Hanyiqi Mu

The Seventh Affiliated Hospital of Sun Yat-sen University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Xiaoyue Wei

Hua Medicine (China)

Ziyuan Zhang

Zhengzhou University

Yifei Ru

Sun Yat-sen University

Qinmu Zhang

Sun Yat-sen University

Yanchen Ye

The First Affiliated Hospital, Sun Yat-sen University

Zhuangling Lin

Sun Yat-sen University

Yuan Ma

Sun Yat-sen University

Kunbei Lai

Sun Yat-sen University

Yuanyuan Feng

Shanghai University of Traditional Chinese Medicine

Xinxiang Wu

Sun Yat-sen University

Cooperative Institutions

Sun Yat-sen University

The Seventh Affiliated Hospital of Sun Yat-sen University

Zhongshan Hospital

Army Medical University

The First Affiliated Hospital, Sun Yat-sen University

Jinan University

Ningxia Medical University

East China Normal University

Capital Medical University

Xi'an Jiaotong University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

iPSCs-derived mesenchymal stromal cells mitigate anxiety and neuroinflammation in aging female mice

The International Journal of Biochemistry & Cell Biology (2022)

Xiaoyue Wei Ruijie Li Xiangyu Li Boyan Wang Jianyang Huang

10.1016/j.biocel.2022.106347

Cite

Citations (4)

Mesenchymal Stromal Cells Act as Biopatches for Blood–Retinal Barrier Preservation to Enhance Functional Recovery after Retinal Ischemia/Reperfusion

Molecular Therapy — Nucleic Acids (2025)

Xiaoyue Wei Hanyiqi Mu Qinmu Zhang Ziyuan Zhang Yifei Ru

Retinal ischemia/reperfusion (I/R) is one of the most common pathologies of many vision-threatening diseases and is caused by blood-retinal barrier (BRB) breakdown and the resulting inflammatory infiltration. Targeting BRB is promising for retinal I/R treatment. Mesenchymal stromal cells (MSCs) are emerging as novel therapeutic strategies. Although intravitreal injection targets the retina, the restricted number of injected cells still requires the precise biodistribution of MSCs near the injury site. Here, we found that retinal I/R led to BRB breakdown, which induced protein and cell leakage from the circulation. Retinal cell death and diminished visual function were subsequently detected. Moreover, the expression of the chemokine CCL5 increased after retinal I/R, and CCL5 colocalized with the BRB. We then overexpressed CCR5 in human induced pluripotent stem cell-derived MSCs (iMSCs). In vivo, intravitreal-injected iMSCCCR5 preferentially migrated and directly integrated into the BRB, which preferably restored BRB integrity and eventually promoted retinal function recovery after retinal I/R. In summary, our work suggested that iMSCs act as biopatches for BRB preservation and that iMSC-based therapy is a promising therapeutic approach for retinal diseases related to I/R.

Blood–retinal barrier

10.1016/j.omtn.2024.102445

Cite

Citations (0)