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Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi

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Cihan Yücel

Istanbul Eye Hospital

Serkan Ketenciler

Istanbul Eye Hospital

Uğur Gürcün

Adnan Menderes University

Berent Dışçıgıl

Adnan Menderes University

Hüseyin GEMALMAZ

Okmeydanı Eğitim ve Araştırma Hastanesi

Hasan Toz

Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi

Mehmet Köseoğlu

İstanbul Sabahattin Zaim Üniversitesi

Yusuf Kuserli

Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi

Altay Nihat Acar

Suleyman Demirel University

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Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi

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Sağlık Bilimleri Üniversitesi

Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi

Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi

Burdur Mehmet Akif Ersoy Üniversitesi

Istanbul Eye Hospital

Adnan Menderes University

Okmeydanı Eğitim ve Araştırma Hastanesi

Istanbul University

European Hospital

Cardiovascular Research Center

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The effects of folic acid on vascular reactivity in a hyperhomocysteinemic rat model

Anatolian Current Medical Journal (2021)

Melek Yılmaz Hüseyin GEMALMAZ Cihan Yücel Serkan Ketenciler Uğur Gürcün

Abstract Objective: This study aimed to investigate the antioxidant effects of folic acid and its effects on contraction and relaxation responses in rat aorta in hyperhomocysteinemic rats. Methods: Thirty-four male Wistar Albino rats were allocated into four groups. Rats in the hyperhomocysteinemia group (Group 1, n=9) received 1g/kg/day methionine via orogastric gavage for 30 days and then injected with intraperitoneal saline for the next 7 days. In the hyperhomocysteinemia+folic acid group (Group 2, n=9), following the administration of methionine for 30 days, folic acid (4mg/kg/day) was delivered intraperitoneally for 7 days. Sham group rats (Group 3, n=8) received orogastric saline for 30 days, which was followed by an IP injection of saline for another 7 days. Animals allocated into the folic acid group (Group 4, n= 7) had orogastric saline for 30 days and intraperitoneal folic acid for 7 days. After 5 weeks of treatment, blood samples were obtained, all animals were sacrificed, and hearts were harvested. Thoracic aortic segments were suspended on individual organ baths, and acetylcholine-induced (endothelium-dependent) relaxation responses of isolated aortic rings were evaluated. Results: Relaxation responses in Group 1 thru 4 were 73.889.96, 76.159.28, 76.618.83, and 69.2615.68, respectively. There was no significant difference in the organ bath in terms of relaxation response to acetylcholine at a dose of 10-9 mM between the groups (F=0.716, p=0.550). Conclusion: Folic acid therapy failed to produce a significant improvement in vascular reactivity. Keywords: Hyperhomocysteinemia, folic acid, vascular reactivity

Hyperhomocysteinemia

Intraperitoneal injection

10.38053/acmj.880037

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Ecmo 360°

Melek Yılmaz Ülkü Kafa Kulaçoğlu Cihan Yücel Abdül Kerim Buğra Elif Güneysu

ECMO Geçmiş, Bugün ve Gelecek Melek YILMAZ ECMO Fizyolojisi Ülkü KAFA KULAÇOĞLU Endikasyonlar Kontrendikasyonlar Güncel Kılavuzlar Cihan YÜCEL ECMO Ekipmanları, Set Gereksinimleri ve Kurulum Tarık DEMİR Genel Prensipler, Kanulasyon ve Dekanulasyon Abdul Kerim BUĞRA Venoarteriyel ECMO Elif GÜNEYSU Candan ÖZTÜRK Venö-Venöz ECMO Serkan KETENCİLER ECMO Tedavisinde Takip ve Yönetim Burçin ÇAYHAN KARADEMİR ECMO’dan Ayrılma, Kriterler ve İşleyiş Timuçin AKSU ECMO ve Renal Replasman Tedavileri Burak ERSOY Pulmoner Embolizmde ECMO ve ECMO destekli girişimler Mehmed YANARTAŞ ECMO Destekli Kardiyopulmoner Resusitasyon: E-CPR Öner BOZAN Göğüs Cerrahisinde ECMO Onur DERDİYOK ECMO ve Plazmaferez Emre YAŞAR ECMO Mekanik Komplikasyonları Mehmet ATAY ECMO Hastalarında Nörolojik Komplikasyonlar Zeynep Vildan OKUDAN ATAY ECMO’nun Ventriküler Destek Cihazları ve Transplantasyona Köprü Aşamasındaki Rolü Aybala TONGUT Mobil ECMO: Kritik Hasta Transferindeki Rolü Okan UĞURLU ECMO Sırasında Gelişen Spesifik Sorunlar ve Çözümleri Behzat TÜZÜN COVID-19 Pandemisinde ECMO Haluk Mevre ÖZGÖZ ECMO Eğitiminde Simulasyonun Rolü Ercan SERVET ECMO Takımı Organizasyonu ve Çalışma İlkeleri Mobil ECMO Takımı Ali ARIKAN ECMO Hemşire Takibi Meral EKŞİOĞLU ECMO Sonuçları: Sağ Kalım ve Hayat Kalitesi İbrahim YILDIZHAN ECMO Koagulasyon Yönetimi Güncel Tartışmalar Meliha Zeynep KAHRAMAN ECMO ve İnflamatuar Yanıt Z.Özlem ULUBAY ECMO ve Sağlık Ekonomisi Canan METINOĞLU GÜRSOY Mete GÜRSOY ECMO ve Etik Hususlar Yusuf ÇETİN Anıl AKBAŞ Uyanık ECMO Mehmet KÖSEOĞLU Miyokarditte ve Nadir Kardiyomiyopatilerde ECMO Ali Aycan KAVALA Yusuf KUSERLİ Onur Emre SATILMIŞ İlaç Zehirlenmesinde ECMO Saygın TÜRKYILMAZ Hasan TOZ Selim TÜMKAYA Hipotermi İçin ECMO Yusuf KUSERLİ Mehmet Ali YEŞİLTAŞ Hasan TOZ Girişimsel Kardiyak İşlemler Sırasında ECMO Kullanımı Yalçın DALGIÇ Ekstrakorporal CO2 Uzaklaştırılması (ECCO2r) Altay Nihat ACAR Ahmet ESKİOCAK

10.37609/akya.894

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Retrospective Evaluation of 85 Patients with Carotid Endarterectomy: Results of Different Techniques

e-Journal of Cardiovascular Medicine (2020)

Cihan Yücel Serkan Ketenciler Melek Yılmaz Nihan Kayalar

Objectives: Carotid endarterectomy (CEA) is a safe and effective surgical technique that prevents stroke in symptomatic and asymptomatic patients with severe internal carotid artery (ICA) stenosis.However, this surgical procedure is associated with a perioperative stroke risk of 2-7.5%.In this study, we examined the characteristics and early results of patients who underwent surgery for carotid artery stenosis in light of the current literature. Materials and Methods:We retrospectively evaluated the data of patients who were diagnosed with symptomatic and asymptomatic ICA stenosis between January 2019 and January 2020 and underwent CEA in our hospital.A total of 85 patients were included in the study. Results:The mean age of the patients was 67±8.2 years and 72.9% of the patients were male.The most common accompanying risk factors were smoking (64.7%) and hypertension (61.1%).Majority of patients had CEA for symptomatic carotid disease.One patient (1.1%) developed temporary hemiparesis.One patient (1.1%) developed transient ischemic attack.Six patients (7%) developed a postoperative hematoma and subsequently required revision.There was no mortality associated with the procedure. Conclusion:Carotid artery surgery is a reliable method with low mortality and morbidity rates especially in those centers with high numbers and experienced surgical teams.A team approach including anesthetists, neurologists and interventional radiologists or interventional vascular surgeons is the key to critical decision making and the success.

Endarterectomy

10.32596/ejcm.galenos.2020.05.026

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The effects of folic acid on vascular reactivity in a hyperhomocysteinemic rat model

DergiPark (Istanbul University) (2021)

Melek Yılmaz Hüseyin GEMALMAZ Cihan Yücel Serkan Ketenciler Uğur Gürcün

Reactivity

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A Rare Cause of Embolism: Cardiac Papillary Fibroelastoma