Prior corticosteroid therapy presents a major challenge in the diagnosis of CNS lymphomas, particularly in stereotactic biopsies. In this study we analysed the cytological, histopathological and immunohistochemical features in stereotactic biopsies of 25 primary CNS lymphoma cases pre-treated with corticosteroids. We documented the extent and the frequency of each finding. We also investigated the significance of subjectivity in evaluation of these biopsies in 3 seperate sessions including the final diagnostic decision. In 48% of our cases the diagnosis was straightforward. These cases were characterized by prominent blasts either in diffuse paranchymal infiltrates or in perivascular regions. The remaining 52% demonstrated some degree of variability among pathologists. Lymphoid atypia other than the typical blastic morphology appeared as a subjective finding and this was more pronounced in cytology preparations. In our study, corticosteroid pre-treatment in primary CNS lymphoma was associated with a large spectrum of histopathological, immunohistochemical and cytological findings. Combined use of an extended immunohistochemical panel would increase the possibility of conclusive diagnosis. Nevertheless some of these findings and therefore the diagnosis are open to subjectivity.
Sarcoidosis is a multisystemic granulomatous disease. In the case presented, autoamputation of the distal phalanx of a little finger of the left hand was observed. The possibility of autodigital amputation as a result of sarcoidosis is discussed.
Abstract Cutaneous metastasis of bladder carcinoma is extremely rare. Iatrogenic implantations have been the main cause in the majority of cases of transitional cell carcinoma with cutaneous metastasis. Otherwise, primary cutaneous metastasis is accepted as the late manifestation of systemic spread. The present paper describes a case of relatively early and extensive skin metastasis of transitional cell carcinoma in a 78‐year‐old man. The patient had a histopathological diagnosis of poorly differentiated (grade III) muscle invasive transitional cell carcinoma with a staging of T2NOMO 6 months prior to presenting. He presented to our outpatient clinic with a 3‐month history of skin lesions as multiple, rubbery subcutaneous nodules. Radiological reinvestigation revealed no other metastatic site (including bone and lung), except for a metastatic nodule in the liver. The present paper reports an interesting and rare case of extensive skin metastasis of transitional cell carcinoma as the primary complaint.
Macrodystrophia lipomatosa is a rare disorder characterized by three-dimensional enlargement of one or more fingers or toes with predominantly fibroadipose tissue. Radiographically, it appears as hypertrophy of soft tissues and bones. The pathologic findings are infiltration and hypertrophy of adipose tissue in subcutaneous tissue, nerve sheaths, and periosteum. Macrodystrophia lipomatosa is usually diagnosed during childhood. The case presented here involves the most elderly patient with the condition ever reported, to our knowledge. As such, it may advance current knowledge of macrodystrophia lipomatosa. Special emphasis is given to the unique “bridge” formation seen radiographically in this case. (J Am Podiatr Med Assoc 95(5): 486–490, 2005)
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Gönül M, Bilen G, Gökce A, Alper M. A case of papular elastorrhexis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2016;33(1):70-72. doi:10.5114/pdia.2016.57766. APA Gönül, M., Bilen, G., Gökce, A., & Alper, M. (2016). A case of papular elastorrhexis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 33(1), 70-72. https://doi.org/10.5114/pdia.2016.57766 Chicago Gönül, Müzeyyen, Göknur Bilen, Aysun Gökce, and Murat Alper. 2016. "A case of papular elastorrhexis". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 33 (1): 70-72. doi:10.5114/pdia.2016.57766. Harvard Gönül, M., Bilen, G., Gökce, A., and Alper, M. (2016). A case of papular elastorrhexis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 33(1), pp.70-72. https://doi.org/10.5114/pdia.2016.57766 MLA Gönül, Müzeyyen et al. "A case of papular elastorrhexis." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 33, no. 1, 2016, pp. 70-72. doi:10.5114/pdia.2016.57766. Vancouver Gönül M, Bilen G, Gökce A, Alper M. A case of papular elastorrhexis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2016;33(1):70-72. doi:10.5114/pdia.2016.57766.
Subepidermal calcified nodules are rarely seen and are classified under idiopathic subepidermal calcifications. They commonly affect children. It is most frequently encountered in the face, and it is less common in the extremities. Here, we present a case where the lesion was localized on the knees of a 23-year-old female patient.
