Huai‐Yi Chen

Huafan University

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Chiung-Hui Lai

Chung Hua University

S. Chao

National Tsing Hua University

Ji‐Yen Cheng

National Yang Ming Chiao Tung University

Allen Jong-Woei Whang

National Taiwan University of Science and Technology

Shi-Chi Chen

National Taiwan University of Science and Technology

Shu-Hua Yang

National Taiwan University of Science and Technology

Yi‐Yung Chen

Mackay Memorial Hospital

Horng‐Show Koo

Minghsin University of Science and Technology

Chu-Feng Chen

National Yang Ming Chiao Tung University

Yi-Lung Lai

National Taiwan University of Science and Technology

Cooperative Institutions

National Yang Ming Chiao Tung University

National Tsing Hua University

National Taiwan University

Academia Sinica

Huafan University

National Taiwan University of Science and Technology

Research Center for Applied Science, Academia Sinica

Industrial Technology Research Institute

National Taiwan Ocean University

Chang Gung University

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Counter Electrodes Prepared by Few Layer and Multilayer Graphene Mixed with Molybdenum Disulfide for Platinum-Free Dye-Sensitized Solar Cells

The Japan Society of Applied Physics (2016)

Yu-Chen Chou Huai‐Yi Chen

Molybdenum disulfide

Auxiliary electrode

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Doxycycline inhibits electric field-induced migration of non-small cell lung cancer (NSCLC) cells

Scientific Reports (2019)

Hui‐Fang Chang Hung-Tien Cheng Huai‐Yi Chen Wing Kiu Yeung Ji‐Yen Cheng

Abstract Adenocarcinoma, large cell carcinoma and squamous cell carcinoma are the most commonly diagnosed subtypes of non-small cell lung cancers (NSCLC). Numerous lung cancer cell types have exhibited electrotaxis under direct current electric fields (dcEF). Physiological electric fields (EF) play key roles in cancer cell migration. In this study, we investigated electrotaxis of NSCLC cells, including human large cell lung carcinoma NCI-H460 and human lung squamous cell carcinoma NCI-H520 cells. Non-cancerous MRC-5 lung fibroblasts were included as a control. After dcEF stimulation, NCI-H460 and NCI-H520 cells, which both exhibit epithelial-like morphology, migrated towards the cathode, while MRC-5 cells, which have fibroblast-like morphology, migrated towards the anode. The effect of doxycycline, a common antibiotic, on electrotaxis of MRC-5, NCI-H460 and NCI-H520 cells was examined. Doxycycline enhanced the tested cells’ motility but inhibited electrotaxis in the NSCLC cells without inhibiting non-cancerous MRC-5 cells. Based on our finding, further in-vivo studies could be devised to investigate the metastasis inhibition effect of doxycycline in an organism level.

Cell type

10.1038/s41598-019-44505-8

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Citations (14)

Influence of hydroxyl content on second-order nonlinearity in thermally poled type-III fused silica

Optics Communications (2009)

Huai‐Yi Chen Ching-Li Chang Hung‐Yi Lin

Poling

Intensity

Content (measure theory)

10.1016/j.optcom.2009.01.031

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Citations (1)

Creation of second-order nonlinearity and quasi-phase-matched second-harmonic generation in Ge-implanted fused silica planar waveguide

Applied Physics Letters (2005)

Huai‐Yi Chen Chun-Lin Lin Yu-Hsien Yang S. Chao Huan Niu

A planar waveguide was formed in fused silica plate by implantation of 5-MeV Ge2+ ions to a dose of 1015ions∕cm2. Thermal poling created larger second-order nonlinearity in the waveguide than in blank fused silica plate. The nonlinearity could be erased by 266nm ultraviolet exposure. Periodical nonlinearity distribution in the waveguide was implemented by periodical UV exposure. The first-order quasi-phase-matched second-harmonic generation from 1064nm fundamental mode to 532nm fundamental mode was achieved in the waveguide. The d33:d31 ratio was found to be 3.2:1, in favor of the built-in electric field model for Ge-implanted silica waveguide.

Waveguide

Poling

10.1063/1.1871343

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Citations (15)

Crack-free Microfabrication of Glass Ceramic Using Visible LIBWE

Ji‐Yen Cheng Huai‐Yi Chen Mansoureh Seyedehmansoureh Zarei Mousavi Chia-Hao Chang Chou-Yuan-Yuan Chang

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Effects of low-temperature Si buffer thickness and SiGe oxidation on sensitivity of Si

Japanese Journal of Applied Physics (2015)

Yi-Lung Lai Tai-Yuan Chang Kow‐Ming Chang Chu-Feng Chen Chiung-Hui Lai

Buffer (optical fiber)

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Mathematical analysis of the static solar concentrator with cascading right-angle prisms

WIT transactions on information and communication technologies (2014)

Allen Jong-Woei Whang Yi-Lung Lai Shu-Hua Yang Chiung-Hui Lai Huai‐Yi Chen

Concentrator

Prism

10.2495/cccs130181

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Second-Order Optical Nonlinearity Induced in Thermally Poled PbO–SiO₂ Mixed Film on Fused Silica

Japanese Journal of Applied Physics (2008)

Huai‐Yi Chen Hung‐Yi Lin

We developed a lead oxide PbO film of ∼170 nm thickness by RF sputtering on a fused silica substrate. When this film sample is annealed in an oven at 650 °C for 4 min, its physical thickness measured using a surface profiler decreases to ∼163 nm, but its optical film thickness determined using a spectrophotometer increases to 382 nm. This fact implies that PbO will diffuse into the fused silica substrate and form a PbO–SiO2 mixed film that is a graded-index planar waveguide with two transverse electric (TE) modes at 633 nm wavelength. Although the Maker fringe patterns of both fused silica and PbO–SiO2 mixed film samples thermally poled at 6 kV, 275 °C and 30 min look similar, we speculate that second-order nonlinearity exists in poled PbO–SiO2 mixed film because of the higher refractive index contrast at the air-to-film interface. A nonlinear optical coefficient of approximately 1 pm/V in poled PbO–SiO2 mixed film is calculated using a double-step nonlinear profile and grid search fitting technique. The induced second-order nonlinearity is stable for at least several months.

10.1143/jjap.47.7140

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Citations (2)

Characterization of dye-sensitized solar cells based on various CaCO3-doped ZnO photoanodes prepared using wet powder mixing and grinding

Optik (2020)

Huai‐Yi Chen Bo-Yao Huang Horng‐Show Koo Mao-Ting Huang

Photocurrent

10.1016/j.ijleo.2020.164899

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Citations (9)

Influence of multi-energy boron difluoride implantation on the second-harmonic generation of thermally poled fused silica

Optical Materials (2020)

Huai‐Yi Chen Yang-Sheng Lin

Difluoride

10.1016/j.optmat.2020.110451

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Citations (3)