Toru KITA

Kyoto University

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Effects of ammonia on the gastric mucosal barrier in rats and dogs.

The Japanese Journal of Pharmacology (1989)

Masao Seiki Motonobu Murakami Jung Keun YOO Sanae TERANUMA Hiroshi Saita

10.1254/jjp.51.143

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Citations (7)

Cytoprotective Effect of Plasmin Inhibitor on Necrotizing Agent-Induced Gastric Lesions in Rats

The Japanese Journal of Pharmacology (1989)

Motonobu Murakami Jung Keun YOO Sanae Teramura Masami Inada Hiroshi Saita

We studied the effect of plasmin inhibitor on ethanol and ammonia-induced gastric mucosal lesions in rats using an ex vivo chamber. Tranexamic acid and aminocaproic acid significantly inhibited macroscopic gastric hemorrhagic necrosis and attenuated the decrease of gastric transmucosal potential difference induced by 50% ethanol and 1% ammonia. The protection of gastric mucosa afforded by tranexamic acid and aminocaproic acid was not affected by pretreatment with indomethacin (5 mg/kg). These results suggest that plasmin inhibitor plays an important role in the prevention of gastric deep necrosis following exposure of the stomach to a damaging agent.

Aminocaproic acid

Antifibrinolytic

10.1016/s0021-5198(19)42488-8

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Effects of Ammonia on the Gastric Mucosal Barrier in Rats and Dogs

The Japanese Journal of Pharmacology (1989)

Masao SEIKl Motonobu Murakami Jung Keun YOO Sanae TERANUMA Hiroshi Saita

Abstract—We examined the effect of ammonia on the gastric mucosal barrier by measuring the changes in transmucosal fluxes of H+, Na+ and K+. In rats, ammonia at concentrations of 0.1 to 0.5% increased the H+ loss from the lumen and 0.2 to 0.5% concentrations of ammonia increased both Na+ and K+ influxes into the lumen In dogs, in an exactly similar manner to rats, ammonia at concentrations of 0.1 to 0.5% increased H* loss, and ammonia at concentration of 0.5% increased both Na+ and K+ influxes into the lumen These results suggest that ammonia breaks the gastric mucosal barrier

Lumen (anatomy)

10.1016/s0021-5198(19)40150-9

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Cytoprotective effect of plasmin inhibitor on necrotizing agent-induced gastric lesions in rats.

The Japanese Journal of Pharmacology (1989)

Motonobu Murakami Jung Keun YOO Sanae Teramura Masami Inada Hiroshi Saita

Aminocaproic acid

Antifibrinolytic

10.1254/jjp.50.72

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Citations (2)