Kiavash Hushmandi

Baqiyatallah University of Medical Sciences

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Ali Zarrabi

Yuan Ze University

Milad Ashrafizadeh

Shandong First Medical University

Sepideh Mirzaei

Islamic Azad University, Science and Research Branch

Mehrdad Hashemi

Islamic Azad University Medical Branch of Tehran

Amirhossein Zabolian

Shahid Beheshti University of Medical Sciences

Salman Daneshi

University of Jiroft

Rasoul Raesi

Torbat Heydarieh University of Medical Sciences

Maliheh Entezari

Islamic Azad University Medical Branch of Tehran

Farid Hashemi

University of Tehran

Alan Prem Kumar

National University of Singapore

Cooperative Institutions

Institute for Health Metrics and Evaluation

1,736

University of Washington

1,640

Tehran University of Medical Sciences

407

University of Sydney

291

University of Electronic Science and Technology of China

268

Institute for Musculoskeletal Health

209

University College London

196

Veterans Health Administration

158

Royal North Shore Hospital

149

Islamic Azad University Medical Branch of Tehran

127

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Epigenetic regulation of temozolomide resistance in human cancers with an emphasis on brain tumors: Function of non-coding RNAs

Biomedicine & Pharmacotherapy (2023)

Aryan Rezaee Pooya M. Tehrany Farimah Jafari Tirabadi Negin Sanadgol Asal Sadat Karimi

Brain tumors, which are highly malignant, pose a significant threat to health and often result in substantial rates of mortality and morbidity worldwide. The brain cancer therapy has been challenging due to obstacles such as the BBB, which hinders effective delivery of therapeutic agents. Additionally, the emergence of drug resistance further complicates the management of brain tumors. TMZ is utilized in brain cancer removal, but resistance is a drawback. ncRNAs are implicated in various diseases, and their involvement in the cancer is particularly noteworthy. The focus of the current manuscript is to explore the involvement of ncRNAs in controlling drug resistance, specifically in the context of resistance to the chemotherapy drug TMZ. The review emphasizes the function of ncRNAs, particularly miRNAs, in modulating the growth and invasion of brain tumors, which significantly influences their response to TMZ treatment. Through their interactions with various molecular pathways, miRNAs are modulators of TMZ response. Similarly, lncRNAs also associate with molecular pathways and miRNAs, affecting the efficacy of TMZ chemotherapy. Given their functional properties, lncRNAs can either induce or suppress TMZ resistance in brain tumors. Furthermore, circRNAs, which are cancer controllers, regulate miRNAs by acting as sponges, thereby impacting the response to TMZ chemotherapy. The review explores the correlation between ncRNAs and TMZ chemotherapy, shedding light on the underlying molecular pathways involved in this process.

Temozolomide

Brain tumor

Brain cancer

10.1016/j.biopha.2023.115187

Cite

Citations (8)

Investigating the Relationship between the Position of Married People in the Levels of Maslow's Hierarchy of Needs, with Life Expectancy and the Desire to have Children

The Open Public Health Journal (2024)

Yeganeh Rahmanpour Leila Mohammadnahal Kiavash Hushmandi Seyed Hassan Saadat Sara Orouei

Background The difference in life expectancy and willingness to have children among married people is influenced by the different positions of people in the levels of Maslow's hierarchy of needs. Aim The current research was conducted to determine the relationship between the position of married people in the levels of Maslow's hierarchy of needs with their life expectancy and desire to have children. Methods This cross-sectional study was conducted using convenience sampling on 140 married people in the general population of Khaf City in 2022. Data were collected using an electronic questionnaire and analyzed using the SPSS-22 statistical software, Pearson correlation coefficient, and multiple regression statistical tests at a significance level of 0.05. Results The highest average score of Maslow's Hierarchy of needs was related to the level of basic needs (5.45±4.85), and the lowest average was related to the level of self-actualization needs (2.09±5.55). The average score of life expectancy and willingness to have children in the studied subjects was 25.41±6.62 (moderate) and 18.38±6.38 (low), respectively. There was a positive and significant correlation between the levels of Maslow's hierarchy of needs on life expectancy and the desire to have children in the studied subjects (p<0.001). Conclusion Basic needs are the most important needs of couples and they can directly affect life expectancy and the desire to have children. Therefore, the basic needs must be prioritized in the country's plans so that after the basic needs are met, conditions are created to improve life expectancy and the desire to have children.

10.2174/0118749445307861240606070850

Cite

Citations (0)

Risk of increased expression of ACE2 membrane protein in patients with hypertension: Review of COVID-19

Mehdi Pooladi Kiavash Hushmandi Maliheh Entezari

Context: In late 2019, COVID-19 launched a pandemic from around Wuhan, China. It`s called the SARS-CoV-2 virus which belongs to the corona family and it has a lot in common with SARS-CoV-2, but it has been reported to be more common. Evidence Acquisition: The risk of the virus is high for people with high blood pressure and use medication. The reason for this potential and risk for COVID-19 is an increase in expression in a membrane protein called ACE2. This protein is responsible for converting Ang I to Ang1-9 as well as converting Ang II to Ang1-7. Results: Its pathogenic role is due to its receptor for SARS-CoV-2 and SARS-CoV. Research has shown that there is a significant link between hypertension, Increase the expression and activity of ACE2 and having coronavirus. That`s why our goal is to remind people of high blood pressure about the risk of developing Covid-19. We studied ACE2 and Covid-19 from a clinical and biological point of view. In the following we have shown the position and the type of virus connection to ACE2 with the help of protein database. Conclusion: In the SARS-Cov-2, there are four structural proteins and several non-structural proteins together with capsid can contain positive-stranded RNA viruses. Studies have shown that the Spike (S) protein binds strongly to the chain E and F with the ACE2 receptor.

Angiotensin-converting enzyme 2

Pandemic

Coronavirus

10.22037/aab.v12i1.30521

Cite

Citations (0)

Biomedical application of chitosan-based nanoscale delivery systems: Potential usefulness in siRNA delivery for cancer therapy

Carbohydrate Polymers (2021)

Milad Ashrafizadeh Masoud Delfi Farid Hashemi Amirhossein Zabolian Hossein Saleki

Biocompatibility

Cancer Therapy

10.1016/j.carbpol.2021.117809

Cite

Citations (131)

Association between Serum Electrolyte Levels and Consciousness in ICU Patients: A Cross-Sectional Study

The Open Public Health Journal (2024)

Ehsan Goroohi Sardu Akbar Anaeigoudari Asma Amiri Domari Rasoul Raesi Kiavash Hushmandi

Background A change in fluid and electrolyte balance is a dynamic process that can cause a wide range of clinical disorders. Aim The present study was conducted to determine the serum level of electrolytes and their relationship with the level of consciousness. Methods This cross-sectional (descriptive-analytical) study was conducted using a census method on 110 medical records of patients admitted to the ICU department of Imam Khomeini Hospital in Jiroft in 2021. Data were collected using a researcher-made checklist from the patient’s medical records and analyzed using SPSS-20 statistical software and descriptive and inferential tests at a significance level of p<0.05. Results The average age of the patients was 31.8 ± 18.8 years. Eighty-two patients (74.5%) were men who were hospitalized due to a motorcycle accident. No significant relationship was found between serum phosphorus levels, hospital stay duration, and mortality rate. There was a significant relationship between magnesium serum level and mortality rate, but there was no relationship between serum potassium and magnesium, the duration of hospitalization, and the average days of hospitalization. Conclusion The results showed that there is no significant relationship between the average serum level of electrolytes and the level of consciousness. It is possible that factors other than electrolytes, such as the status of arterial gases, the need for advanced airway care, medicinal agents, and other therapeutic interventions, may influence the level of consciousness.

Cross-sectional study

Association (psychology)

10.2174/0118749445305097240521114548

Cite

Citations (0)

Crosstalk of Long Non-coding RNAs and EMT: Searching the Missing Pieces of an Incomplete Puzzle for Lung Cancer Therapy

Current Cancer Drug Targets (2021)

Milad Ashrafizadeh Md Shahinozzaman Sima Orouei Vahideh Zarrin Kiavash Hushmandi

Lung cancer has the first place among cancer-related deaths worldwide and demands novel strategies in the treatment of this life-threatening disorder. The aim of this review is to explore the regulation of epithelial-to-mesenchymal transition (EMT) by long non-coding RNAs (lncRNAs) in lung cancer.LncRNAs can be considered as potential factors for targeting in cancer therapy, since they regulate a bunch of biological processes, e.g. cell proliferation, differentiation and apoptosis. The abnormal expression of lncRNAs occurs in different cancer cells. On the other hand, epithelial-to-mesenchymal transition (EMT) is a critical mechanism participating in migration and metastasis of cancer cells.Different databases, including Google Scholar, Pubmed and Science direct, were searched for collecting articles using keywords such as "LncRNA", "EMT", and "Lung cancer".There are tumor-suppressing lncRNAs that can suppress EMT and metastasis of lung cancer cells. Expression of such lncRNAs undergoes down-regulation in lung cancer progression and restoring their expression is of importance in suppressing lung cancer migration. There are tumor- promoting lncRNAs triggering EMT in lung cancer and enhancing their migration.LncRNAs are potential regulators of EMT in lung cancer, and targeting them, both pharmacologically and genetically, can be of importance in controlling the migration of lung cancer cells.

Crosstalk

10.2174/1568009621666210203110305

Cite

Citations (33)

Nanotechnology for Nasopharyngeal Cancer Therapy and Improving Drug Stability and Biodistribution

Advanced Materials Technologies (2024)

Minmin Shao Madineh Moradialvand Francesca Della Sala Zahra Khorsandi Assunta Borzacchiello

Abstract Nasopharyngeal cancer (NPC) is a challenging malignancy with a poor prognosis due to late diagnosis and resistance to conventional treatments. Nanotechnology offers promising solutions to address these limitations by enabling targeted drug delivery, enhancing therapeutic efficacy, and facilitating multimodal treatment strategies. By leveraging the unique properties of nanomaterials and nanocarrier systems, innovative approaches for early detection, targeted treatment, and multimodal therapy can be developed, paving the way for more effective and personalized management of NPC. This review provides a comprehensive overview of recent developments and applications of nanotechnology in NPC therapy, focusing on improving drug stability, biodistribution, and targeted delivery to NPC tumors.

Biodistribution

Nasopharyngeal cancer

Cancer Therapy

10.1002/admt.202400969

Cite

Citations (0)

Bispecific antibodies as powerful immunotherapeutic agents for urological cancers: Recent innovations based on preclinical and clinical evidence

International Journal of Biological Sciences (2025)

Kiavash Hushmandi Behzad Einollahi E Hui Clarissa Lee Reo Sakaizawa Antonino Glaviano

Conventional immunotherapy has emerged as a key option for cancer treatment. However, its efficacy has been limited in urological cancers, especially prostate cancer, because of the immunosuppressive tumor microenvironment (TME), difficulty in drug delivery, aberrant immune response, and damage to normal cells. Bispecific antibodies (BsAbs) are engineered proteins with two different antigen-binding domains, designed using different technologies and in various formats. BsAb-based tumor immunotherapy has yielded optimistic results in preclinical and clinical investigations of many tumor types, including urological cancers. However, a series of challenges, including tumor heterogeneity, TME, Ab immunogenicity, adverse effects, serum half-life, low response rates, and drug resistance, hamper the application of BsAbs. In this review, we provide insights into the most common BsAb platforms with different mechanisms of action, which are under preclinical and clinical research, along with ways to overcome the challenges in BsAb administration for treating urological cancer.

Bispecific antibody

Tumor immunology

10.7150/ijbs.96155

Cite

Citations (0)

Mortality trend before and after the onset of the Corona crisis: —has the mortality changed its course?

Pars of Jahrom University of Medical Sciences (2021)

Vahid Rahmani Razieh Zehedi Kiavash Hushmandi Karamatollah Rahmanian Leila Fakhravar

Corona (planetary geology)

Course (navigation)

Source

Cite