William J. Wechter

Encore Pharmaceuticals (United States)

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Co-Authors

Euan Murray

University of Edinburgh

Darko Kantoci

ET Enterprises (United Kingdom)

David D. Quiggle

Encore Pharmaceuticals (United States)

Duane T. Gish

W.E. Upjohn Institute for Employment Research

G L Neil

Johnson & Johnson (United States)

Elaine J. Benaksas

Encore Pharmaceuticals (United States)

Annette E. Bigornia

Loma Linda University

Herbert G. Johnson

W.E. Upjohn Institute for Employment Research

C. M. Hall

Natural Resources Conservation Service

Douglas D. Leipold

University of California, San Francisco

Cooperative Institutions

W.E. Upjohn Institute for Employment Research

Loma Linda University

Harvard University

National Institutes of Health

Loma Linda University Medical Center

University of Michigan–Ann Arbor

National Institute on Aging

Hebrew University of Jerusalem

University of California, San Francisco

Oklahoma Medical Research Foundation

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Nucleic acids. 14. Synthesis and antiviral activity of some 5'-esters of 9-.beta.-D-arabinofuranosyladenine (ara-A)

Journal of Medicinal Chemistry (1973)

Harold E. Renis Duant T. Gish B. A. COURT Emerson E. Eidson William J. Wechter

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNucleic acids. 14. Synthesis and antiviral activity of some 5'-esters of 9-.beta.-D-arabinofuranosyladenine (ara-A)Harold E. Renis, Duant T. Gish, Barbara A. Court, Emerson E. Eidson, and William J. WechterCite this: J. Med. Chem. 1973, 16, 7, 754–757Publication Date (Print):July 1, 1973Publication History Published online1 May 2002Published inissue 1 July 1973https://pubs.acs.org/doi/10.1021/jm00265a003https://doi.org/10.1021/jm00265a003research-articleACS PublicationsRequest reuse permissionsArticle Views52Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

BETA (programming language)

10.1021/jm00265a003

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Citations (12)

The effects of NSAIDs and E-prostaglandins on bone: A two signal hypothesis for the maintenance of skeletal bone

Birkhäuser Basel eBooks (1992)

William J. Wechter

Since the formulation of the Raisz hypothesis asserting that prostaglandin-E (PGE) was responsible for bone resorption [1], arachidonic acid metabolites, particularly PGE2 have been the focus of a great number of experimental bone studies. Primarily carried out in vitro, these studies showed that particular cyclooxygenase products are the mediators of osteoclast activity and consequently bone resorption. Considerable data, especially whole animal studies, dispute this widely held hypothesis.

10.1007/978-3-0348-7144-0_10

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Citations (12)

Endogenous natriuretic factors 3: isolation and characterization of human natriuretic factors llu-α, LLU-β1, and llu-γ

Life Sciences (1995)

Euan Murray Darko Kantoci Sally A. Dewind Annette E. Bigornia Derin C. D’Amico

Ultrafiltration (renal)

10.1016/0024-3205(95)02207-y

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Citations (19)

ChemInform Abstract: NUCLEINSAEUREN 6. MITT. MECHANISMUS DER DESAMINIERUNG VON CYTIDIN

Chemischer Informationsdienst Organische Chemie (1970)

William J. Wechter Robert C. Kelly

Abstract Der Verlauf der Hydrolyse von Cytidin zu Uridin in Deuteriumoxid bei verschiedenen pD‐Werten zwischen 4,7 und 8,2 und bei 95% wird NMR‐spektroskopisch verfolgt.

10.1002/chin.197038172

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Citations (0)

Subject Index

Nephron Experimental Nephrology (1998)

Ian Zachary Nigel J. Brunskill Manuela Ghielli Walter Verstrepen Etienne J. Nouwen

proteins 148 Computed tomography 382 Conditional transgene expression 438 Confocal laser scanning microscope 398

10.1159/000020576

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Gradation of specificity with regard to sugar among nucleases

Biochemical and Biophysical Research Communications (1968)

William J. Wechter Andrzej Mikulski M. Laskowski

Nuclease

Deoxyribose

Mung bean

Distilled water

10.1016/0006-291x(68)90453-1

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Citations (8)

Additions and Corrections - ara-Cytidine Acylates. Use of Drug Design Predictors in Structure-Activity Relationship Correlation.

Journal of Medicinal Chemistry (1976)

William J. Wechter Michael F. Johnson C. M. Hall Douglas Warner Ardin Berger

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditions and Corrections - ara-Cytidine Acylates. Use of Drug Design Predictors in Structure-Activity Relationship Correlation.W. Wechter, M. Johnson, C. Hall , D. Warner, A. Berger, A. Wenzel, D. Gish, and G. NeilCite this: J. Med. Chem. 1976, 19, 12, 1425Publication Date (Print):December 1, 1976Publication History Published online13 September 2004Published inissue 1 December 1976https://pubs.acs.org/doi/10.1021/jm00234a601https://doi.org/10.1021/jm00234a601research-articleACS PublicationsRequest reuse permissionsArticle Views21Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Cytidine

Structure–activity relationship

10.1021/jm00234a601

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A biomechanical evaluation of RS-Ketoprofen and PGE/sub 2/ treatment in reducing bone loss in ovariectomized rats

Subrata Saha LaKessha Bridges William J. Wechter

Osteoporosis is the most common bone disorder in the USA. The authors evaluated the effectiveness of two experimental drugs, an arylpropionic acid (RS-Ketoprofen) and prostoglandin E/sub 2/ (PGE/sub 2/) in reducing the bone loss due to osteoporosis. Results of mechanical testing of long bones of ovariectomized rats of control groups and those treated with these drugs showed that a combination of these two drugs could be effective in reducing bone loss due to estrogen deficiency and maintain the mechanical integrity of the skeletal system.< >

Ketoprofen

10.1109/sbec.1993.247424

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Calculation of Inversion Half‐Lives of Aryl Propionic Acid Class Nonsteroidal Antiinflammatory Drugs

The Journal of Clinical Pharmacology (1996)

Darko Kantoci William J. Wechter

Although inversion of the R‐ enantiomers of the aryl propionic acid (APA) class of nonsteroidal antiinflammatory drugs (NSAIDs) in humans and other mammals has been known for more than 20 years, no satisfactory method has been developed for evaluating the half‐life of the inversion process. This parameter is useful in assessing the pharmacodynamic contribution of the R‐ prodrug to the cyclooxygenase‐inhihiting S‐ enantiomers. Further, it provides a similar means of evaluating the analgesic contribution of R‐ enantiomers to racemic mixtures. Using human and animal data, we have mathematically determined the inversion half‐life (t 1/2i ) for ibuprofen, ketoprofen, and fenoprofen. The relation of the sensitivity of this value to the terminal half‐life (t 1/2 ) of the R‐ enantiomers of APA class drugs also is discussed .

Ketoprofen

Ibuprofen

10.1002/j.1552-4604.1996.tb05039.x

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Citations (7)

Chiral pharmacokinetics of rac‐flurbiprofen and pharmacodynamics of anabolic bone response in the normal rat

Chirality (1994)

William J. Wechter Annette E. Bigornia Euan Murray W.S.S. Jee

Abstract The route of administration of the NSAID, flurbiprofen (sq vs. po) resulted in positive and negative results respectively with regard to enhanced cancellous and cortical bone accumulation in the immature rat. This pharmacokinetic study was an effort to understand the pharmacodynamic difference between the two routes of administration observed when the same dose range of drug, given as single daily doses, had been employed in both studies. Conventional chiral pharmacokinetics were evaluated in young rats. A significant difference was observed in the T max of the active (S)‐enantiomer by both administration routes (sq 4 h and po 1 h). The bioavailability, as evaluated by AUCs favored the sq route as expected. The plasma concentrations over 18 h, at steady state, for one po dose group (0.5 mg/kg/day) fell well within the therapeutic window described by the 0.1 and 0.5 mg/kg sq doses which had demonstrated anabolic bone activity. Oral dosing had exhibited no significant bone activity. We conclude that the pharmacodynamic difference between routes of administration cannot be simply explained on a pahrmacokinetic basis. Consequently, experiments detailing the pharmacodynamics and pharmacokinetics of single and multiple dose administration of aryl‐propionic acids in normal and osteopenic states need further pharmacologic study. © 1994 Wiley‐Liss, Inc.

Pharmacodynamics

Flurbiprofen

10.1002/chir.530060602

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Citations (7)