Ainaz Mihanfar

Urmia University of Medical Sciences

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Maryam Majidinia

Urmia University

Bahman Yousefi

Tabriz University of Medical Sciences

Mohammad Nouri

Tabriz University of Medical Sciences

Saber Ghazizadeh Darband

Urmia University of Medical Sciences

Mohammad Mirza‐Aghazadeh‐Attari

Johns Hopkins University

Shirin Sadighparvar

McGill University

Amir Fattahi

Tabriz University of Medical Sciences

Hamid Reza Nejabati

Tabriz University of Medical Sciences

Zeinab Latifi

Semnan University of Medical Sciences

Mojtaba Kaviani

Acadia University

Cooperative Institutions

Tabriz University of Medical Sciences

University of Tabriz

Urmia University

Urmia University of Medical Sciences

Biotechnology Research Center

Tehran University of Medical Sciences

Imam Reza Hospital

Sakarya University

Babol University of Medical Sciences

Shahid Beheshti University of Medical Sciences

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Serum Levels of Vaspin and Its Correlation with Nitric Oxide in Type 2 Diabetic Patients with Nephropathy

Current Diabetes Reviews (2017)

Ainaz Mihanfar Mohammad Rahmati‐Yamchi Ali Mota Sima Abediazar Younes Pilehvar‐Soltanahmadi

Background: Diabetic Nephropathy (DN), a serious and prevalent complication of diabetes, has been rapidly raising worldwide. Vaspin, as an adipokine with anti-diabetic effects, is predominantly released from visceral adipose tissue. Moreover, vaspin has the stimulatory effect on nitric oxide (NO) bioavailability through the activation of NO synthase. Objective: The aim of the present study was to investigate the serum levels of vaspin and their correlation with NO metabolite in diabetic patients with normal renal function and renal insufficiency. Methods: Volunteers patients with non-nephropathy Type 2 Diabetic Mellitus (T2DM) as control (n=40, age= 56.95±6.11 years) and patients with diabetic nephropathy (DN) (n=40, age=57.85±5.63 years) as case group were enrolled in this study, and serum samples were collected for the measurement of vaspin levels by ELISA technique. Also, serum levels of NO metabolites were calorimetrically assessed. Results: We found that vaspin levels significantly decreased in diabetic patients with nephropathic condition as compared with diabetic patients with normal renal function (p <0.04). In addition, serum levels of NO metabolites were significantly higher in diabetic patients with nephropathy in comparison with non-nephropathic diabetics (p<0.001). When patients with DN were studied, vaspin levels positively correlated with NO metabolites and Homeostasis model assessment of insulin resistance (HOMA-IR) levels. Conclusion: This study showed that low serum vaspin levels may be a risk factor for nephropathy in type II diabetic patients and increased levels of NO may be a defensive mechanism in the DN.

10.2174/1573399813666170530103216

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Association Between Matrix Metalloproteinase-3 Activity and Glomerular Filtration Rate and Albuminuria Status in Patients With Type 2 Diabetes Mellitus.

PubMed (2018)

Mina Amanzadeh Ali Mota Nosratollah Zarghami Sima Abediazar Sina Abroon

Diabetic nephropathy is pictured as matrix accumulation and thickening of glomerular basal membrane. Matrix metalloproteinases (MMPs) are major proteases involved in extracellular matrix degradation. Moreover, plasminogen activator inhibitor-1 (PAI-1) primarily regulates plasmin dependent proteolysis. It plays a role in renal fibrosis causing extracellular matrix accumulation through inhibition of plasmin-dependent extracellular matrix degradation. This study investigated PAI-1 serum level and MMP-3 activity and their correlation with glomerular filtration rate in patients with diabetes mellitus.In a case-control design, serum PAI-1 concentrations and MMP-3 activity were measured in 80 patients with normoalbuminuria, microalbuminuria, and macroalbuminuria. Receiver operating characteristics curve analysis was used to assess the diagnostic accuracy of MMP-3 activity in discriminating albuminuria.In the patients with microalbuminuria, serum PAI-1 levels were higher compared with macroalbuminuric patients (P < .001). The patients with macroalbuminuria exhibited a significantly lower MMP-3 activity than the patients with microalbuminuria and normoalbuminuria (P < .001). No significant correlation was found between serum MMP-3 activity and serum PAI-1 levels in those with normoalbuminuria, microalbuminuria, and macroalbuminuria. The MMP-3 activity had a strong positive correlation with estimated glomerular filtration (r = 0.853, P < .001).We found that there was a positive correlation between glomerular filtration rate and MMP-3 activity in diabetic patients. This concludes that MMP-3 may have a role in the pathogenesis of diabetic nephropathy progressions towards macroalbuminuria, and therefore, MMP-3 activity may be used in evaluating albuminuria status.

Microalbuminuria

Albuminuria

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Parasympathetic, but not sympathetic denervation, suppressed colorectal cancer progression

European Journal of Pharmacology (2021)

Shirin Sadighparvar Saber Ghazizadeh Darband Firouz Ghaderi Pakdel Ainaz Mihanfar Maryam Majidinia

Guanethidine

1,2-Dimethylhydrazine

10.1016/j.ejphar.2021.174626

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SIRT1: a promising therapeutic target in type 2 diabetes mellitus

Archives of Physiology and Biochemistry (2021)

Ainaz Mihanfar Maryam Akbarzadeh Saber Ghazizadeh Darband Shirin Sadighparvar Maryam Majidinia

A significant increase in the worldwide incidence and prevalence of type 2 diabetic mellitus (T2DM) has elevated the need for studies on novel and effective therapeutic strategies. Sirtuin 1 (SIRT1) is an NAD + dependent protein deacetylase with a critical function in the regulation of glucose/lipid metabolism, insulin resistance, inflammation, oxidative stress, and mitochondrial function. SIRT1 is also involved in the regulation of insulin secretion from pancreatic β-cells and protecting these cells from inflammation and oxidative stress-mediated tissue damages. In this regard, major SIRT1 activators have been demonstrated to exert a beneficial impact in reversing T2DM-related complications including cardiomyopathy, nephropathy, retinopathy, and neuropathy, hence treating T2DM. Therefore, an accumulating number of recent studies have investigated the efficacy of targeting SIRT1 as a therapeutic strategy in T2DM. In this review we aimed to discuss the current understanding of the physiological and biological roles of SIRT1, then its implication in the pathogenesis of T2DM, and the therapeutic potential of SIRT1 in combating T2DM.

Sirtuin 1

10.1080/13813455.2021.1956976

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Citations (19)

In vitro and in vivo anticancer effects of syringic acid on colorectal cancer: Possible mechanistic view

Chemico-Biological Interactions (2021)

Ainaz Mihanfar Saber Ghazizadeh Darband Shirin Sadighparvar Mojtaba Kaviani Mohammad Mirza‐Aghazadeh‐Attari

Syringic acid

10.1016/j.cbi.2020.109337

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Citations (46)

Melatonin‐mediated regulation of autophagy: Making sense of double‐edged sword in cancer

Journal of Cellular Physiology (2019)

Mohammad Mirza‐Aghazadeh‐Attari Amir Mohammadzadeh Ali Adib Saber Ghazizadeh Darband Shirin Sadighparvar

Much research has been conducted to discover novel techniques to reverse the process of tumorigenesis and, cure already stablished malignancies. One well-stablished approach has been the use of organic compounds and naturally found agents such as melatonin whose anticancer effects have been shown in multiple studies, signaling a unique opportunity regarding cancer prevention and treatment. Various agents use a variety of methods to exert their anticancer effects. Two of the most important of these methods are interfering with cell signaling pathways and changing cellular functions, such as autophagy, which is essential in maintaining cellular stability against multiple exogenous and endogenous sources of stress, and is a major tool to evade early cell death. In this study, the importance of melatonin and autophagy are discussed, and the effects of melatonin on autophagy, and its contribution in the process of tumorigenesis are then noted.

SWORD

10.1002/jcp.28435

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DNA damage response and repair in colorectal cancer: Defects, regulation and therapeutic implications

DNA repair (2018)

Mohammad Mirza‐Aghazadeh‐Attari Saber Ghazizadeh Darband Mojtaba Kaviani Ainaz Mihanfar Javad Aghazadeh Attari

10.1016/j.dnarep.2018.07.005

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Citations (64)

Crosstalk between miRNA and PI3K/AKT/mTOR signaling pathway in cancer

Life Sciences (2021)

Maryam Akbarzadeh Ainaz Mihanfar Shabnam Akbarzadeh Bahman Yousefi Maryam Majidinia

Crosstalk

RPTOR

10.1016/j.lfs.2021.119984

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Citations (80)

Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome

The Journal of Steroid Biochemistry and Molecular Biology (2021)

Ainaz Mihanfar Mohammad Nouri Leila Roshangar Mohammad Hassan Khadem Ansari

Fisetin

Aminoglutethimide

10.1016/j.jsbmb.2021.105954

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Doxorubicin loaded magnetism nanoparticles based on cyclodextrin dendritic-graphene oxide inhibited MCF-7 cell proliferation

BioMolecular Concepts (2021)

Ainaz Mihanfar Niloufar Targhazeh Shirin Sadighparvar Saber Ghazizadeh Darband Maryam Majidinia

Doxorubicin (DOX) is an effective chemotherapeutic agent used for the treatment of various types of cancer. However, its poor solubility, undesirable side effects, and short half-life have remained a challenge. We used a formulation based on graphene oxide as an anticancer drug delivery system for DOX in MCF-7 breast cancer cells, to address these issues. In vitro release studies confirmed that the synthesized formulation has an improved release profile in acidic conditions (similar to the tumor microenvironment). Further in vitro studies, including MTT, uptake, and apoptosis assays were performed. The toxic effects of the nanocarrier on the kidney, heart and liver of healthy rats were also evaluated. We observed that the DOX-loaded carrier improved the cytotoxic effect of DOX on the breast cell line compared to free DOX. In summary, our results introduce the DOX-loaded carrier as a potential platform for in vitro targeting of cancer cells and suggest further studies are necessary to investigate its in vivo anti-cancer potential.

MCF-7

Nanocarriers

MTT assay

Liver Cancer

10.1515/bmc-2021-0002

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Citations (19)