Hongshuang Pan

Henan Agricultural University

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Tingting Yu

Yantai University

Yanqiu Meng

Shenyang University of Chemical Technology

Weichen Zhang

Nanjing University of Chinese Medicine

Lina Yang

University of California, San Diego

Ruimin Qiao

Henan Agricultural University

Jinyi Han

Sanya University

Hua-Bo Cui

Shenyang University of Chemical Technology

Xiaohan Wang

Qingdao University

Xinjian Li

Henan Agricultural University

Haoyi Feng

Hebei University of Technology

Cooperative Institutions

Henan Agricultural University

Zhejiang University

Chinese Academy of Sciences

University of Chinese Academy of Sciences

Nanjing Medical University

Sanya University

Shenyang University of Chemical Technology

Ministry of Agriculture and Rural Affairs

Chinese Academy of Medical Sciences & Peking Union Medical College

Central South University

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Synthesis and antitumor activity evaluation of asiatic acid derivatives as survivin inhibitor

Journal of Asian Natural Products Research (2018)

Yanqiu Meng Hua-Bo Cui Lei Li Weichen Zhang Hongshuang Pan

A series of asiatic acid derivatives were synthesized and their cytotoxicities in vitro against two cancer cell lines (HepG2 and SGC7901) were evaluated by MTT assay. The results showed that compounds I2, I6, and II6 have more potent anticancer activity than that of the positive control drug paclitaxel. The interactions between the compounds I2, I6, and II6 and survivin were also studied by docking simulations.

Survivin

MTT assay

Docking (animal)

Cancer cell lines

Positive control

Anticancer drug

10.1080/10286020.2017.1405940

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Citations (8)

Effect of L-proline on sperm quality during cryopreservation of boar semen

Animal Reproduction Science (2023)

Chuang Liu Haoyi Feng Jinyi Han Hao Zhou Liwei Yuan

Malondialdehyde

BOAR

Semen Analysis

10.1016/j.anireprosci.2023.107359

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Citations (8)

An action cycle of empowerment evaluation: Feasibilities and challenges.

Hongshuang Pan Hui-Ling Wendy Pan

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Research Progress on Antitumor Action Mechanism of Ursolic Acid

Yanqiu Meng Lina Yang Hongshuang Pan Tingting Yu Weichen Zhang

Ursolic Acid is a type of pentacyclic triterpene compounds with many kinds of pharmacological activities, especially its antitumor activity. The antitumor mechanism of ursolic acid is multifaceted. In this paper, the research progress of anti-tumor mechanism of ursolic acid has been reviewed and forecasted.

Ursolic acid

Mechanism of Action

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