V. F. Rudchenko

Research Field

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Citations (9)

Asymmetric unbridged nitrogen. 39. Configuration and conformations of N-substituted perhydro-1, 3,2-dioxazines

Chemistry of Heterocyclic Compounds (1985)

A. B. Zolotoi O.A. Dyachenko И. И. Червин V. F. Rudchenko L. O. Atovmyan

10.1007/bf00515246

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ChemInform Abstract: An Electrophilically Catalyzed Cleavage of Dimethoxyamine into the Methoxynitrenium Ion and Its Reactions.

ChemInform (1991)

V. F. Rudchenko S. M. Ignatov И. И. Червин Abil E. Aliev R. G. Kostyanovskii

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Cleavage (geology)

10.1002/chin.199110067

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Data from F-aza-T-dCyd (NSC801845), a Novel Cytidine Analog, in Comparative Cell Culture and Xenograft Studies with the Clinical Candidates T-dCyd, F-T-dCyd, and Aza-T-dCyd

Joel Morris Donn G. Wishka Omar D. Lopez V. F. Rudchenko Guangfei Huang

<div>Abstract<p>In this article, 5-aza-4′-thio-2′-β-fluoro-2′-deoxycytidine (F-aza-T-dCyd, NSC801845), a novel cytidine analog, is first disclosed and compared with T-dCyd, F-T-dCyd, and aza-T-dCyd in cell culture and mouse xenograft studies in HCT-116 human colon carcinoma, OVCAR3 human ovarian carcinoma, NCI-H23 human NSCLC carcinoma, HL-60 human leukemia, and the PDX BL0382 bladder carcinoma. In three of five xenograft lines (HCT-116, HL-60, and BL-0382), F-aza-T-dCyd was more efficacious than aza-T-dCyd. Comparable activity was observed for these two agents against the NCI-H23 and OVCAR3 xenografts. In the HCT-116 study, F-aza-T-dCyd [10 mg/kg intraperitoneal (i.p.), QDx5 for four cycles], produced complete regression of the tumors in all mice with a response that proved durable beyond postimplant day 150 (129 days after the last dose). Similarly, complete tumor regression was observed in the HL-60 leukemia xenograft when mice were dosed with F-aza-T-dCyd (10 mg/kg i.p., QDx5 for three cycles). In the PDX BL-0382 bladder study, both oral and i.p. dosing of F-aza-T-dCyd (8 mg/kg QDx5 for three cycles) produced regressions that showed tumor regrowth beginning 13 days after dosing. These findings indicate that further development of F-aza-T-dCyd (NSC801845) is warranted.</p></div>

Cytidine

10.1158/1535-7163.c.6543264

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Large-scale synthesis of galeterone and lead next generation galeterone analog VNPP433-3β

Steroids (2022)

Puranik Purushottamachar Elizabeth Thomas Retheesh S. Thankan V. F. Rudchenko Guangfei Huang

Dichloromethane

Imidazole

10.1016/j.steroids.2022.109062

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Citations (7)

Geminal systems. 15. Chemical properties of N-chloro-N-alkoxy-N-tert-alkylamines

Bulletin of the Academy of Sciences of the USSR Division of Chemical Science (1981)

Vasiliy G. Shtamburg V. F. Rudchenko Sh. S. Nasibov И. И. Червин А. П. Плешкова

Geminal

Azoxy

Nitroso Compounds

Nitroso

Nitrogen atom

Nitrosation

10.1007/bf00963421

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Citations (1)

ChemInform Abstract: Perhydro‐1,3,6,2‐trioxazocine.

ChemInform (1994)

V. F. Rudchenko И. И. Червин R. G. Kostyanovskii

10.1002/chin.199418171

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ChemInform Abstract: GEMINAL SYSTEMS. 16. REACTIONS OF N‐CHLORO‐N‐ALKOXY‐N‐TERT‐ALKYLAMINES WITH AMINES

Chemischer Informationsdienst (1982)

Vasiliy G. Shtamburg V. F. Rudchenko Sh. S. Nasibov И. И. Червин А. П. Плешкова

Abstract Durch Einwirkung von flüssigem Ammoniak bei 20°C in geschlossenem Gefäß erhält man in komplizierter Reaktionsfolge aus dem Carbonsäuremethylester (I) das Chlor‐isobuttersäureamid (II) und die Azoxyverbindung (III).

Geminal

10.1002/chin.198213147

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ChemInform Abstract: NEW SYNTHESIS OF 2‐ALKOXYISOXAZOLIDINES

Chemischer Informationsdienst (1980)

V. F. Rudchenko Vasiliy G. Shtamburg R. G. Kostyanovskii

Abstract Wie im Formelschema angegeben wird durch Reduktion und Cyclisierung aus γ‐Methoxyamino‐isovaleriansäure‐methyl‐ ester (I) das ′2‐Methoxy‐3,3‐dimethyl‐isoxazolidin (III) hergestellt.

10.1002/chin.198049201

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Supplementary Table T1 from F-aza-T-dCyd (NSC801845), a Novel Cytidine Analog, in Comparative Cell Culture and Xenograft Studies with the Clinical Candidates T-dCyd, F-T-dCyd, and Aza-T-dCyd

Joel Morris Donn G. Wishka Omar D. Lopez V. F. Rudchenko Guangfei Huang

<p>Supplementary Table T1</p>

Cytidine

Table (database)

10.1158/1535-7163.22522038

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