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Marie Bourgeois

Hôpital Necker-Enfants Malades

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Christian Sainte‐Rose

Centre Hospitalier Régional et Universitaire de Nancy

Thomas Blauwblomme

Hôpital Necker-Enfants Malades

Nathalie Boddaert

Assistance Publique – Hôpitaux de Paris

Michel Zérah

Hôpital Necker-Enfants Malades

Françis Brunelle

Assistance Publique – Hôpitaux de Paris

Kévin Beccaria

Assistance Publique – Hôpitaux de Paris

Raymond D. Harbison

University of South Florida

Federico Di Rocco

Inserm

Syril James

Assistance Publique – Hôpitaux de Paris

Giovanna Paternoster

Assistance Publique – Hôpitaux de Paris

Cooperative Institutions

Inserm

Assistance Publique – Hôpitaux de Paris

Université Paris Cité

Hôpital Necker-Enfants Malades

Centre National de la Recherche Scientifique

Lille Inflammation Research International Center

Service de la Santé Publique

Sorbonne Paris Cité

Centre Hospitalier Universitaire Amiens-Picardie

Sorbonne Université

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Benign cerebellar astrocytomas in children

Journal of neurosurgery (1999)

Philippe Pencalet Wirginia Maixner Christian Sainte‐Rose Arielle Lellouch‐Tubiana Giuseppe Cinalli

Cerebellar astrocytomas are benign tumors of childhood known to be associated with excellent long-term survival in patients in whom complete surgical resection is possible. However, the roles of other factors--clinical, radiological, histological, and therapeutic--in the survival of the patient, tumor recurrence, and long-term patient outcome remain imprecise. The goal of this study was to examine these factors and their relationships.To clarify these issues a retrospective review was conducted of 168 children who were surgically treated for a cerebellar astrocytoma at Hôpital Necker-Enfants Malades between 1955 and 1995. These patients' clinical files were examined, the histological characteristics of their tumors were reviewed, and their outcomes were assessed according to Bloom's scale and the Wechsler intelligence quotient test. Of the 168 patients in the study, 91 were male and 77 were female with a mean age of 6.9 years and a mean follow up lasting 7.7 years. Tumors were identified as being strictly located in the cerebellum in 76.2% of the patients and as involving the brainstem (referred to as the "transitional form") in 23.8% of the patients. Complete surgical excision was possible in 88.7% of cases. There was a total mortality rate of 4.2% and a tumor recurrence rate of 9.5%. Fifty-eight percent of the patients had no neurological sequelae at follow-up evaluation. Pejorative factors that were discovered by multivariate analysis to be important included: a long preoperative duration of symptoms and the transitional form of tumor with respect to survival; incomplete tumor excision with respect to an increased risk of recurrence; and a long preoperative duration of symptoms, an early epoch during which surgery was performed (1955-1974), severe ventricular dilation, and the transitional form of tumor with respect to a poorer long-term patient outcome.The presence of brainstem involvement (tumor in the transitional form) emerged as a significant negative prognostic factor and should be treated as a distinct nosological entity. The extent of surgical excision has a significant bearing on the risk of tumor recurrence.

10.3171/jns.1999.90.2.0265

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Citations (151)

[What is biological psychiatry?].

Marie Bourgeois

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Citations (1)

Preclinical Testing of Chronic ICA-1S Exposure: A Potent Protein Kinase C-ι Inhibitor as a Potential Carcinoma Therapeutic

Drugs and Drug Candidates (2024)

Christopher Apostolatos Wishrawana S. Ratnayake Sloan Breedy Jacqueline Kai Chin Chuah James Alastair Miller

Protein kinase C-iota (PKC-ι) is an oncogene overexpressed in many cancer cells including prostate, breast, ovarian, melanoma, and glioma cells. Previous in vitro studies have shown that 5-amino-1-((1R,2S,3R,4R)-2-3-dihydroxy-4-(hydroxymethyl)cyclopentyl)-1H-imidazole-4-carboxamide (ICA-1S), a PKC-ι-specific inhibitor, has low toxicity in both acute and sub-acute mouse model toxicological testing and is an effective therapeutic against several cancer cell lines showing significant reductions in tumor growth when treating athymic nude mice with xenografted carcinoma cell lines. To further assess ICA-1S as a possible therapeutic agent, chronic mouse model toxicological testing was performed in vivo to provide inferences concerning the long-term effects and possible health hazards from repeated exposure over a substantial part of the animal’s lifespan. Subjects survived well after 30, 60, and 90 days of doses ranging from 50 mg/kg to 100 mg/kg. Heart, liver, kidney, and brain tissues were then analyzed for accumulations of ICA-1S including the measured assessment of aspartate transaminase (AST), alkaline phosphatase (ALK-P), gamma-glutamyl transferase (GGT), troponin, and C-reactive protein (CRP) serum levels to assess organ function. Predictive in vitro/in silico methods were used to predict compound-induced direct hepatocyte toxicity or renal proximal tubular cell (PTC) toxicity in humans based on the high-content imaging (HCI) of compound-treated cells in combination with phenotypic profiling. In conclusion, ICA-1S shows low toxicity in both acute and chronic toxicology studies, and shows promise as a potential therapeutic.

10.3390/ddc3020022

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Reduced oxygen tension culturing conditionally alters toxicogenic response of differentiated H9c2 cardiomyoblasts to acrolein

Toxicology Mechanisms and Methods (2018)

Jayme P. Coyle Robert Rinaldi Giffe T. Johnson Marie Bourgeois James D. McCluskey

Acrolein is a reactive electrophilic aldehyde known to cause mitochondrial dysfunction, oxidative stress, and dysregulation of signaling transduction in vitro. Most in vitro systems employ standard cell culture maintenance conditions of 95% air/5% CO2, translating to a culture oxygen tension of approximately 20%, far above most physiological tissues. The purpose of this investigation was to examine whether low-serum, retinoic acid differentiated H9c2 cells were less sensitive to acrolein insult when cultured under reduced oxygen tension. H9c2 cells were maintained separately in 20% and 5% oxygen, differentiated for 5 d, and then exposed to acrolein for 30 min in media containing varying concentrations of tricarboxylic acid and glycolytic substrates, followed by fresh medium replacement. Cells were then assessed for MTT reduction at 2 h and 24 h after acrolein insult. We showed that pyruvate supplementation in combination with lowered oxygen culturing significantly attenuated acrolein-induced viability loss at 24 h. Poly(ADP-ribose) polymerase inhibition and EGTA preferentially provided partial rescue to low oxygen cultures, but not for standard cultures. Collectively, these results offer evidence supporting altered toxicogenic response of H9c2 during physiologically relevant oxygen tension culturing.

Acrolein

Oxygen tension

Viability assay

10.1080/15376516.2018.1455785

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Functional cortico-subcortical reorganization after complete hemispheric disconnection for intractable epilepsy

bioRxiv (Cold Spring Harbor Laboratory) (2019)

Thomas Blauwblomme Athéna Demertzi Jean-Marc Tacchela Ludovic Fillon Marie Bourgeois

Abstract Hemispherotomy is a treatment for drug-resistant epilepsy with the whole hemisphere involved in seizure onset. As recovery mechanisms are still debated, we characterize functional reorganization with multimodal MRI in two children operated on the right hemisphere (RH). We found that interhemispheric functional connectivity was abolished in both patients. The healthy left hemispheres (LH) displayed focal hyperperfusion in motor and limbic areas, and preserved network-level organization. The disconnected RHs were hypoperfused despite sustained network-level organization. Functional connectivity was increased in the left thalamo-cortical loop and between the cerebelli. The classification probability of the RH corresponding to a minimally conscious state was smaller than for the LH. We conclude that after hemispherotomy, neurological rehabilitation is sustained by cortical disinhibition and reinforcement of connectivity driven by subcortical structures in the remaining hemisphere. Our results highlight the effect of vascularization on functional connectivity and raise inquiries about the conscious state of the isolated hemisphere.

Disinhibition

Disconnection

Right hemisphere

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[Psychiatry and the control of procreation].

Marie Bourgeois

Sterilization

Human reproduction

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[Treatment of opiate weaning by clonidine in prison (evaluation based on 36 patients)].

P Rager Michel Bénézech Marie Bourgeois E. Magot-Magnien

Detoxification

Opiate

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Assessment of lead exposure controls on bridge painting projects using worker blood lead levels

Regulatory Toxicology and Pharmacology (2020)

Kevin Guth Marie Bourgeois Giffe T. Johnson Raymond D. Harbison

Lead (geology)

Blood lead level

Bridge (graph theory)

10.1016/j.yrtph.2020.104698

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Citations (8)

Abusive Head Trauma in Infants During the COVID-19 Pandemic in the Paris Metropolitan Area

JAMA Network Open (2022)

Alina-Marilena Lãzãrescu Sandro Benichi Thomas Blauwblomme Kévin Beccaria Marie Bourgeois

The COVID-19 pandemic and the containment and mitigation measures taken were feared to be associated with increased child abuse.

10.1001/jamanetworkopen.2022.26182

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Citations (20)

Factors influencing the complication rate of subduroperitoneal shunt placement for the treatment of subdural hematomas in infants

Journal of Neurosurgery Pediatrics (2007)

Senta Kurschel Stéphanie Puget Marie Bourgeois Michel Zérah Petra Ofner

In this study the authors' goal was to identify the complication rate of subduroperitoneal (SDP) shunts for the treatment of subdural hematomas (SDHs) in infants and to determine the influences on and predictive factors for these complications.The authors present a case series spanning the years 1994 to 2003 and include a statistical analysis of 161 children 2 years of age or younger with SDH who were treated using a unilateral valveless SDP shunt. The patient history, characteristics, and treatment methods including prior therapies, neuroimaging findings, and clinical outcomes were measures of evaluation. Thirty-six children (22.4%) suffered complications related to SDP shunts: obstruction in 27 (16.8%), infections in eight (5%), disconnection in four (2.5%), migration in three (1.9%), wound complications (leakage and skin ulceration) in two (1.2%), and symptomatic subdural rebleeding in one (0.6%) necessitating bur hole evacuation. Seventeen children (10.6%) underwent placement of a second SDP shunt because of ipsilateral or contralateral persistent fluid collections, or premature shunt removal. With the exception of 12 patients (7.4%), shunt removal was performed systematically and resulted in the following minor complications in 30 children (18.6%): an adherent proximal catheter in 16 (9.9%), transient symptoms of intracranial hypertension in six (3.7%), subcutaneous cerebrospinal fluid accumulation in four (2.5%), local infections in three (1.9%), and hydrocephalus requiring placement of a ventriculoperitoneal shunt in one (0.6%). Status epilepticus at presentation and neuroimaging findings such as areas of hyperdensity on computed tomography (CT) scans representing fresh blood in the subdural fluid collections before shunt insertion and at follow up were predictors of shunt-related complications. Correlations were also discovered for the following CT findings: ischemic lesions before shunt treatment, cerebral atrophy and ventricular dilation during the last follow up, and residual medium to large collections before shunt removal. Children who attained a good outcome were less affected by shunt-related complications, unlike those who presented with focal deficits and/or visual impairment.Subduroperitoneal shunt placement for the treatment of SDH in infants is--despite the complication rate--an effective and often inevitable treatment option, especially for most large and symptomatic SDHs; a certain number of complications could be reduced with careful and precise surgical techniques. Close observation for detection of risks is mandatory, and seizure control is essential to prevent further brain injury that may result in large subdural fluid collections that are difficult to treat.

10.3171/ped.2007.106.3.172

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Citations (15)