Jacquelyn Gervay

University of Arizona

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Samuel J. Danishefsky

Kettering University

Takeshi Oriyama

Ibaraki University

David A. Griffith

Pfizer (United States)

Michael E. Jung

UCLA Health

Terrence M. Flaherty

University of California, San Francisco

Frank E. McDonald

Emory University

Koshi Koseki

Japan Tobacco (Japan)

John M. Peterson

Sterling Research Group

Abby L. Parrill

University of Memphis

Michael J. Hadd

ET International (United States)

Cooperative Institutions

University of Arizona

Yale University

Hungarian Academy of Sciences

Kettering University

University of Debrecen

Scripps Research Institute

University of California, Berkeley

The University of Tokyo

University of California, Davis

Centro de Investigaciones Biológicas Margarita Salas

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Three-Spin Effects in 1H-{13C} (Reverse) Heteronuclear NOE and INEPT-(R)HOESY Spectra of [1-13C]Me α,β-D-Glucopyranoside

Journal of Magnetic Resonance Series B (1994)

Gyula Batta Katalin E. Kövér Jacquelyn Gervay

Heteronuclear molecule

Glycosidic bond

Oligosaccharide

10.1006/jmrb.1994.1028

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Citations (2)

ChemInform Abstract: A Stereospecific Route to 2-Deoxy-β-glycosides.

ChemInform (1992)

Jacquelyn Gervay Samuel J. Danishefsky

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Stereospecificity

10.1002/chin.199211241

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ChemInform Abstract: Application of Glycals to the Synthesis of Oligosaccharides: Convergent Total Syntheses of the Lewis X Trisaccharide Sialyl Lewis X Antigenic Determinant and Higher Congeners.

ChemInform (1995)

Samuel J. Danishefsky Jacquelyn Gervay John Peterson Frank E. McDonald Koshi Koseki

Trisaccharide

Sialyl-Lewis X

10.1002/chin.199529277

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[1- 13 C]Meα,β-D-グルコピラノシドの 1 H-{ 13 C}(逆)異種核NOEおよびINEPT-(R)HOESYスペクトルにおける3スピン効果

Journal of Magnetic Resonance Series B (1994)

Gyula Batta K. E. KOEVER Jacquelyn Gervay

Source

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HI/acetic acid reduction of peracetylated N-acetyl neuraminic acid esters to stereoselectively provide α-2-deoxy-2-hydrido derivatives

Tetrahedron Letters (1997)

Jacquelyn Gervay Travis Q. Gregar

Neuraminic acid

Hydrogen iodide

10.1016/s0040-4039(97)01323-3

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Citations (12)

1 Sialyl-Lewis X (SLex)およびその類縁体の合成研究(口頭発表の部)

天然有機化合物討論会講演要旨集 (1992)

幸史古関 David A. Griffith Jacquelyn Gervay John M. Peterson Frank E. McDonald

Sialyl-Lewis X

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Utilization of ELISA Technology to Measure Biological Activities of Carbohydrates Relevant in Disease States

Current Medicinal Chemistry (1999)

Jacquelyn Gervay Katherine D. McReynolds

Abstract: Since its discovery in 1960, ELISA technology has been utilized in an increasing number of biological and biochemical investigations. It has proven to be one of the most powerful tools available for probing recognition processes involving protein/protein, protein/glycoprotein, protein/glycolipid and glycoprotein/glycolipid interactions. This review begins with an introduc tion that provides an historical perspective on the development of ELISA followed by a description of the different classifications of this assay. One of the fundamental elements of ELISA is the adhesion of a molecule of interest to a solid support, generally a microtiter plate. Recent developments in the area of adhesion and adsorption are also presented. Although ELISA has been used most extensively in studying protein/protein interactions, in the past 10 years there have been a number of advances in ELISA technology that have allowed recognition processes involving carbohydrates to be studied. This review focuses on the use of ELISA in investigating diseases where carbohydrate recognition processes are implicated. Since studies related to the HIV virus have provided a major impetus for the advancement of ELISA technology, this area of research is highlighted.

10.2174/0929867306666220207212948

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Citations (21)

Solution Phase Synthesis of Amide-Linked N-Acetyl Neuraminic Acid, α-Amino Acid, and Sugar Amino Acid Conjugates¹

The Journal of Organic Chemistry (1997)

P Ramamoorthy Jacquelyn Gervay

Peracetylated N-acetylneuraminic acid (NeuAc) was efficiently coupled to esters of glycine, alanine, and serine using BOP and HOBT in the presence of DIEA. Deprotection of the esters readied the NeuAc-α-amino acid conjugates for further elaboration. Coupling of the NeuAc-gly adduct with β-O-methoxy neuraminic acid methyl ester afforded a selectively protected glycine linked sialic acid dimer. 2-Amino-3,4-di-O-benzyl-(1→6)-anhydroglucose and alanine benzyl ester were also efficiently coupled to the bis adduct giving novel trimeric analogs. Elimination of the anomeric acetate from the NeuAc-gly dimer followed by global deprotection provided a novel saccharopeptide with modest clostridial sialidase inhibitory activity.

Neuraminic acid

Amide

Alanine

N-Acetylneuraminic acid

Sialidase

10.1021/jo9711246

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Citations (29)

ChemInform Abstract: Azaglycosylation of Complex Stannyl Alkoxides with Glycal-Derived Iodo Sulfonamides: A Straightforward Synthesis of Sialyl-Lewis X Antigen and Other Oligosaccharide Domains.

ChemInform (1993)

Samuel J. Danishefsky Koshi Koseki David A. Griffith Jacquelyn Gervay John Peterson

Glycal