To report the case of a 28-year-old patient with persistent bilateral burning pain and foreign body sensation in both eyes for the past 1 year. The patient showed a poor response to 0.05% cyclosporine eye drops and frequent instillations of artificial tears. Ocular examination showed few superficial punctate epithelial defects, well-positioned laser in situ keratomileusis (performed 5 years ago with symptomless recovery) flaps, and clear interfaces bilaterally, with a tear film breakup time of 7 and 8 seconds in the right and left eyes, respectively. The results of Schirmer tests, confocal microscopy, corneal esthesiometry, and meibography were normal for both eyes. The patient was incidentally diagnosed with vitamin B12 deficiency, with a serum vitamin B12 value of 90 pg/mL (reference range, 236-911 pg/mL), during routine laboratory tests. In view of weak correlation between signs and symptoms, a putative diagnosis of ocular neuropathic pain secondary to vitamin B12 deficiency was made.Case report.The patient was treated with parenteral vitamin B12, and topical therapy was continued without any changes. The patient experienced dramatic improvement with a decrease in symptoms within 3 weeks of administering vitamin B12 supplements and was symptom-free in the absence of any topical medication 6 months after treatment.Vitamin B12 deficiency, although common in India, has not been reported to be associated with ocular symptoms, including pain and mimicking those seen in severe dry eye. Vitamin B12 deficiency should be considered in the differential diagnosis of ocular neuropathic pain and dry eye in patients presenting with recalcitrant ocular neuropathic pain.
The main aim of this review is to update the reader with practical knowledge concerning the relationship between diabetes mellitus and periodontal diseases. Exclusive data is available on the association between these two chronic diseases till date. Articles published on this relationship often provide the knowledge of definitions of diabetes mellitus and periodontal diseases, prevalence, extent, severity of periodontal disease, complications of diabetes along with the possible underlying mechanisms. The authors reviewed human epidemiological studies, cross-sectional observations and longitudinal cohort, case control that evaluated variables exclusively over the past 30 years and the predominant findings from the "certain" articles are summarized in this review. This review clarifies certain queries such as 1) Do periodontal diseases have an effect on the metabolic control of diabetes? 2) Does diabetes act as a risk factor of periodontitis? 3) What are the possible underlying mechanisms relating the connection between these two chronic diseases? 4) What is the effect of periodontal intervention on metabolic control of diabetes? After a thorough survey of literature, it was observed that diabetes acts as a risk factor in development of periodontitis as periodontitis is significantly aggravated in patients suffering from diabetes having long term hyperglycemia. Different mechanisms underlying the association between the accelerated periodontal disease and diabetes are emerging but still more work is required. Major efforts are required to elucidate the impact of periodontal diseases on diabetes. At the same time, patients are needed to be made aware of regular periodontal maintenance schedule and oral hygiene.
Dry eye disease (DED) has evolved into a major public health concern with ocular discomfort and pain being responsible for significant morbidity associated with DED. However, the etiopathological factors contributing to ocular pain associated with DED are not well understood. The current IVCM based study investigated the association between corneal dendritic cell density (DCD), corneal subbasal nerve plexus (SBNP) features, and serum vitamin D and symptoms of evaporative dry eye (EDE). The study included age and sex matched 52 EDE patients and 43 heathy controls. A significant increase in the OSDI scores (discomfort subscale) was observed between EDE (median, 20.8) and control (median, 4.2) cohorts (P < 0.001). Similarly, an increase in DCD was observed between EDE (median, 48.1 cells/mm(2)) patients and controls (median, 5.6 cells/mm(2)) (P < 0.001). A significant decrease in SBNP features (corneal nerve fiber length, fiber density, fiber width, total branch density, nerve branch density, and fiber area) was observed in EDE patients with OSDI score >23 (P < 0.05). A positive correlation was observed between DCD and OSDI discomfort subscale (r = 0.348; P < 0.0003) and SBNP features. An inverse correlation was observed between vitamin D and OSDI scores (r = -0.332; P = 0.0095) and DCD with dendritic processes (r = -0.322; P = 0.0122). The findings implicate DCD, SBNP features, and vitamin D with EDE symptoms.
Purpose: To study the factors causing cap lenticular adhesion (CLA), a rare complication of small incision lenticule extraction (SMILE) surgery, and its effect on surgical outcomes. Design: A prospective, observational, cross-sectional study involving 550 eyes of 285 subjects. Methods: SMILE was performed using the VisuMax femtosecond laser (Carl Zeiss Meditec, Jena, Germany) with a minimum of 3 months follow-up. Preoperative visual quality assessment, measurement of corneal biomechanics, and Bowman membrane imaging were performed. Based on the mean refractive spherical equivalent (MRSE), subjects were classified into mild, moderate, and high myopes. Causes of CLA and postoperative outcomes were evaluated. Results: CLA was seen in 1.8% of patients, in whom the median preoperative MRSE was −1.5 (−2.75 to −1.38), deformation amplitude was 1.13 (1.10 to 1.21), and lenticular thickness was 46.2 (39.9 to 54.31). They had microdistortions in the Bowman layer and poor quality of vision. A median Strehl ratio of 0.08 (0.07 to 0.11) and modulation transfer function of 9.88 (8.98 to 13.34) were noted on the first day after surgery, which gradually improved to 0.17 (0.15 to 0.18) and 33.90 (27.27 to 38.94), respectively. On observing the surgical videos, a distinct shining reflection, “the shimmer sign,” was seen around the dissector in patients with CLA when the posterior plane was dissected before the anterior. Conclusions: Cap lenticular adhesion was associated with a low preoperative MRSE and thin lenticules. The shimmer sign serves as an indicator for identification of the correct plane of dissection.
Migraine is a multifactorial disorder with complex neuronal and vascular mechanisms that encompasses a wide clinical spectrum of symptoms, including ocular manifestations. Dry eye disease and dysfunction of ocular somatosensory pathways have been implicated in the pathogenesis. The current study investigates the association between a dysfunctional tear film and ocular aberrations with migraine.Sixty eyes of 30 patients with migraine and 60 eyes of 30 controls were studied. Dry eye evaluation included Schirmer's test, tear film break-up time, corneal esthesiometry and lipid layer analysis using Lipiview® interferometer. Wavefront aberrations were measured using Optical Path Difference before performing the dry eye evaluation. The intraocular light scatter was quantified using the objective scatter index (OSI) of the optical quality analysis system. Measured parameters were compared between the migraine and the control group using independent sample t-test. Statistical analysis was performed using commercial software. A p value of ≤ 0.05 was considered statistically significant.There were 19 females and 11 males in each group. Statistically significant difference was found between the two groups with respect to total aberrations (p = 0.049), higher order aberrations (p = 0.009), coma (p = 0.03), spherical aberrations (p = 0.018), Lipiview interferometric coloric units (p < 0.001) and OSI (p < 0.001). Trefoil (p = 0.26) and TBUT (p = 0.398) were not significantly different between both groups.Ocular aberrations are higher in patients with migraine as compared with controls. Tear film abnormalities add to the aberrations in otherwise asymptomatic patients and may also be associated with migraineous attacks. Treating the ocular surface to obtain a healthy tear film might introduce a potential modifiable factor in the prevention of migraneous attacks.
To study the association between corneal deformation (CD) and ease of lenticule separation from the stroma in small incision lenticule extraction.Thirty-six myopic eyes of 36 patients underwent small incision lenticule extraction. Preoperative refraction, intraocular pressure, central corneal thickness, and CD were evaluated with Scheimpflug imaging and air-puff applanation. Fourier transform of CD waveform was also performed. The surgeon also graded the ease of separation of lenticule surfaces from the residual stroma intraoperatively as grades 1 (low effort), 2 (moderate effort), and 3 (high effort). All the procedures were performed by the same surgeon. CD values were concealed from the surgeon. Differences between the grades were assessed with 1-way analysis of variance and analysis of covariance.Mean preoperative refraction, intraocular pressure, central corneal thickness, lenticule thickness, and incision width were similar among the grades (P > 0.05). A total of 5 of the 10 analyzed CD variables were significantly different among the grades. Among them, deformation amplitude (1.20 vs. 1.13 vs. 1.07 mm in the order of increasing grades, P = 0.001), velocity of the corneal apex at the second applanation point (-0.47 vs. -0.43 vs. -0.40 m/s, P = 0.02), peak distance (5.33 vs. 5.25 vs. 5.07 mm, P = 0.006), area under the deformation amplitude (13.40 vs. 12.84 vs. 12.06, P = 0.04), and root mean square of Fourier coefficients (0.12 vs. 0.12 vs. 0.11 mm, P = 0.005) decreased from grades 1 to 3.CD was inversely correlated with the ease of lenticule separation from the residual stroma and may assist in customization of the energy parameters of the laser.
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