Lili Cai

Longhua Hospital Shanghai University of Traditional Chinese Medicine

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Lijun Jia

Nanjing University of Chinese Medicine

Yong‐Guang Jia

South China University of Technology

Lihui Li

Longhua Hospital Shanghai University of Traditional Chinese Medicine

Shiwen Wang

National Institute for Viral Disease Control and Prevention

Wenjuan Zhang

Fudan University Shanghai Cancer Center

Yupei Liang

Longhua Hospital Shanghai University of Traditional Chinese Medicine

Yongqun Xie

Fujian Agriculture and Forestry University

Yanyu Jiang

Karolinska Institutet

Hyungsuk Lim

University of Canterbury

Sa Liu

South China University of Technology

Cooperative Institutions

Chinese Academy of Sciences

Shanghai University of Traditional Chinese Medicine

Fudan University

University of Chinese Academy of Sciences

Longhua Hospital Shanghai University of Traditional Chinese Medicine

Shanghai Jiao Tong University

Zhejiang University

Chinese PLA General Hospital

Sun Yat-sen University

South China University of Technology

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Antisense Oligonucleotide against hTERT (Cantide) Inhibits Tumor Growth in an Orthotopic Primary Hepatic Lymphoma Mouse Model

PLoS ONE (2012)

Bo Yang Ruili Yu Shuai Tuo Chao-wei Tuo Qiu‐Zhen Liu

Background Human xenograft models, resulting from orthotopic transplantation (implantation into the anatomically correct site) of histologically intact tissue into animals, are important for investigating local tumor growth, vascular and lymphatic invasion at the primary tumor site and metastasis. Methodology/Principal Findings We used surgical orthotopic transplantation to establish a nude mouse model of primary hepatic lymphoma (PHL), HLBL-0102. We performed orthotopic transfer of the HLBL-0102 tumor for 42 generations and characterized the tumor cells. The maintenance of PHL characteristics were supported by immunohistochemical and cytogenetic analysis. We also report the antitumor effect of Cantide, an antisense phosphorothioate oligonucleotide against hTERT, on the growth of HLBL-0102 tumors. We showed a significant, dose-dependent inhibition of tumor weight and serum LDH activity in the orthotopically transplanted animals by Cantide. Importantly, survival was prolonged in Cantide-treated HLBL-0102 tumor-bearing mice when compared to mock-treated mice. Conclusions/Significance Our study provided the basis for the development of a clinical trial protocol to treat PHL.

Primary tumor

10.1371/journal.pone.0041467

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Citations (7)

Synthesis of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one from maltol and its taste identification

Food Chemistry (2021)

Zhifei Chen Gaolei Xi Yufeng Fu Qingfu Wang Lili Cai

Maltol

Pyran

Identification

Bitter Taste

10.1016/j.foodchem.2021.130052

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Citations (11)

β-Cyclodextrins as sustained-release carriers for natural wood preservatives

Industrial Crops and Products (2018)

Lili Cai Dragica Jeremic Hyungsuk Lim Yunsang Kim

Allyl isothiocyanate

White rot

Penetration (warfare)

10.1016/j.indcrop.2018.12.061

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Citations (30)

Ascorbate inducible N259 glycans on prolyl 4-hydroxylase subunit α1 promote hydroxylation and secretion of type I collagen

Cellular and Molecular Life Sciences (2019)

Run Shi Weimin Hu Yan Zhang Shanshan Gao Andrew H. Smith

Hydroxylation

Type I collagen

10.1007/s00018-019-03081-w

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Citations (15)

NEDD8-conjugating enzyme UBC12 as a novel therapeutic target in esophageal squamous cell carcinoma

Signal Transduction and Targeted Therapy (2020)

Shiwen Wang Jingrong Xian Lihui Li Yanyu Jiang Yue Liu

10.1038/s41392-020-00226-3

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Citations (17)

Proteome-wide Mapping of Endogenous SUMOylation Sites in Mouse Testis

Molecular & Cellular Proteomics (2017)

Lili Cai Jun Tu Lei Song Zhihua Gao Kai Li

SUMOylation is a reversible post-translational modification involved in various critical biological processes. To date, there is limited approach for endogenous wild-type SUMO-modified peptides enrichment and SUMOylation sites identification. In this study, we generated a high-affinity SUMO1 antibody to facilitate the enrichment of endogenous SUMO1-modified peptides from Trypsin/Lys-C protease digestion. Following secondary Glu-C protease digestion, we identified 53 high-confidence SUMO1-modified sites from mouse testis by using high-resolution mass spectrometry. Bioinformatics analyses showed that SUMO1-modified proteins were enriched in transcription regulation and DNA repair. Nab1 was validated to be an authentic SUMOylated protein and Lys479 was identified to be the major SUMOylation site. The SUMOylation of Nab1 enhanced its interaction with HDAC2 and maintained its inhibitory effect on EGR1 transcriptional activity. Therefore, we provided a novel approach to investigating endogenous SUMOylation sites in tissue samples.

Proteome

SUMO enzymes

10.1074/mcp.m116.062125

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Citations (19)

Effect of Danshen ligustrazine for injection on blood rheology,hs-CRP and fat metabolism on elderly patients with unstable angina pectoris

Shiyong yaowu yu linchuang (2014)

Lili Cai

Objective To observe the effect of Danshen ligustrazine for injection on blood rheology,high-sensitivity C-reactive protein( hs-CRP) and fat metabolism on elderly patients w ith unstable angina pectoris( UAP).Methods 106 elderly patients with UAP were randomly divided into treatment group( n = 54) and control group( n =52). Control group w as treated according to the UAP treatment guidelines,treatment group w as added w ith Danshen ligustrazine for injection 10 mL in 0. 9% sodium chloride 250 mL iv drip once a day,for 15 consecutive days on the basis of control group. The changes of hs-CRP,indexes of blood rheology and fat metabolism w ere measured before and after treatment. Results The improvements of angina and ECG in the treatment group w ere better than those in the control group( P 0. 05). After treatment,the hs-CRP in the tw o groups decreased than before treatment,and the treatment group decreased significantly than that of control group( P 0. 05). After treatment,the indexes of blood rheology and fat metabolism w ere significantly improved than before treatment( P 0. 05). There w as no obvious adverse reactions in the tw o groups after treatment. Conclusion Danshen ligustrazine for injection has a good curative effect on elderly patients w ith UAP,w hich might be related to reducing hs-CRP,improving blood rheology and fat metabolism.

Unstable angina

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Citations (1)

Study on the Application of SVM in Supplier Primary Election

Lili Cai Fugeng Shong Deling Yuan

Supplier selection is one of the most important things in supply chain management, the process of choosing a suitable supplier will effect enterprise’s production and quality directly. This article puts forward a two-stage model of supplier selection based on analysis the problem of supplier managem

Supplier relationship management

Supplier evaluation

10.4108/wkdd.2008.2636

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Citations (1)

An activity-based fluorescent probe and its application for differentiating alkaline phosphatase activity in different cell lines

Chemical Communications (2020)

Yong He Junli Yu Xiangzi Hu Shumei Huang Lili Cai

An activity-based fluorescent probe with the characteristics of AIE + ESIPT has been reported for differentiating the alkaline phosphatase activity in different cell lines.

10.1039/d0cc06129h

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Citations (26)

Molecular dynamics investigation of epoxy resin adsorption mechanisms on clay surfaces and the mechanical properties of epoxy resin-clay

Scientific Reports (2024)

Sijie Tao Dejian Shen Xin Wang Lili Cai Chunying Wu

The strength of natural clay can be improved with epoxy resins. However, nanoscale curing mechanisms remain poorly understood, which is essential for enhancing stability. In this study, molecular dynamics simulation was employed to calculate the quantity of interface hydrogen bonds, adsorption energy, radius of gyration, and mechanical properties of clay cured by diglycidyl ether of bisphenol-A epoxy resin (DGEBA), diglycidyl ether 4,4'-dihydroxy diphenyl sulfone (DGEDDS), and Aliphatic epoxidation of olefin resin (AEOR). Adsorption behavior and mechanical properties of the clay cured by three epoxy resins were investigated: (1) The chain structure of AEOR led to 18.2% more hydrogen bonds than DGEBA and 59.1% more than DGEDDS. (2) The simulated adsorption energies for DGEBA, DGEDDS, and AEOR with kaolinite were 92.59, 98.25, and 116.87 kcal·mol−1, respectively. (3) The bulk and shear modulus of kaolinite increased by 4.93% and 4.80% when using AEOR. The interface stability and mechanical properties of kaolinite were also improved through strong hydrogen bonds and high adsorption energy. (4) The improvement in Young's modulus of kaolinite was most significant with AEOR, followed by DGEDDS. AEOR excelled in the Z direction, while DGEDDS excelled in the X and Y directions. This research provided a theoretical foundation to effectively improve the properties of clay using epoxy resins.

10.1038/s41598-024-76950-5

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Citations (0)