Chao Zeng

Xiangya Hospital Central South University

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Co-Authors

Guanghua Lei

Central South University

181

Jie Wei

Xiangya Hospital Central South University

142

Tuo Yang

Xiangya Hospital Central South University

Yilun Wang

Xiangya Hospital Central South University

Shuguang Gao

Xiangya Hospital Central South University

Yuqing Zhang

Capital Medical University

Hui Li

Xiangya Hospital Central South University

Dongxing Xie

Xiangya Hospital Central South University

Michael Doherty

University of Nottingham

Weiya Zhang

Hefei Institutes of Physical Science

Cooperative Institutions

Central South University

265

Xiangya Hospital Central South University

196

Chinese Academy of Sciences

Peking University

Sichuan University

Air Force Medical University

Harvard University

Chinese Academy of Medical Sciences & Peking Union Medical College

Second Xiangya Hospital of Central South University

Sun Yat-sen University

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Association Between Gut Microbiota and Elevated Serum Urate in Two Independent Cohorts

Arthritis & Rheumatology (2021)

Jie Wei Yuqing Zhang Nicola Dalbeth Robert Terkeltaub Tuo Yang

Objective Hyperuricemia is a precursor to gout and is often present in other metabolic diseases that are promoted by microbiome dysbiosis. We undertook this study to examine the association of gut microbiota with hyperuricemia and serum urate levels in humans. Methods Study participants were derived from a community‐based observational study, the Xiangya Osteoarthritis Study (discovery cohort). Hyperuricemia was defined as the presence of a serum urate level >357 μmoles/liter in women and >416 μmoles/liter in men. Gut microbiota were analyzed using 16S ribosomal RNA sequencing of stool samples. We examined the relationship of microbiota dysbiosis (i.e., richness, diversity, composition, and relative abundance of microbiota taxa) and predicted functional pathways to prevalent hyperuricemia and serum urate levels. We verified the associations in an independent observational study, the Step Study (validation cohort). Results The discovery cohort consisted of 1,392 subjects from rural areas (mean age 61.3 years, 57.4% women, 17.2% with hyperuricemia). Participants with hyperuricemia had decreased richness and diversity, altered composition of microbiota, and lower relative abundances of genus Coprococcus compared to those with normouricemia. Predicted KEGG metabolism pathways including amino acid and nucleotide metabolisms were significantly altered in subjects with hyperuricemia compared to those with normouricemia. Gut microbiota richness, diversity, and low relative abundances of genus Coprococcus were also associated with high levels of serum urate. These findings were replicated in the validation cohort with 480 participants. Conclusion Gut microbiota dysbiosis is associated with elevated serum urate levels. Our study examines the possibility that microbiota dysbiosis may modulate these levels.

Association (psychology)

10.1002/art.42009

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Citations (66)

Genetically predicted vitamin K levels and risk of osteoarthritis: Mendelian randomization study

Seminars in Arthritis and Rheumatism (2022)

Sizheng Steven Zhao Jonas Bovijn David M. Hughes Tinting Sha Chao Zeng

Osteoarthritis (OA) is a progressive disease for which there is no disease modifying therapy. Vitamin K levels and vitamin K antagonism have been associated with risk and progression of OA which may have direct implications for clinical management, but these observational findings are susceptible to confounding. We aimed to estimate the causal association between vitamin K and OA risk using Mendelian randomisation (MR).We used data from the largest genome-wide association study (GWAS) of OA to date (up to 826,690 individuals) to estimate the effect of genetically predicted vitamin K level (instrumented using four variants derived from a GWAS of 2,138 individuals) on risk of all OA types, knee, hip, spine, hand OA, and total joint replacement. We employed the inverse-variance weighted method for the primary analysis and, in a series of sensitivity analyses, adjusted for sub-genome wide significant instruments and tested for potential bias from pleiotropy.We showed that genetically predicted vitamin K levels were not causally associated with risk of OA overall (OR 0.98 per unit increase in log-transformed vitamin K1; 95%CI 0.96-1.01), knee (OR 0.98; 0.92-1.03), hip (OR 0.97; 0.88-1.07), spine (OR 0.97; 0.90-1.04), hand OA (OR 0.97; 0.91-1.04) or joint replacement (OR 0.96; 0.89-1.04). Results were similar across all sensitivity analyses.We found little evidence of a causal association between genetically predicted vitamin K and OA risk. Larger genetic and interventional studies of vitamin K are required to confirm our findings.

Mendelian Randomization

Genome-wide Association Study

Pleiotropy

Genetic Association

10.1016/j.semarthrit.2022.152030

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Citations (7)

Is chondroitin sulfate plus glucosamine superior to placebo in the treatment of knee osteoarthritis?

Annals of the Rheumatic Diseases (2015)

Chao Zeng Jie Wei Guanghua Lei

We read with interest the article by Hochberg et al 1 related to the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain. The study suggested that CS+GH has comparable efficacy to celecoxib in reducing pain, stiffness, functional limitation and joint swelling/effusion after 6 months with a good safety profile. These results were ‘promising’. We really appreciate the work that was done by the authors. However, there are worthwhile issues that need to be explored. The study was designed as a non-inferiority trial without placebo arm. The authors explained that, ‘The use of a placebo group was not considered …

Celecoxib

Chondroitin

Knee pain

Joint pain

10.1136/annrheumdis-2015-207476

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Citations (4)

Weight loss after initiating anti‐obesity medications and gout among overweight and obesity individuals: a population‐based cohort study

Arthritis & Rheumatology (2024)

Jie Wei Yilun Wang Nicola Dalbeth Junqing Xie Jing Wu

Weight loss is conditionally recommended for gout management; however, its impact on incident gout and recurrent gout flares among individuals who were overweight and obese remains unknown. We investigate the relationship between weight loss rate following treatment with anti-obesity medications and the risk of incident gout and recurrent gout flares among individuals who were overweight or obese.

Orlistat

10.1002/art.42996

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Citations (2)

Overactivated autophagy contributes to steroid-induced avascular necrosis of the femoral head

Experimental and Therapeutic Medicine (2017)

Xuan'An Li Yusheng Li Liangjun Li Xi Xie Ye Yang

Steroid-induced avascular necrosis of the femoral head (SANFH) is a mainly bilateral complication of steroid therapy that involves extensive necrosis, and frequently occurs in young and middle-aged individuals, with a high disability rate. Autophagy is an intracellular lysosomal degradation process occurring in numerous diseases. However, the effect of dexamethasone (DXM)-induced autophagy on osteoblasts is unclear. The aim of the present study was to investigate the effects of autophagy on SANFH. In the present study, femoral head of SANFH patients was collected, and the autophagy in the samples was evaluated. In addition, cell proliferation, membrane integrity and differentiation of osteoblasts were also detected to confirm the effect of DXM on a mouse osteoblasts cell MC3T3-E1 in vitro. Beclin 1 and microtubule-associated protein 1 light chain 3 were used as the markers of autophagy, while the autophagy inhibitor 3-methyladenine (3-MA) was used to investigate the role of autophagy in DXM-challenged osteoblasts. Immunohistochemistry results demonstrated that Beclin1 was markedly increased in the femoral head of SANFH patients. Furthermore, the treatment of osteoblasts with DXM decreased cell viability, increased lactate dehydrogenase activity in the cell culture supernatant, and reduced the alkaline phosphatase activity and bone morphogenetic protein-2 expression in osteoblasts in vitro. By contrast, 3-MA treatment attenuated the cell injury induced by DXM. The present study indicates that overactivated autophagy may be an important factor contributing to SANFH, and autophagy may be a potential target for the prevention of SANFH.

Avascular Necrosis

Osteocyte

10.3892/etm.2017.4508

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Citations (16)

Risk factor heterogeneity for medial and lateral compartment knee osteoarthritis: analysis of two prospective cohorts

Osteoarthritis and Cartilage (2018)

Jie Wei Douglas P. Gross Nancy E. Lane Na Lu Min Wang

10.1016/j.joca.2018.12.013

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Citations (25)

Editorial Commentary: Hip Arthroscopy in Patients With Moderate to Advanced Osteoarthritis Shows Unpredictable Results

Arthroscopy The Journal of Arthroscopic and Related Surgery (2023)

Yilin Xiong Chao Zeng Guanghua Lei

Hip Arthroscopy

Femoroacetabular Impingement

Concomitant

Hip surgery

Grading (engineering)

10.1016/j.arthro.2022.09.006

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Citations (1)

Association Between Hyperuricemia and Ultrasound‐Detected Hand Synovitis

Arthritis Care & Research (2024)

Ting Jiang Qianlin Weng Yuqing Zhang Weiya Zhang Michael Doherty

Although hand synovitis is prevalent in the older population, the etiology remains unclear. Hyperuricemia, a modifiable metabolic disorder, may serve as an underlying mechanism of hand synovitis, but little is known about their relationship. We assessed the association between hyperuricemia and hand synovitis in a large population-based sample.

10.1002/acr.25342

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Citations (2)

Clinical Significance of HSCARG for Atherosclerotic Coronary Heart Disease and Reduced ROS-Oxidative Stress in in Vivo and in Vitro Models via p47phox by NF-κB Activity

Brazilian Journal of Cardiovascular Surgery (2022)

Xiaofang Zhou Siwei Zhou Yuanmei Li Zhiyong Qian Chao Zeng

Coronary heart disease (CHD) is a dynamic process in which there are interactions between endothelial dysfunction, oxidative stress, and inflammatory responses. The aim of the present study was to investigate the function and mechanism of HSCARG in the treatment of CHD.Male apolipoprotein E/low-density lipoprotein receptor-deficient mice were given a high-fat diet with 21% fat and 0.15% cholesterol for the in vivo model. Human umbilical vein endothelial cells were incubated with angiotensin II for the in vitro model. HSCARG expression was inhibited in patients or mice with CHD.HSCARG reduced oxidative stress in mice with CHD. HSCARG also reduced reactive oxygen species (ROS)-oxidative stress in the in vitro model. HSCARG induced p47phox expression in the in vitro model by NF-κB activity. The regulation of nuclear factor kappa B (NF-κB) activity or p47phox expression participates in the effects of HSCARG in CHD.Altogether, our data indicate that HSCARG reduced ROS-oxidative stress in in vivo and in vitro models of CHD via p47phox by NF-κB activity and may be a clinical target for CHD.

Endothelial Dysfunction

10.21470/1678-9741-2021-0183

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Citations (1)

The influence of the intercondylar notch dimensions on injury of the anterior cruciate ligament: a meta-analysis

Knee Surgery Sports Traumatology Arthroscopy (2012)

Chao Zeng Shuguang Gao Jie Wei Tubao Yang Ling Jie Cheng

ACL injury

10.1007/s00167-012-2166-4

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Citations (87)