Elizabeth Castro Moreno

Fundação Centro de Hematologia e Hemoterapia de Minas Gerais

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ÉC

Éster Cerdeira Sabino

Universidade de São Paulo

José Roberto Lambertucci

Universidade Federal de Minas Gerais

Thelma T. Gonçalez

Vitalant

Eduarda Bolina‐Santos

Universidade Federal de Minas Gerais

Maria Norma Melo

Universidade Federal de Minas Gerais

Brian Custer

Vitalant

Mariângela Carneiro

Universidade Federal de Minas Gerais

Carolina Miranda

Hospital Samaritano de São Paulo

Roberta Bruhn

Pacific Research Institute

Antero Silva Ribeiro de Andrade

Centro de Desenvolvimento da Tecnologia Nuclear

Cooperative Institutions

Universidade Federal de Minas Gerais

Fundação Oswaldo Cruz

Fundação Centro de Hematologia e Hemoterapia de Minas Gerais

Universidade de São Paulo

National Institutes of Health

Centre National de la Recherche Scientifique

Universidade Federal de Ouro Preto

Johns Hopkins University

University of California, San Francisco

Institut de Recherche pour le Développement

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Vigilância epidemiológica no Programa de Controle da Doença de Chagas em Minas Gerais, Brasil (1984-1998)

Cadernos de Saúde Pública (2000)

Elizabeth Castro Moreno Lúcia Baracho

É apresentada a metodologia utilizada em Minas Gerais para a vigilância no Programa de Controle da Doença de Chagas. O sistema é desenvolvido com a participação das comunidades, desde o planejamento à tomada de decisões e deve ser gradativamente assumido pelos municípios no processo de municipalização das ações e serviços de saúde do Sistema Único de Saúde (SUS).

Epidemiological surveillance

Chagas Disease

10.1590/s0102-311x2000000800015

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Citations (16)

Monitoring the evolution of antigen-specific antibodies in circulation and their corresponding B cell clones in longitudinal immunization case studies through the use of NG-XMT (P4186)

The Journal of Immunology (2013)

Jaime Darce Stephen Lutz Sandra M Schieferl Elizabeth Castro Moreno Ravi Ramenani

Abstract Previous studies aimed at determining the affinity maturation pathways of monoclonal antibodies during an immunization have relied on comparing germ-line with mature forms of antibodies present in either transgenic B cell receptor mouse models or by cloning circulating human B cells present in peripheral blood (PB) of pre and post-immunized individuals. These approaches have been insightful, but they do not identify in confidence the true B cell clone(s) producing the antigen-specific antibodies found in the sera of immunized animals or humans. We recently developed a technology, NG-XMTTM, encompassing tandem mass spectrometry and next generation sequencing1,2, which for the first time enables the 1) identification of the anatomical location of the B cell clone(s) corresponding to the antigen-specific serum antibodies 2) investigation of clonal diversity of antigen-specific B cell clones residing in primary and secondary lymphoid organs and circulating in PB and 3) analysis of the evolving affinity mature serum antibodies, in two longitudinal immunization studies of rabbits and humans. These results not only advance our understanding of the affinity maturation process and the dynamics of memory B cells and plasma cell development that occurs during an immunization response, they also allow us to use this information to generate useful recombinant antibodies that can be utilized in passive immunization strategies. 1Nat Biotechnol. 2012,30:447; 2Nat Biotechnol. 2012,30:1039

clone (Java method)

10.4049/jimmunol.190.supp.48.3

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Knowledge of HIV testing and attitudes towards blood donation at three blood centres in Brazil

Vox Sanguinis (2013)

Carolina Miranda Elizabeth Castro Moreno Roberta Bruhn Nina Larsen David J. Wright

Reducing risk of HIV window period transmission requires understanding of donor knowledge and attitudes related to HIV and risk factors.We conducted a survey of 7635 presenting blood donors at three Brazilian blood centres from 15 October through 20 November 2009. Participants completed a questionnaire on HIV knowledge and attitudes about blood donation. Six questions about blood testing and HIV were evaluated using maximum likelihood chi-square and logistic regression. Test seeking was classified in non-overlapping categories according to answers to one direct and two indirect questions.Overall, respondents were male (64%) repeat donors (67%) between 18 and 49 years old (91%). Nearly 60% believed blood centres use better HIV tests than other places; however, 42% were unaware of the HIV window period. Approximately 50% believed it was appropriate to donate to be tested for HIV, but 67% said it was not acceptable to donate with risk factors even if blood is tested. Logistic regression found that less education, Hemope-Recife blood centre, replacement, potential and self-disclosed test-seeking were associated with less HIV knowledge.HIV knowledge related to blood safety remains low among Brazilian blood donors. A subset finds it appropriate to be tested at blood centres and may be unaware of the HIV window period. These donations may impose a significant risk to the safety of the blood supply. Decreasing test-seeking and changing beliefs about the appropriateness of individuals with behavioural risk factors donating blood could reduce the risk of transfusing an infectious unit.

Window period

Hiv test

Blood donations

Blood test

Blood testing

10.1111/vox.12114

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Test seeking: are healthcare professionals referring people to blood centers for infections marker testing?

Hematology Transfusion and Cell Therapy (2019)

Elizabeth Castro Moreno Roberta Bruhn Éster Cerdeira Sabino Eduarda Bolina‐Santos Carolina Miranda

Test-seeking is associated with HIV in Brazilian blood donors. This study sought to investigate the frequency with which three different donor groups: deferred donors, accepted donors who tested HIV positive [HIV (+)], and accepted donors who tested infectious disease markers negative [IDM (-)], came to the blood bank at the suggestion of a health care professional.Donors deferred for reporting high-risk behaviors and participants in an HIV risk factor case-control study completed a confidential audio computer-assisted self-interview (ACASI) that included two questions related to health care professionals and test-seeking.Of 4013 enrolled deferred donors, 468 (11.8%) reported a health care professional suggested donation as a way to be tested for infection. Of 341 HIV (+) and 791 IDM (-) participants, 43 (12.6%) and 11 (1.4%), respectively, reported a health care professional suggested donation as a way to be tested for infection. Physicians were the most frequently reported source of referral: [(61.5% of deferred, 69.1% of HIV (+), and 9.1% of IDM (-) donors)].HIV (+) donors and deferred donors were 10 times more likely to report test-seeking behavior by suggestion of health care professional than IDM (-) donors. If true, efforts should be made to educate health care professionals and blood donors on how to safeguard the blood supply, emphasizing that HIV testing should be done at volunteer testing centers rather than at the blood centers.

Health Professionals

Blood test

10.1016/j.htct.2018.11.002

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Citations (6)

Blood donation in a large urban centre of southeast Brazil: a population‐based study

Transfusion Medicine (2016)

Elizabeth Castro Moreno Eduarda Bolina‐Santos Franciane Mendes-Oliveira Carolina Miranda Éster Cerdeira Sabino

This study aimed to estimate the prevalence and characterise potential blood donors and non-donors in a well-populated and representative urban area of Southeastern Brazil.Studies on blood donation usually evaluate individuals who donate. Population-based studies may contribute to characterise those who never reach the blood centre, trying to increase the range of donors.This was a secondary analysis of a population-based survey and a blood donor motivation study [Recipient Epidemiology and Donor Evaluation study (REDS II) International]. In a cross-sectional study 4047 individuals representing a metropolitan area answered the question 'Have you ever donated blood at least once in your life?'. The profiles ('Yes/No') were compared. Non-donors from this reference population were compared with donors of a local blood center, in a case control analysis.A total of 69·0% of the population had never donated blood and was composed mostly of women, younger than 30 years old, people not contributing to social security and not subscribing to newspapers. In the case-control study, the likelihood of donating was higher for: men, younger than 50 years old, longer time of education, married, participating in political campaigns and with a good self-perception of health. The factors associated with no blood donation were: self-reported mixed or white race/ethnicity, income higher than two minimum wages and belonging to trade union, political, religious/spiritual, or other social group and worse self perception of health.This population-based study allowed us to characterise a high proportion of people that never reaches the blood centre. The results may be used to diversify the donor profile, creating strategies to target those least likely to donate blood, as women, white people and those with higher income and purchasing power.

10.1111/tme.12285

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Citations (13)

Corrigendum to: “Assessing the risk of releasing transgenic Cucurbita spp. in Mexico” [Agric. Ecosyst. Environ. 112 (2006) 291–299]

Agriculture Ecosystems & Environment (2006)

Laura Arriaga Elleli Huerta Rafael Lira‐Saade Elizabeth Castro Moreno Jesús Alarcón

10.1016/j.agee.2006.02.001

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Citations (3)

Propuesta para el mejoramiento del sistema de mensajería en la Corporación Financiera Colombiana

instname:Universidad Piloto de Colombia (2008)

Elizabeth Castro Moreno Edith Andrea Sepúlveda Díaz

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Neutralizing antibodies associated with exposure factors to Orthopoxvirus in laboratory workers

Vaccine (2013)

Galileu Barbosa Costa Elizabeth Castro Moreno Giliane de Souza Trindade

Extensive use of Vaccinia virus (VACV) in research has led to associated accidental human exposure in laboratories worldwide. In spite of the social and economic relevance of Bovine Vaccinia outbreaks in Brazil, national data concerning laboratory workers handling these infectious agents are relatively scarce. Therefore, a serological survey was conducted in a Brazilian laboratory to evaluate staff exposure to orthopoxviruses (OPVs). Information concerning direct work with OPVs, vaccination status and laboratory accidents was collected and correlated to serology results. This study presents an opportunity for discussion of routine procedures involving OPVs in laboratories and their intrinsic risks. Aspects of the live attenuated smallpox vaccine are also discussed.

Orthopoxvirus

Monkeypox

Smallpox vaccine

Variola virus

10.1016/j.vaccine.2013.08.023

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Citations (7)

Assessing the risk of releasing transgenic Cucurbita spp. in Mexico

Agriculture Ecosystems & Environment (2005)

Laura Arriaga Elleli Huerta Rafael Lira‐Saade Elizabeth Castro Moreno Jesús Alarcón

Cucurbita

Cucurbita pepo

Cucurbita moschata

Squash

10.1016/j.agee.2005.07.007

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Citations (24)

Association between inflammatory molecules, nitric oxide metabolites and leg ulcers in individuals with sickle cell anemia

Hematology Transfusion and Cell Therapy (2020)

André Rolim Belisário Franciane Mendes-Oliveira Valquíria Reis de Souza Eduarda Bolina‐Santos Fabíola Gomes Mendes

Leg ulcers (LUs) are relatively common in patients with sickle cell anemia (SCA). The role of inflammation and nitric oxide (NO) pathways in the pathophysiology of the LU is not understood.The aim of this study was to verify the association between inflammatory molecules and nitric oxide metabolites (NOx) and the occurrence of the LU in patients with SCA.It was a cross-sectional study on adult participants with SCA followed at Fundação Hemominas, a public blood center in Brazil. Eligible participants were recruited and included in one of two groups: Group 1, comprised of cases with SCA (Hb SS) and at least one LU at the time of inclusion in the study and Group 2, comprised of controls with SCA without a history of LU, matched by sex and age to cases. Participants were interviewed to obtain sociodemographic data and blood samples were collected. Clinical and laboratory data were abstracted from medical records. Nitric oxide metabolites (NOx) and inflammatory molecules were quantified using an immunoassay and Multiplex xMAP® technology, respectively. Eighty-seven individuals were included, ranging in age from 17 to 61 years (mean 40 ± 10.7 years); 30 had LU and 57 were controls without LU.Participants with LU had significantly higher levels of interleukin 8 (IL-8), IL-10, IL-15, NOx and platelet and white blood cell (WBC) counts, when compared to those without LU. Participants with LU had a significantly higher risk of having a history of osteomyelitis and a higher use of antiseptic soap in bathing, when compared to those without LU.In conclusion, our results showed that NOx, inflammatory molecules and hematological features were associated with LU in Brazilian adults with SCA.

Leg ulcer

10.1016/j.htct.2020.09.152

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Citations (5)