Assunta D’Amato

University of Salerno

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Co-Authors

Irene Izzo

University of Salerno

Giorgio Della Sala

University of Salerno

Francesco De Riccardis

University of Salerno

Chiara Costabile

University of Salerno

Giovanni Pierri

University of Salerno

Consiglia Tedesco

University of Salerno

Pasquale Longo

University of Salerno

Annaluisa Mariconda

University of Basilicata

Rosaria Schettini

University of Salerno

Jessica Ceramella

University of Calabria

Cooperative Institutions

University of Salerno

University of Naples Federico II

University of Calabria

National Interuniversity Consortium of Materials Science and Technology

Consorzio Interuniversitario Reattività Chimica e Catalisi

Istituto di Chimica Biomolecolare

Novartis (Italy)

Novartis (Switzerland)

Utrecht University

University of Florence

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Cyclic hexameric cyclopeptoids as mimics of enniatins and beauvericin mycotoxins

Assunta D’Amato Raffaele Volpe Giorgio Della Sala Irene Izzo Francesco De Riccardis

Beauvericin

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CCDC 1941542: Experimental Crystal Structure Determination

The Cambridge Structural Database (2019)

Rosaria Schettini Assunta D’Amato Giovanni Pierri Consiglia Tedesco Giorgio Della Sala

10.5517/ccdc.csd.cc235bd1

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Chitosan-Based Schiff Bases (CSBs) and Their Metal Complexes: Promising Antimicrobial Agents

Molecules (2025)

Domenico Iacopetta Alessia Catalano Jessica Ceramella Annaluisa Mariconda Assunta D’Amato

The scientific interest in the chemical modification of chitosan to increase its solubility and application has led to its conjugation with Schiff bases, which are interesting scaffolds endowed with diverse biological properties. The resultant chitosan-based Schiff bases (CSBs) are widely studied in scientific literature due to the myriad of activities exerted, both catalytic and biological, including anticancer, anti-inflammatory, antioxidant, and especially antimicrobial ones. Antimicrobial resistance (AMR) is one of the major public health challenges of the twenty-first century because it represents a threat to the prevention and treatment of a growing number of bacterial, parasitic, viral, and fungal infections that are no longer treatable with the available drugs. Thus, in this review, we present a brief outline of the biological activities of CSBs as well as their complexes with metals, with a particular focus on the recent literature regarding the antimicrobial effect of these captivating derivatives.

10.3390/molecules30020207

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CCDC 1941540: Experimental Crystal Structure Determination

The Cambridge Structural Database (2019)

Rosaria Schettini Assunta D’Amato Giovanni Pierri Consiglia Tedesco Giorgio Della Sala

Crystal Structures

Continuous Crystallization

Structure Determination

Ultrasound-Assisted Crystallization

Crystallography

10.5517/ccdc.csd.cc235bbz

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Macrocyclic Triazolopeptoids: A Promising Class of Extended Cyclic Peptoids

Organic Letters (2022)

Alicja M. Araszczuk Assunta D’Amato Rosaria Schettini Chiara Costabile Giorgio Della Sala

Head-to-tail cyclization of linear oligoamides containing 4-benzylaminomethyl-1H-1,2,3-triazol-1-yl acetic acid monomers afforded a novel class of "extended macrocyclic peptoids". The identification of the conformation in solution for a cyclodimer and the X-ray crystal structure of a cyclic tetraamide are reported.

Cyclic peptide

10.1021/acs.orglett.2c03062

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Front Cover: Structure – Bioactivity Relationship in Cyclic Peptoids: An Overview (Eur. J. Org. Chem. 38/2022)

European Journal of Organic Chemistry (2022)

Assunta D’Amato

The Front Cover shows a panorama from the so-called Path of the Gods, a hiking trail in Southern Italy. At the end of the strenuous journey, the trekker is rewarded with a wonderful view of the Amalfi coast. The path to developing (cyclic) peptoids as therapeutic agents is still an uphill hike, but the tremendous advances made in the last few decades in terms of both varied biological activity and structural diversity make them a rather promising class of peptidomimetic drug candidates. More information can be found in the Review by Assunta D'Amato.

Front cover

Peptidomimetic

Panorama

10.1002/ejoc.202201099

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CCDC 1588738: Experimental Crystal Structure Determination

The Cambridge Structural Database (2018)

Assunta D’Amato Giovanni Pierri Chiara Costabile Giorgio Della Sala Consiglia Tedesco

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Crystal (programming language)

10.5517/ccdc.csd.cc1qb6mw

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CCDC 1910908: Experimental Crystal Structure Determination

The Cambridge Structural Database (2019)

Assunta D’Amato Giovanni Pierri Consiglia Tedesco Giorgio Della Sala Irene Izzo

10.5517/ccdc.csd.cc224g6x

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CCDC 1941541: Experimental Crystal Structure Determination

The Cambridge Structural Database (2019)

Rosaria Schettini Assunta D’Amato Giovanni Pierri Consiglia Tedesco Giorgio Della Sala

10.5517/ccdc.csd.cc235bc0

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Diarylureas: New Promising Small Molecules against Streptococcus mutans for the Treatment of Dental Caries

Antibiotics (2023)

Domenico Iacopetta Jessica Ceramella Alessia Catalano Assunta D’Amato Graziantonio Lauria

Dental caries is a biofilm-mediated disease that represents a worldwide oral health issue. Streptococcus mutans has been ascertained as the main cariogenic pathogen responsible for human dental caries, with a high ability to form biofilms, regulated by the quorum sensing. Diarylureas represent a class of organic compounds that show numerous biological activities, including the antimicrobial one. Two small molecules belonging to this class, specifically to diphenylureas, BPU (1,3-bis[3,5-bis(trifluoromethyl)phenyl]urea) and DMTU (1,3-di-m-tolyl-urea), showed interesting results in studies regarding the antimicrobial activity against the cariogenic bacterium S. mutans. Since there are not many antimicrobials used for the prevention and treatment of caries, further studies on these two interesting compounds and other diarylureas against S. mutans may be useful to design new effective agents for the treatment of caries with generally low cytotoxicity.

Dental plaque

10.3390/antibiotics12010112

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Citations (16)