Evangelia Dounousi

University of Ioannina

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Vassilios Liakopoulos

Aristotle University of Thessaloniki

ΑD

Αnila Duni

University Hospital of Ioannina

Theodoros Eleftheriadis

University of Thessaly

ΑP

Αikaterini Papagianni

Aristotle University of Thessaloniki

Stefanos Roumeliotis

AHEPA University Hospital

Carmine Zoccali

Renal Research Institute

Kostas C. Siamopoulos

University Hospital of Ioannina

ΛΛ

Λάμπρος Λάκκας

University of Ioannina

KΚ

Katerina Κ. Naka

University Hospital of Ioannina

Vasileios Koutlas

University Hospital of Ioannina

Cooperative Institutions

University of Ioannina

206

University Hospital of Ioannina

146

National and Kapodistrian University of Athens

114

Aristotle University of Thessaloniki

AHEPA University Hospital

Pediatric Nephrology of Alabama

University of Oxford

Inserm

Laiko General Hospital of Athens

University General Hospital Attikon

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FP376THE BURDEN OF CKD IN HIGH RISK CONDITIONS IN THE AFRICAN CONTINENT: A SYSTEMATIC REVIEW

Nephrology Dialysis Transplantation (2015)

Samar Abd ElHafeez Graziella D’Arrigo Davide Bolignano Evangelia Dounousi Giovanni Tripepi

10.1093/ndt/gfv175.58

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The Effect of Convective Dialytic Modalities on Arterial Stiffness in End-Stage Renal Disease Patients

InTech eBooks (2016)

Panagiotis I. Georgianos Evangelia Dounousi Theodoros Eleftheriadis Vassilios Liakopoulos

Among end-stage renal disease (ESRD) patients receiving hemodialysis, increased arterial stiffness is an independent cardiovascular risk predictor. Over the past few years, arterial stiffness attenuation has been increasingly recognized as a novel therapeutic target toward cardiovascular risk reduction in the dialysis population. Structural alterations related to the long-term arteriosclerotic process are difficult to modify; with the exception of blood pressure (BP)-lowering, there are no other therapeutic interventions with well-documented benefits in delaying the progression of arteriosclerosis among dialysis patients. Enhanced clearance of middle-to-high molecular weight solutes by combining convective and diffusive transport through hemodiafiltration and the associated benefits on microvascular endothelial function have generated the hypothesis that convective dialytic modalities may be advantageous in improving large-artery stiffness. This notion is supported by some clinical studies showing that switching ESRD patients from low-flux hemodialysis to high-efficiency on-line hemodiafiltration was associated with significant reduction in arterial stiffness. These beneficial effects, however, were not confirmed in a recent subanalysis of the CONvective TRAnsport STudy (CONTRAST) trial. In this chapter, we summarize the currently available evidence on the effect of hemodiafiltration versus hemodialysis on arterial stiffness, discussing also the potential clinical implications of this effect.

10.5772/63369

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Citations (1)

Incretin based therapies and SGLT-2 inhibitors in kidney transplant recipients with diabetes: A systematic review and meta-analysis

Diabetes Research and Clinical Practice (2020)

Dora Oikonomaki Evangelia Dounousi Anila Duni Stefanos Roumeliotis Vassilios Liakopoulos

Incretin

Lixisenatide

10.1016/j.diabres.2020.108604

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Hypertension in Chronic Kidney Disease: Novel Insights

Current Hypertension Reviews (2019)

Αnila Duni Evangelia Dounousi Paraskevi Pavlakou Theodoros Eleftheriadis Vassilios Liakopoulos

Management of arterial hypertension in patients with chronic kidney disease (CKD) remains a major challenge due to its high prevalence and associations with cardiovascular disease (CVD) and CKD progression. Several clinical trials and meta-analyses have demonstrated that aggressive treatment of hypertension in patients with and without CKD lowers the risk of CVD and all-cause mortality, nevertheless the effects of blood pressure (BP) lowering in terms of renal protection or harm remain controversial. Both home and ambulatory BP estimation have shown that patients with CKD display abnormal BP patterns outside of the office and further investigation is required, so as to compare the association of ambulatory versus office BP measurements with hard outcomes and adjust treatment strategies accordingly. Although renin-angiotensin system blockade appears to be beneficial in patients with advanced CKD, especially in the setting of proteinuria, discontinuation of renin-angiotensin system inhibition should be considered in the setting of frequent episodes of acute kidney injury or hypotension while awaiting the results of ongoing trials. In light of the new evidence in favor of renal denervation in arterial hypertension, the indications and benefits of its application in individuals with CKD need to be clarified by future studies. Moreover, the clinical utility of the novel players in the pathophysiology of arterial hypertension and CKD, such as microRNAs and the gut microbiota, either as markers of disease or as therapeutic targets, remains a subject of intensive research.

Discontinuation

10.2174/1573402115666190415153554

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Clinical Presentation and Outcomes of SARS-CoV-2 Infection in Patients with Pauci-Immune Glomerulonephritis

Journal of the American Society of Nephrology (2024)

Angeliki Sardeli Evangelia Dounousi Dimitra Gkalitsiou Konstantia Kantartzi Vassilios Liakopoulos

Rapidly progressive glomerulonephritis

Presentation (obstetrics)

2019-20 coronavirus outbreak

10.1681/asn.2024r2ensw1f

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Myocardial strain indices and coronary flow reserve are only mildly affected in healthy hypertensive patients

European Heart Journal (2022)

D Evangelou Aris Bechlioulis G Tzeltzes Λάμπρος Λάκκας Ioanna Theodorou

Abstract Hypertension is a major risk factor for cardiovascular disease and is associated with functional and structural changes in the heart and the vessels. Left ventricular deformation imaging with 2D Strain Echocardiography (2DSTE) and stress echocardiography with a vasodilator,such as dipyridamole (DIPSE), are useful tools for the detection of early myocardial abnormalities in hypertensive patients The aim of the current study was to investigate whether early (relatively healthy) hypertensive patients with normal left ventricular (LV) ejection fraction may differ in 2D Strain indices at baseline and in response to a stress test such as dipyridamole, compared to healthy controls. In the current study, the associations of 2DSTE indices and their changes following DIPSE with other studied parameters were also assessed. Forty-seven male hypertensive patients (aged 57±9 years) with normal ejection fraction and without left ventricular hypertrophy and 20 healthy male subjects were studied with conventional and 2D Strain echocardiography at rest and post DIPSE. Coronary flow reserve (CFR) in the left anterior descending artery following DIPSE was also evaluated. Global longitudinal strain (GLS) and TWIST were higher while UNTWIST rate was lower in hypertensives versus controls (p<0.05 for all). TWIST remained higher in hypertensives (p=0.021) after adjustment for differences in age and body mass index (BMI) between the groups. CFR was higher in controls compared to hypertensives even after adjustment for confounders (4.14 vs. 2.53, p=0.001). DIPSE-induced changes did not differ between the groups after adjustment for age and BMI (p>0.05 for all). DIPSE-induced improvement in GLS was associated with higher CFR only in hypertensive patients (r −0.372, p=0.010). The current study showed that well controlled hypertensive patients have mild echocardiographic differences compared to controls. Some of these differences appear to depend on age and Body mass index. A “hyper-rotation” phenomenon (higher TWIST) early in hypertension may be a compensatory mechanism to preserve global systolic LV function. Coronary microcirculatory function was impaired in hypertensive patients, albeit within normal range, and was associated with DIPSE-induced changes in myocardial long-axis systolic function. Funding Acknowledgement Type of funding sources: None.

Dipyridamole

Coronary flow reserve

Coronary vasodilator

10.1093/eurheartj/ehac544.031

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Coronary microcirculation and left ventricular diastolic function but not myocardial deformation indices are impaired early in patients with chronic kidney disease

Authorea (Authorea) (2022)

Aris Bechlioulis Λάμπρος Λάκκας Katerina Κ. Naka Annila Duni Chariklia Gouva

Aim . To investigate abnormalities in myocardial strain and classic echocardiographic indices and coronary flow reserve (CFR), in younger vs older CKD patients. Methods . Sixty consecutive CKD patients (<60 years old n=30, ≥60 years old n=30) and 30 healthy controls (age- and gender-matched with younger CKD patients) were recruited. An echocardiographic assessment including myocardial strain indices was performed at baseline and following dipyridamole administration in all participants. Results . Younger CKD patients had higher E/e’, left ventricular mass index and relative wall thickness and lower E’ (p<0.005 for all) compared to healthy controls. Older CKD patients had lower E/A and E’ (p<0.05 for both) compared to younger CKD patients; these differences did not remain significant after adjustment for age. CFR was higher in healthy controls compared to younger and older CKD patients (p<0.05 for both) without a significant difference between CKD groups. Dipyridamole-induced changes did not differ significantly among the 3 groups. Conclusions . Compared to healthy controls, impaired coronary microcirculation and left ventricular diastolic function, but not myocardial strain abnormalities, are found in young CKD patients and deteriorate with aging.

Dipyridamole

Coronary flow reserve

10.22541/au.167234583.32917684/v1

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Methodology used in studies reporting chronic kidney disease prevalence: a systematic literature review

Nephrology Dialysis Transplantation (2015)

Katharina Brück Kitty J. Jager Evangelia Dounousi Alexander Kainz Dorothea Nitsch

BackgroundMany publications report the prevalence of chronic kidney disease (CKD) in the general population. Comparisons across studies are hampered as CKD prevalence estimations are influenced by study population characteristics and laboratory methods.

10.1093/ndt/gfv131

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Citations (83)

Editorial: Molecular Mechanisms in Chronic Kidney Disease

Frontiers in Cell and Developmental Biology (2021)

Claudia Torino Evangelia Dounousi Samar Abd ElHafeez Nejra Prohić

NLRP3 inflammasome activation. Another mechanism involved in kidney fibrosis is the epithelialmesenchymal transition (EMT) Patients with CKD have an almost uniquely high risk of death and cardiovascular disease, and with a rate of incident cardiovascular events strongly associated with the level of renal function (Zoccali, 2006).Contrarily to the general population, where as much as the 75% of excess risk for coronary heart disease could be explained by classical risk factors (Magnus and Beaglehole, 2001), the excess of risk of CVD in CKD patients it is not so easy to explain. Furthermore, as renal function deteriorates, the risk increases linearly (Weiner et al., 2004). Understanding mechanisms underlying CKD is fundamental to develop novel treatments for this disease and its complications. In recent years, bioinformatics has emerged as a powerful tool for providing comprehensive insights into the molecular mechanisms of disease and identifying potential biomarkers and therapeutic targets. Novel methods, such as bioinformatics analyses applied to genome and proteome, might help in identifying new, unknowns, pathways.

Proteome

10.3389/fcell.2021.712834

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Λοιμώξεις ληπτών νεφρικού αλλομοσχεύματος: ταξινόμηση, αιτιολογία και κλινική εικόνα - Infectious diseases in renal transplant recipients: classification, etiology and clinical manifestations.

Ελληνική Νεφρολογία - Hellenic Nephrology (2016)

Ν.Α. Αναστασόπουλος Φ. Ζαρζουλάς Α. Ντούνη Ε. Ντουνούση Ν.Α. Αναστασόπουλος

Etiology

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