Mahboubeh Nabavinia

Nationwide Children's Hospital

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Baishali Kanjilal

University of California, Riverside

Mitchel R. Stacy

Nationwide Children's Hospital

Ali Khademhosseini

University of California, Los Angeles

Iman Noshadi

University of California, Riverside

Ting‐Heng Chou

National Taipei University of Nursing and Health Science

Ali Tamayol

University of Nebraska–Lincoln

Mariano Savelski

Rowan University

Christopher K. Breuer

Nationwide Children's Hospital

Hakimeh Sharififard

Yasouj University

Arameh Masoumi

University of California, Riverside

Cooperative Institutions

Nationwide Children's Hospital

Harvard University

Brigham and Women's Hospital

The Ohio State University

Massachusetts Institute of Technology

Harvard–MIT Division of Health Sciences and Technology

Innovation Research Center

Shiraz University

The Ohio State University Wexner Medical Center

Rowan University

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Successful Orthotopic Liver Transplantation in Mice Utilizing Microcomputed Tomography Angiography

Journal of Visualized Experiments (2023)

Qiang Zeng Doug A. Gouchoe Mahboubeh Nabavinia Yong Gyu Lee Xi Wang

Microcomputed tomography (microCT) angiography is an invaluable resource to researchers. New advances in this technology have allowed for high-quality images to be obtained of micro-vasculature and are high-fidelity tools in the field of organ transplantation. In this model of orthotopic liver transplantation (OLT) in mice, microCT affords the opportunity to evaluate allograft anastomosis in real time and has the added benefit of not having to sacrifice study animals. The choice of contrast, as well as image acquisition settings, create a high-definition image, which gives researchers invaluable information. This allows for evaluation of the technical aspects of the procedure as well as potentially evaluating different therapeutics over an extended duration of time. In this protocol, we detail an OLT model in mice in a stepwise fashion and finally describe a microCT protocol that can give high-quality images, which aid researchers in in-depth analysis of solid organ transplantation. We provide a step-by-step guide for liver transplantation in a mouse, as well as briefly discuss a protocol for evaluating the patency of the graft through microCT angiography.

Computed Tomography Angiography

10.3791/65537

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Tissue engineered vascular grafts are resistant to the formation of dystrophic calcification

Nature Communications (2024)

M Turner Kevin M. Blum Tatsuya Watanabe Erica L. Schwarz Mahboubeh Nabavinia

Abstract Advancements in congenital heart surgery have heightened the importance of durable biomaterials for adult survivors. Dystrophic calcification poses a significant risk to the long-term viability of prosthetic biomaterials in these procedures. Herein, we describe the natural history of calcification in the most frequently used vascular conduits, expanded polytetrafluoroethylene grafts. Through a retrospective clinical study and an ovine model, we compare the degree of calcification between tissue-engineered vascular grafts and polytetrafluoroethylene grafts. Results indicate superior durability in tissue-engineered vascular grafts, displaying reduced late-term calcification in both clinical studies ( p < 0.001) and animal models ( p < 0.0001). Further assessments of graft compliance reveal that tissue-engineered vascular grafts maintain greater compliance ( p < 0.0001) and distensibility ( p < 0.001) than polytetrafluoroethylene grafts. These properties improve graft hemodynamic performance, as validated through computational fluid dynamics simulations. We demonstrate the promise of tissue engineered vascular grafts, remaining compliant and distensible while resisting long-term calcification, to enhance the long-term success of congenital heart surgeries.

Polytetrafluoroethylene

Vascular graft

10.1038/s41467-024-46431-4

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Quantification of Skeletal Muscle Perfusion in Peripheral Artery Disease Using ¹⁸ F‐Sodium Fluoride Positron Emission Tomography Imaging

Journal of the American Heart Association (2024)

Ting‐Heng Chou Mahboubeh Nabavinia Nguyen K. Tram Eleanor T. Rimmerman Surina Patel

Background Perfusion deficits contribute to symptom severity, morbidity, and death in peripheral artery disease (PAD); however, no standard method for quantifying absolute measures of skeletal muscle perfusion exists. This study sought to preclinically test and clinically translate a positron emission tomography (PET) imaging approach using an atherosclerosis‐targeted radionuclide, fluorine‐18‐sodium fluoride ( 18 F‐NaF), to quantify absolute perfusion in PAD. Methods and Results Eight Yorkshire pigs underwent unilateral femoral artery ligation and dynamic 18 F‐NaF PET/computed tomography imaging on the day of and 2 weeks after occlusion. Following 2‐week imaging, calf muscles were harvested to quantify microvascular density. PET methodology was validated with microspheres in 4 additional pig studies and translated to patients with PAD (n=39) to quantify differences in calf perfusion across clinical symptoms/stages and perfusion responses in a case of revascularization. Associations between PET perfusion, ankle‐brachial index, toe‐brachial index, and toe pressure were assessed in relation to symptoms. 18 F‐NaF PET/computed tomography quantified significant deficits in calf perfusion in pigs following arterial occlusion and perfusion recovery 2 weeks after occlusion that coincided with increased muscle microvascular density. Additional studies confirmed that PET‐derived perfusion measures agreed with microsphere‐derived perfusion measures. Translation of imaging methods demonstrated significant decreases in calf perfusion with increasing severity of PAD and quantified perfusion responses to revascularization. Perfusion measures were also significantly associated with symptom severity, whereas traditional hemodynamic measures were not. Conclusions 18 F‐NaF PET imaging quantifies perfusion deficits that correspond to clinical stages of PAD and represents a novel perfusion imaging strategy that could be partnered with atherosclerosis‐targeted 18 F‐NaF PET imaging using a single radioisotope injection. Registration URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03622359.

10.1161/jaha.123.031823

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Recent Progress in Iron Oxide Nanoparticles as Therapeutic Magnetic Agents for Cancer Treatment and Tissue Engineering

ACS Applied Bio Materials (2020)

Mahboubeh Nabavinia Juan Beltran‐Huarac

The positive response of superparamagnetic iron oxide nanoparticles (SPIONs), in terms of biodegradability, circulation, elimination, toxicity, and manipulation of their structure/activity relationship, has enabled them to find their way into commercialization as an iron supplement, MRI contrast agents, MPI tracers, and hyperthermia and magneto-mechanical actuators. This Review focuses on the most current progress regarding the application of SPIONs as magnetic therapeutic agents for cancer treatment and tissue engineering. Because of their superior magnetic anisotropy, irreversibility of high- and low-field magnetization, and superparamagnetic ordering at corporal temperatures, they exhibit the unique ability to respond to theraputic doses (e.g., in magnetic hyperthermia and targeted drug delivery). This Review discusses the role of SPIONs to enhance chemotherapy and radiotherapy efficiency and specificity and how this enhancement could mitigate some side effects. SPIONs applied as tools for gene delivery, immunotherapy, and tissue engineering are also reviewed in the context of their potential to translational medicine. Lastly, some emerging issues concerning SPION toxicity are summarized and how they are being addressed to achieve success in clinical applications is discussed.

Magnetic hyperthermia

Iron oxide nanoparticles

10.1021/acsabm.0c00947

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A comparative investigation on removal performances of commercial activated carbon, chitosan biosorbent and chitosan/activated carbon composite for cadmium

Chemical Engineering Journal (2012)

Shahin Hydari Hakimeh Sharififard Mahboubeh Nabavinia Mohammad Reza Parvizi

Langmuir adsorption model

Carbon fibers

10.1016/j.cej.2012.04.057

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Citations (194)

Abstract 17441: Non-Invasive Quantification of Peripheral Angioplasty-Induced Vascular Inflammation in a Porcine Model Using PET/CT Imaging

Circulation (2023)

Mahboubeh Nabavinia Eleanor T. Rimmerman Corrin Mansfield Ting‐Heng Chou Michael R. Go

Background: Similarities in peripheral vascular anatomy between swine and humans make this animal an ideal model for evaluating the effects of lower extremity angioplasty procedures commonly performed to improve limb blood flow in peripheral artery disease (PAD). Hypothesis: We hypothesized that PET/CT imaging would provide a non-invasive strategy for quantifying the inflammatory response to balloon overdilation injury in a swine model of peripheral angioplasty. Methods: Five Yorkshire pigs (weight = 25 kg) underwent overdilation of the right femoral artery. A balloon catheter (7 mm x 40 mm) was introduced via the carotid artery and guided to the femoral artery under fluoroscopy. The balloon was then inflated to a pressure 1.5 times greater the recommended nominal pressure to induce arterial injury. 18 F-fluorodeoxyglucose (FDG) PET/CT imaging was performed 14 days after angioplasty to quantify in vivo inflammation in the injured and control femoral arteries, which was expressed as the maximum standardized uptake value (SUV max ). Pigs were euthanized 14 days post-angioplasty and arteries were harvested and sectioned for gamma counting ( 18 F-FDG uptake), and stained with hematoxylin and eosin histology (H&E), Masson’s trichrome, and alpha-smooth muscle actin (α-SMA) for evaluation of intimal remodeling and smooth muscle cell proliferation. Results: 18 F-FDG PET/CT imaging quantified a significant increase in inflammation for the injured versus control femoral artery 14 days post-angioplasty (p=0.04). Gamma counting confirmed a significant increase in 18 F-FDG uptake in the injured artery (p=0.02). H&E revealed a significant increase in intimal thickening in the injured artery (p=0.03). α-SMA expression was also significantly increased in the injured versus control femoral artery (p=0.01), demonstrating an increase in smooth muscle cell proliferation. Conclusions: 18 F-FDG PET/CT quantifies arterial inflammation resulting from overdilation injury that is associated with intimal remodeling and smooth muscle cell proliferation. PET/CT imaging may provide a non-invasive strategy for in vivo testing of the efficacy of emerging drug-coated endovascular peripheral devices.

Masson's trichrome stain

Standardized uptake value

10.1161/circ.148.suppl_1.17441

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Synthesis and evaluation of catalytic application of porous resin

Mahboubeh Nabavinia

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Contributors

Elsevier eBooks (2020)

Brahim Achiou Morteza Afkhamipour Ali Ahmadi Meisam Ansarpour Manuel Bailera

10.1016/b978-0-12-819657-1.09991-6

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Stem Cell Biology and Regenerative Medicine

Mehdi Razavi Abdulmonem Alshihri Ding Weng Fatemeh Khatami Julio Aleman

Regenerative Medicine

Stem cell biology

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A Textile Dressing for Temporal and Dosage Controlled Drug Delivery

Advanced Functional Materials (2017)

Pooria Mostafalu Gita Kiaee Giorgio Giatsidis Akbar Khalilpour Mahboubeh Nabavinia

Abstract Chronic wounds do not heal in an orderly fashion in part due to the lack of timely release of biological factors essential for healing. Topical administration of various therapeutic factors at different stages is shown to enhance the healing rate of chronic wounds. Developing a wound dressing that can deliver biomolecules with a predetermined spatial and temporal pattern would be beneficial for effective treatment of chronic wounds. Here, an actively controlled wound dressing is fabricated using composite fibers with a core electrical heater covered by a layer of hydrogel containing thermoresponsive drug carriers. The fibers are loaded with different drugs and biological factors and are then assembled using textile processes to create a flexible and wearable wound dressing. These fibers can be individually addressed to enable on‐demand release of different drugs with a controlled temporal profile. Here, the effectiveness of the engineered dressing for on‐demand release of antibiotics and vascular endothelial growth factor (VEGF) is demonstrated for eliminating bacterial infection and inducing angiogenesis in vitro. The effectiveness of the VEGF release on improving healing rate is also demonstrated in a murine model of diabetic wounds.

Wound dressing

Textile

Chronic wound

On demand

10.1002/adfm.201702399

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Citations (222)