Hossein Pournajafi‐Nazarloo

Indiana University Bloomington

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Leah H. Rubin

Johns Hopkins University

C. Sue Carter

Indiana University Bloomington

C. Sue Carter

Indiana University Bloomington

Kozo Hashimoto

Kōchi University

Lauren L. Drogos

University of Calgary

John A. Sweeney

West China Hospital of Sichuan University

James L. Reilly

Northwestern University

Jeffrey R. Bishop

University of Minnesota

John M. Davis

University of Illinois Chicago

William M. Kenkel

University of Delaware

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University of Illinois Chicago

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Massachusetts General Hospital

Indiana University Bloomington

University of Florida

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Johns Hopkins University

University of Pittsburgh

University of Maryland, College Park

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In Search of an Adult Attachment Stress Provocation to Measure Effect on the Oxytocin System: A Pilot Validation Study

Carolina Digital Repository (University of North Carolina at Chapel Hill) (2013)

Michelle L. Munro‐Kramer Stephanie L. Brown Hossein Pournajafi‐Nazarloo C. Sue Carter William D. Lopez

10.17615/cwk1-qc32

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Citations (1)

Changes in social functioning and circulating oxytocin and vasopressin following the migration to a new country

Physiology & Behavior (2014)

Jean-Philippe Gouin Hossein Pournajafi‐Nazarloo C. Sue Carter

Social functioning

10.1016/j.physbeh.2014.11.021

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Citations (8)

Marital behavior, oxytocin, and wound healing

Brain Behavior and Immunity (2010)

Jean‐Philippe Gouin S. Carter Hossein Pournajafi‐Nazarloo Ronald Glaser W B Malarkey

Stroke

Preparedness

Family Caregivers

10.1016/j.bbi.2010.07.026

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Citations (12)

Stress differentially modulates mRNA expression for corticotrophin-releasing hormone receptors in hypothalamus, hippocampus and pituitary of prairie voles

Neuropeptides (2009)

Hossein Pournajafi‐Nazarloo Leila Partoo Lisa Sanzenbacher Jamespaul Paredes Kozo Hashimoto

Corticotropin-releasing hormone

10.1016/j.npep.2008.12.002

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Citations (25)

Oxytocin in Pregnancy and the Postpartum: Relations to Labor and Its Management

Frontiers in Public Health (2014)

Marie Prévost Phyllis Zelkowitz Togas Tulandi Barbara Hayton Nancy Feeley

The purpose of this study was to examine variations in endogenous oxytocin levels in pregnancy and postpartum state. We also explored the associations between delivery variables and oxytocin levels. A final sample of 272 mothers in their first trimester of pregnancy was included for the study. Blood samples were drawn during the first trimester and third trimester of pregnancy and at 8 weeks postpartum. Socio-demographic data were collected at each time point and medical files were consulted for delivery details. In most women, levels of circulating oxytocin increased from the first to third trimester of pregnancy followed by a decrease in the postpartum period. Oxytocin levels varied considerably between individuals, ranging from 50 pg/mL to over 2000 pg/mL. Parity was the main predictor of oxytocin levels in the third trimester of pregnancy and of oxytocin level changes from the first to the third trimester of pregnancy. Oxytocin levels in the third trimester of pregnancy predicted a self-reported negative labor experience and increased the chances of having an epidural. Intrapartum exogenous oxytocin was positively associated with levels of oxytocin during the postpartum period. Our exploratory results suggest that circulating oxytocin levels during the third trimester of pregnancy may predict the type of labor a woman will experience. More importantly, the quantity of intrapartum exogenous oxytocin administered during labor predicted plasma oxytocin levels 2 months postpartum, suggesting a possible long-term effect of this routine intervention, the consequences of which are largely unknown.

10.3389/fpubh.2014.00001

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Citations (210)

Oxytocin selectively increases ERα mRNA in the neonatal hypothalamus and hippocampus of female prairie voles

Neuropeptides (2006)

Hossein Pournajafi‐Nazarloo Michael S. Carr Eros Papademeteriou Jennifer V. Schmidt Bruce S. Cushing

Prairie vole

10.1016/j.npep.2006.10.002

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Citations (23)

The link between oxytocin plasma levels and observed communication behaviors during sexual and nonsexual couple discussions: An exploratory study

Psychoneuroendocrinology (2021)

Rick Roels Uzma S. Rehman C. Sue Carter Hossein Pournajafi‐Nazarloo Erick Janssen

Association (psychology)

Oxytocin receptor

10.1016/j.psyneuen.2021.105265

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Citations (10)

The Role of Endogenous Oxytocin in Anxiolysis: Structural and Functional Correlates

Biological Psychiatry Cognitive Neuroscience and Neuroimaging (2017)

Katie Lancaster Lauren Goldbeck Hossein Pournajafi‐Nazarloo Jessica J. Connelly C. Sue Carter

10.1016/j.bpsc.2017.10.003

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Citations (23)

The Complex Role of Oxytocin in Major Depressive Disorder

Clinical and Experimental Health Sciences (2022)

A. Halaris Jasleen K. Singh C. Sue Carter Hossein Pournajafi‐Nazarloo Brandon Hage

Objective: One proposed mechanism to subclassify depressive illness relates oxytocinergic dysregulation, via its effect on social behavior and Hypothalamic-pituitary-adrenal (HPA) axis inhibition. To further investigate the role of oxytocin in Major Depressive Disorder (MDD), we compared plasma oxytocin levels in patients with MDD to healthy controls. Methods: Plasma samples from 12 healthy controls and 33 MDD patients were collected at baseline, 8 weeks, and 12 weeks of treatment and oxytocin was measured by enzyme-immunoassay. Depression and anxiety scales were administered at screening, baseline, and at weeks 2, 4, 8, and 12 of treatment. Additionally, we investigated possible associations between blood concentrations of inflammatory biomarkers and oxytocin. Results: The average baseline oxytocin level was 429 pg/ml in MDD patients and 392 pg/ml in healthy control subjects. A significant negative correlation was found between baseline oxytocin and BMI. Treatment responders had significantly lower baseline oxytocin levels than non-responders. After stratifying patients into low and high oxytocin groups based on a median split, within the high oxytocin group, patients with no prior depressive episodes had significantly higher baseline oxytocin levels. A Chi-square distribution test revealed that African American patients were more likely to belong to the high baseline oxytocin group while Caucasian and Hispanic patients were more likely to belong to the low baseline oxytocin group. We found significant correlations between oxytocin and Von-Willebrand Factor (VWF) and Epidermal Growth Factor (EGF), only within the high oxytocin subgroup. There were no other significant correlations between baseline oxytocin and any other biomarkers. Conclusion: Within our limited patient cohort, our data adds to the mixed literature regarding the role of oxytocin in MDD. Oxytocinergic dysregulation and confounding factors may play a role for a subset of depressed patients.

Oxytocin receptor

10.33808/clinexphealthsci.975706

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Citations (1)

Effects of sex, menstrual cycle phase, and endogenous hormones on cognition in schizophrenia

Carolina Digital Repository (University of North Carolina at Chapel Hill) (2015)

Leah H. Rubin C. Sue Carter Lauren L. Drogos Hossein Pournajafi‐Nazarloo John A. Sweeney

10.17615/wxkj-y309

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Citations (0)