Gelson Perin

Universidade Federal de Pelotas

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Eder J. Lenardão

Universidade Federal de Pelotas

219

Raquel G. Jacob

Universidade Federal de Pelotas

166

Diego Alves

Universidade Federal de Pelotas

114

Márcio S. Silva

Universidade Federal de Pelotas

Angelita M. Barcellos

Universidade Federal do Rio Grande

Ricardo F. Schumacher

Universidade Federal de Santa Maria

Filipe Penteado

Universidade Federal de Santa Maria

Thiago J. Peglow

Universidade Federal Fluminense

Samuel Thurow

Universidade Federal de Pelotas

Cláudio C. Silveira

Universidade Federal de Santa Maria

Cooperative Institutions

Universidade Federal de Pelotas

197

Universidade Federal de Santa Maria

Universidade Federal do Rio Grande do Sul

Universidade de São Paulo

University of Perugia

Universidade Federal de Santa Catarina

Instituto de Ciências Farmacêuticas

Universidade Federal do Pampa

University of Florence

Universidade Federal de São Carlos

Author Statistics

Papers

Citation

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i-10 index

Research Field

Synthesis of vinyl sulfides via hydrothiolation of alkynes using Al2O3/KF under solvent-free conditions

Tetrahedron Letters (2008)

Márcio S. Silva Renata G. Lara Júnior M. Marczewski Raquel G. Jacob Eder J. Lenardão

Markovnikov's rule

10.1016/j.tetlet.2008.01.093

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Citations (47)

Bis-(3-amino-2-pyridine) diselenide improves psychiatric disorders –atopic dermatitis comorbidity by regulating inflammatory and oxidative status in mice

Chemico-Biological Interactions (2021)

Caren A.R. da Fonseca Angélica S. Reis Mikaela P. Pinz Thiago J. Peglow Ricardo F. Schumacher

Corticosterone

10.1016/j.cbi.2021.109564

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Citations (4)

Cover Feature: Visible Light‐Triggered Radical Annulation of ortho‐Thioaryl Ynones: A General Approach to Prepare 3‐Sulfenylthiochromones (ChemCatChem 7/2023)

ChemCatChem (2023)

Ricardo H. Bartz Krigor B. Silva Rafaela R. S. A. Santos Thiago J. Peglow Eder J. Lenardão

Graphical Abstract The Cover Feature shows the office environment of an organic synthesis laboratory, centered around a “synthetic tools desk,” which is a place where ideas are discussed on a daily basis. In their Research Article, R. H. Bartz et al. demonstrated one of the few cases in which an intramolecular EDA-complex (the molecule on the desk) is used as a species that can absorb blue light (440 nm) and trigger an annulative radical process. In this sophisticated synthetic transformation, thiols are used as reactants, giving rise to the “most wanted” 3-sulfenylthiochromones. This strategy circumvents the classical use of photocatalytic species in light-mediated reactions, as well as the use of oxidants and heating, readily yielding the desired products in a short reaction time. Taken together, the main features of the developed approach meet some principles of green chemistry and promote sustainable chemistry. More information can be found in the Research Article by R. H. Bartz et al..

Annulation

Feature (linguistics)

10.1002/cctc.202300377

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Citations (0)

ChemInform Abstract: Direct Michael Addition to Electron‐Deficient Alkenes Using Diorganyl Dichalcogenides (Te/S) and NaBH₄/PEG‐400.

ChemInform (2015)

Gelson Perin Elton L. Borges Thiago J. Peglow Eder J. Lenardão

10.1002/chin.201511262

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Citations (0)

Metal and base-free synthesis of arylselanyl anilines using glycerol as a solvent

Green Chemistry (2014)

Samuel Thurow Filipe Penteado Gelson Perin Raquel G. Jacob Diego Alves

We describe here a metal and base-free straightforward method to access arylselanyl anilines using glycerol as a solvent. Starting from N,N-disubstituted anilines and arylselanyl chloride, the protocol is general and was successfully applied to a sort of anilines with different substitution patterns in both the aromatic ring and the nitrogen atom. As desirable for a green synthetic procedure, the non-toxic, low volatile, renewable glycerol was used as a solvent at room temperature.

Base (topology)

Nitrogen atom

Free base

10.1039/c4gc00874j

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Citations (50)

NMR chiral discrimination of chalcogen containing secondary alcohols

Chirality (2018)

Naiade B.G. Marques Raquel G. Jacob Gelson Perin Eder J. Lenardão Diego Alves

Abstract Here, we report the general strategies by which NMR spectroscopy can be used to determine the enantiopurity and absolute configuration of chalcogen containing secondary alcohols, including the evaluation of the use of chiral solvating and chiral derivatizing agents. The BINOL/DMAP ternary complex demonstrated a simple and fast protocol for determining enantiopurity. The drug Naproxen afforded a stable, nonhygroscopic, and readily available chiral derivatizing agent (CDA) for NMR chiral discrimination of chalcogen containing secondary alcohols. The chiral recognition by CDA and chiral solvating agent (CSA) was assessed using 1 H, 77 Se‐{1H}, and 125 Te‐{1H} NMR spectroscopy. A simple model for the assignment of the absolute configuration from NMR data is presented.

Chalcogen

Absolute Configuration

Chiral derivatizing agent

Proton NMR

10.1002/chir.23030

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Citations (9)

Quinolines-1,2,3-triazolylcarboxamides exhibits antiparasitic activity in Trichomonas vaginalis

Biotechnology Research and Innovation (2019)

Ângela Sena-Lopes Raquel Nascimento das Neves Mirna Samara Dié Alves Gelson Perin Diego Alves

Increased prevalence of metronidazole-resistant infections has resulted in a search for alternative drugs for the treatment of trichomoniasis. In the present study, we report the evaluation of in vitro activity of three quinolines-1,2,3-triazolylcarboxamides (QTCA-1, QTCA-2 and QTCA-3) against Trichomonas vaginalis, evaluation of cytotoxicity in CHO cells and expression of genes related to hydrogenosome by real time PCR. Nine concentrations of these compounds were analyzed for in vitro activity against ATCC 30236 isolate of T. vaginalis. QTCA-2 reported a cytotoxic effect against 100% of T. vaginalis trophozoites at a final concentration of 80 μM with an IC50 of 50 μM. The kinetic growth curve of trophozoites indicated that QTCA-2 reduced the growth by 70% at a concentration of 80 μM after an exposure of 12 h, and induced complete parasite death at 24 h. QTCA-2 induced less than 30% of cytotoxicity in CHO-K1 cells at 80 μM and data showed this concentration and lower ones had no significant cytotoxic effect when compared to the control. There was no significant difference in gene expression (pyruvate-ferredoxin oxidoreductase A and B; Malic enzyme D; Hydrogenase; β-tubulin) when compared to control and MTZ. Further in silico analysis showed that QTCA-2 had significant binding free energy with T. vaginalis lactate dehydrogenase (−9.3 kcal/mol), purine nucleoside phosphorylase (−9.1 kcal/mol) and triosephosphate isomerase (−7.3 kcal/mol). The present study offers new perspectives for exploring the potential of this class of molecules as an additional option for the treatment of trichomoniasis.

Antiparasitic

Trichomonas

Antiparasitic agent

10.1016/j.biori.2019.06.003

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Citations (1)

Synthesis of 2‐Organylchalcogenopheno[2,3‐b]pyridines from Elemental Chalcogen and NaBH₄/PEG‐400 as a Reducing System: Antioxidant and Antinociceptive Properties

ChemMedChem (2020)

Thiago J. Peglow Ricardo H. Bartz Carolina C. Martins Andrei L. Belladona Cristiane Luchese

Abstract An alternative method to prepare 2‐organylchalcogenopheno[2,3‐ b ]pyridines was developed by the insertion of chalcogen species (selenium, sulfur or tellurium), generated in situ , into 2‐chloro‐3‐(organylethynyl)pyridines by using the NaBH 4 /PEG‐400 reducing system, followed by an intramolecular cyclization. It was possible to obtain a series of compounds with up to 93 % yield in short reaction times. Among the synthesized products, 2‐organyltelluropheno[2,3‐ b ]pyridines have not been described in the literature so far. Moreover, the compounds 2‐phenylthieno[2,3‐ b ]pyridine ( 3 b ) and 2‐phenyltelluropheno[2,3‐ b ]pyridine ( 3 c ) exhibited significant antioxidant potential in different in vitro assays. Further studies demonstrated that compound 3 b exerted an antinociceptive effect in acute inflammatory and non‐inflammatory pain models, thus indicating the involvement of the central and peripheral nervous systems on its pharmacological action. More specifically, our results suggest that the intrinsic antioxidant property of compound 3 b might contribute to attenuating the nociception and inflammatory process on local injury induced by complete Freund's adjuvant (CFA).

Chalcogen

Anti-inflammatory

10.1002/cmdc.202000358

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Citations (4)

CCDC 2054144: Experimental Crystal Structure Determination

The Cambridge Structural Database (2021)

Thiago J. Peglow Ricardo H. Bartz Thiago Barcellos Ricardo F. Schumacher Roberta Cargnelutti

10.5517/ccdc.csd.cc26yhqd

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Citations (0)

ChemInform Abstract: Catalyst‐Free Synthesis of Benzodiazepines and Benzimidazoles Using Glycerol as Recyclable Solvent.

ChemInform (2011)

Cátia S. Radatz Rodrigo B. Silva Gelson Perin Eder J. Lenardão Raquel G. Jacob

10.1002/chin.201147169

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Citations (1)