ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of 2-substituted pyrimidines. Studies directed toward the synthesis of the pyrimidine moiety of bleomycinWilliam K. Hagmann, Fatima Z. Basha, Mitsunori Hashimoto, R. Bruce Frye, Shosuke Kojo, and Sidney M. HechtCite this: J. Org. Chem. 1981, 46, 7, 1413–1423Publication Date (Print):March 1, 1981Publication History Published online1 May 2002Published inissue 1 March 1981https://pubs.acs.org/doi/10.1021/jo00320a037https://doi.org/10.1021/jo00320a037research-articleACS PublicationsRequest reuse permissionsArticle Views574Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic applications of N-acylamino-1,3-dienes. 10. Importance of allylic interactions and stereoelectronic effects in dictating the steric course of the reaction of iminium ions with nucleophiles. An efficient total synthesis of (.+-.)-gephyrotoxinLarry E. Overman, Dominique Lesuisse, and Mitsunori HashimotoCite this: J. Am. Chem. Soc. 1983, 105, 16, 5373–5379Publication Date (Print):August 1, 1983Publication History Published online1 May 2002Published inissue 1 August 1983https://pubs.acs.org/doi/10.1021/ja00354a031https://doi.org/10.1021/ja00354a031research-articleACS PublicationsRequest reuse permissionsArticle Views1675Altmetric-Citations85LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Abstract Die 5′‐Desoxyribomononucleotide (I) reagieren mit Anilin (II) in Gegenwart von Triphenylphosphin und 2,2′‐Dipyridyldisulfid in Ausbeuten zwischen 60 und 65% zu den Phosphorodianilidaten (III), aus denen durch Kondensation mit den Mononuc1eotiden (IV)‐in Gegenwart von Triphenylphosphin und 2,2′‐Dipyridyldisulfid die Dinucleotidphosphorodianilidate (V) erhalten werden (50‐75% Ausbeute).
Abstract In the presence of a catalytic amount of 2-cyclohexen-1-one, decarboxylation of α-amino acids proceeds smoothly and affords the corresponding amino compounds in good yields. Optically active amino compounds, (3R)-(−)-3-hydroxypyrrolidine and (2R)-(−)-2-hydroxypropylamine are obtained in 93% and 80% yields, respectively.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of oligothymidylates and nucleoside cyclic phosphates by oxidation-reduction condensationTeruaki Mukaiyama and Mitsunori HashimotoCite this: J. Am. Chem. Soc. 1972, 94, 24, 8528–8532Publication Date (Print):November 1, 1972Publication History Published online1 May 2002Published inissue 1 November 1972https://pubs.acs.org/doi/10.1021/ja00779a039https://doi.org/10.1021/ja00779a039research-articleACS PublicationsRequest reuse permissionsArticle Views700Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthetic peptides, designed from scratch, are valuable building blocks for the fabrication of artificial nanoscale architectures. In recent years, the designed peptides have been applied to intracellular applications such as protein labelling, controlling of protein activation and assembly, and as drug carriers, etc. This chapter summarizes some recent reports to highlight progress in the de novo design of coiled-coil peptides, small synthetic peptides, and β-sheet peptides used in living cells or in vivo.
An unusual and simple method of obtaining enantiomers under chemically and physically achiral conditions has been found in which preferential crystallization accompanied second order asymmetric transformation.
Abstract A total synthesis of coenzyme A by utilization of the oxidation-reduction condensation in each important steps is described. Adenosine 2′ ,3′ -cyclic phosphate 5′ -phosphoromorpholidate and pantethine, important intermediates of coenzyme A, were prepared starting from adenosine 2′ (3′-) phosphate and pantothenoic acid in 60% and 80% yields, respectively, mainly by the use of triphenylphosphine and 2,2′ -dipyridyl disulfide as coupling reagents.
