R. Parkash

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John L. Sapp

Queen Elizabeth II Health Sciences Centre

Vidal Essebag

McGill University Health Centre

Steve Doucette

Dalhousie University

R. Glenn Wells

University of Ottawa

L. Blier

Institut Universitaire de Cardiologie et de Pneumologie de Québec

Martin J. Gardner

Vanderbilt University Medical Center

Ahmed El‐Damaty

University Hospital Heidelberg

Chris Gray

Manchester University NHS Foundation Trust

WG Stevenson

Vanderbilt University Medical Center

Isabelle Nault

Université Laval

Cooperative Institutions

Charles University

Inserm

Istituti di Ricovero e Cura a Carattere Scientifico

Scunthorpe General Hospital

National and Kapodistrian University of Athens

Leiden University Medical Center

Institute of Cardiology

Maastricht University

Medical University of Silesia

Harvard University

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ABSTRACTS

EP Europace (2009)

Amir AbdelWahab Martin J. Gardner R. Parkash Magdy N. Basta Jeff Sapp

10.1093/europace/eup171

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Citations (1)

VALIDATION OF PACED P-WAVE MORPHOLOGY TEMPLATES TO GUIDE ATRIAL TACHYCARDIA LOCALIZATION

Canadian Journal of Cardiology (2017)

Amir AbdelWahab Dhaifallah Yahya John L. Sapp Hussien Rizk R. Parkash

BACKGROUND: Surface ECG is a useful tool to guide mapping of focal atrial tachycardia (AT).We have previously proposed an algorithm based on paced P wave morphology templates by pacing from different anatomical sites in both atria.OBJECTIVE: Validation of this algorithm in a retrospective series of AT patients who underwent catheter ablation.METHODS: We prospectively enrolled consecutive patients who underwent electrophysiology study, had no heart disease and no atrial enlargement.Atrial pacing, at twice diastolic threshold, was carried out at different anatomical sites in both atria.Paced P wave morphology and duration were assessed.An algorithm was generated from the constructed templates of each pacing site.The algorithm was applied on a retrospective series of successfully ablated AT patients between 2006 and 2016.Overall and site-specific accuracy were determined.RESULTS: Derivation cohort included 65 patients (25 men, age 37AE13 years).Atrial pacing was performed in 1025 sites in 61 patients (95%) in the right atrium and in 15 patients (23%) in the left atrium.The validation cohort included 71 patients (28 men, age 52AE19 years).AT were right atrial in 66.2%.The algorithm successfully predicted AT origin in 91.5% of patients (100% in LA and 87.2% in RA).It was off by 1 adjacent segment in the remaining 8.5%.Site-specific accuracies are shown in Table1.CONCLUSION: A simple ECG algorithm based on paced P-wave morphology templates was highly accurate in localizing sites of origin of focal atrial tachycardia particularly those of LA origin.

Atrial tachycardia

Template

P wave

Morphology

10.1016/j.cjca.2017.07.288

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INFLUENCE OF AGE AND SEX ON VENTRICULAR ARRHYTHMIA IN AN ICD POPULATION

Canadian Journal of Cardiology (2014)

Kimberly Styles Ciorsti MacIntyre John L. Sapp M. Gardner Chris Gray

Medical record

10.1016/j.cjca.2014.07.463

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COST EFFECTIVENESS OF VENTRICULAR TACHYCARDIA ABLATION VERSUS ESCALATION OF ANTIARRHYTHMIC DRUG THERAPY IN THE VANISH TRIAL

Canadian Journal of Cardiology (2017)

John L. Sapp K Coyle R. Parkash J. Healey Chris Gray

Pharmacotherapy

10.1016/j.cjca.2017.07.052

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AUTOMATED LOCALIZATION OF LEFT VENTRICULAR PACING SITES FROM THE 12-LEAD ELECTROCARDIOGRAM DURING CATHETER ABLATION STUDY

Canadian Journal of Cardiology (2014)

Jonathan Toma John L. Sapp Ahmed El‐Damaty JW Warren Paul J. MacInnis

Lead (geology)

Ventricular pacing

Cardiac Ablation

10.1016/j.cjca.2014.07.462

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EFFECT OF BASELINE ANTIARRHYTHMIC DRUG ON OUTCOMES WITH ABLATION IN ISCHEMIC VENTRICULAR TACHYCARDIA: A VANISH SUBSTUDY

Canadian Journal of Cardiology (2017)

R. Parkash Isabelle Nault Léna Rivard L.J. Gula Vidal Essebag

ventricular irritability (VI, a non-sustained arrhythmic response < 1 sec).A single dose of ibrutinib increased AF inducibility (4/10 vs. 0/10, P < 0.05, duration 36.6 +/-56.5 sec) and VI (5/10 vs. 0/10, P < 0.05).There was no difference after chronic dosing for both AF (2/8 vs. 2/8, P¼1) and VI (2/8 vs. 1/8, P¼0.52).We demonstrated that ibrutinib acutely increased atrial and non-sustained ventricular arrhythmia susceptibility in the mouse.Our results suggest that chronic exposure with washout does not promote persistent electrical remodelling.Together this suggests that arrhythmia inducibility is a transient, potentially off-target, drug effect.

Baseline (sea)

10.1016/j.cjca.2017.07.136

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