IV aGVHD patients than in grade I-II aGVHD patients. Meanwhile, we observed the level of interleukin-10 (IL-10) gradually increased in serum of patients without aGVHD, but decreased in III-IV aGVHD patients significantly. Spearman correlation analysis showed that serum IL-10 level was negatively correlated with the grade of aGVHD. These results suggest that the reconstitution of peripheral blood T lymphocyte subsets is good, and dynamic detection of Treg cells and serum IL-10 level might predict aGVHD in the early stage after our RHNT-PSCT.

Clinical Significance

Source

Cite

Citations (9)

[Analysis of the therapeutic efficacy and prognosis for acute myeloid leukemia M2a patients treated by IA and DA regimens].

PubMed (2014)

Fan Wang Hailong Yuan Xianlin Duan Lei Wang Haizhou Cao

This study was purposed to compare the therapeutic efficacy and prognosis of acute myeloid leukemia M2a (AML-M2a) patients treated by idarubicin (IDA) combined with cytarabine (Ara-C) (IA) and daunorubicin (DNR) combined cytarabine (Ara-C) (DA) regimens. The clinical data of 65 patients with AML-M2a in our hospital were collected from May 2009 to May 2013 and analyzed. The results indicated the complete remission in IA group was slightly higher than that in DA group, there was no statistically significant difference(P > 0.05); leukocyte minimum value in IA group [(0.58 ± 0.40)×10(9)/L] was obviously lower than that in DA group [(0.99 ± 0.67)×10(9)/L] (P < 0.05); neutrophil minimum value in IA group [(0.19 ± 0.09)×10(9)/L] was significantly lower than that in DA group [(0.21 ± 0.16)×10(9)/L] (P < 0.05); the neutropenia duration in IA group (12.59 ± 5.31)d was much longer than that in DA group (9.17 ± 7.04)d (P < 0.05). The median survival time of patients in IA group was 36.67 months, which was obviously longer than that of patients in DA group (21.45 months) (P < 0.05). The lactate dehydrogenase (LDH) value and chemotherapy regimens were the independently risk factor affecting the prognosis of AML-M2a patients. It is concluded that as compared with DA regimen, the IA regimen can prolong the median survival time and has better long-term therapeutic efficacy, thus it can be used as the first chemotherapy regimen for treatment of AML-M2a.

Idarubicin

Daunorubicin

Regimen

Therapeutic effect

10.7534/j.issn.1009-2137.2014.04.017

Cite

Citations (0)

Study on the expression of PAK4 and P54 protein in breast cancer

World Journal of Surgical Oncology (2016)

Yanqing Bi Mengzi Tian Jinghong Le Linlin Wang Xiaofang Liu

Previous evidence have demonstrated that p21-activated kinase PAK4 was correlated with breast cancer. The aim of this paper is to study the expression and interaction of p21-activated kinase (pAK)-4 and P54 protein in breast cancer.A total of 80 patients were enrolled in our study (breast fibroma n = 20, breast noninvasive cancer n = 20, early breast invasive cancer n = 20, and advanced breast invasive cancer). The expression of PAK4 was detected by immunohistochemical S-P method, and the relationship between them and the different pathological characteristics were compared. The subcellular localization of P54 and PAK4 in vitro was observed by immunofluorescence assay.The expression of both PAK4 and P54 in breast cancer was much higher than that in breast fibroma. Meanwhile, we found that both PAK4 and P54 increased gradually as breast cancer progressed (advanced invasive > early invasive > noninvasive). The positive staining of P54 were mainly located in the cytoplasm, especially around the nucleus. There was no significant stained region in the cell matrix. The P54 localization in the cytoplasm was verified by confocal experiment, and the PAK4 was co-localized.PAK4 and P54 proteins may be used as molecular markers for diagnosis and treatment of breast cancer.

Surgical oncology

Immunofluorescence

10.1186/s12957-016-0913-6

Cite

Citations (23)

[Comparisons of occurrence and curative effect of interstitial pneumonia after the related HLA-haploidentical and HLA-matched sibling peripheral blood hematopoietic stem cell transplantation].

PubMed (2016)

X Y Wang Ming Jiang Jianhua Qu X L Duan Hailong Yuan

To compare occurrence and curative effect of interstitial pneumonia (IP) of patients with malignant hematologic disease after related HLA-haploidentical peripheral blood stem cell transplantation without T-cell depletion (RHNT-PBSCT) and non T cell-depleted HLA-matched sibling peripheral blood stem cell transplantation (MSNT-PBSCT).109 patients with malignant hematologic disease as the research cases received RHNT-PBSCT from January 2006 to December 2014, which were compared with 125 patients treated with MSNT-PBSCT during the same period to determine the occurrence of IP and curative effect produced by ganciclovir and joint adrenal glucocorticoids.The incidences of IP in RHNT-PBSCT and MSNT-PBSCT groups were 15.60%(17/109) and 13.60%(17/125) (P=0.150), respectively; both the effective rates were 76.47%(13/17) (P=0.536), the difference was not statistically significant. Single factor analysis showed that acute graft versus host disease was a risk factor for the occurrence of IP after RHNT-PBSCT (P=0.001).The incidence of IP in patients with malignant hematologic disease after RHNT-PBSCT didn' t increase when compared with patients after MSNT-PBSCT. The curative effects of the two groups were equivalent after priority to ganciclovir and joint adrenal glucocorticoids.

10.3760/cma.j.issn.0253-2727.2016.06.003

Cite

Citations (0)

Effect of serum from healthy individuals on the growth of melanocytesin vitrofollowing moxibustion at the “Jiudianfeng” point

Journal of International Medical Research (2020)

Rupeng Liu Tianhui Niu Yu Cheng Dongmei Zhou Cang Zhang

ObjectiveTo investigate the effects of serum from healthy individuals obtained following moxibustion at the “Jiudianfeng” point on melanocytes in vitro. MethodsTen healthy adults (five male and five female) were treated by moxibustion at the “Jiudianfeng” point for 30 minutes once daily for 3 months. The effects of treatment with serum obtained following moxibustion on melanocyte proliferation, melanin content, tyrosinase activity, cell cycle progression, and c-kit mRNA and protein expression were assessed in vitro before and after moxibustion for 1, 2, and 3 months. ResultsExposure to sera from healthy adults following moxibustion therapy promoted melanocyte proliferation, melanin synthesis, tyrosinase activity, and c-kit mRNA and protein expression in vitro. Melanin synthesis and tyrosinase activity increased in the first 2 months following moxibustion and a synchronous decline was observed during the third month. Serum also promoted melanocyte entry into the G1 phase of the cell cycle. ConclusionsSerum treatment following moxibustion at the “Jiudianfeng” point promoted melanocyte proliferation and melanin synthesis. Further exploration of this intriguing phenomenon is essential.

Moxibustion

Melanocyte

10.1177/0300060520910667

Cite

Citations (0)