Chao Xia

Shanghai Jiao Tong University

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Hai‐Ming Guo

Henan Normal University

Gui‐Rong Qu

Henan Normal University

Hong‐Ying Niu

Henan Institute of Science and Technology

Dong‐Chao Wang

Henan Normal University

Wanbin Zhang

Shanghai University

Delong Liu

Shanghai Jiao Tong University

Ming‐Sheng Xie

Henan Normal University

Masashi Sugiya

Nippon Chemical Industrial (Japan)

Tsuneo Imamoto

Chiba University

Zehua Yang

University of South China

Cooperative Institutions

Henan Normal University

Sichuan University

Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

Xinxiang University

Peking Union Medical College Hospital

Chang'an University

Henan Institute of Technology

Henan Institute of Science and Technology

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ChemInform Abstract: P‐Stereogenic PNP Pincer‐Pd Catalyzed Intramolecular Hydroamination of Amino‐1,3‐dienes.

ChemInform (2015)

Zehua Yang Chao Xia Delong Liu Yangang Liu Masashi Sugiya

Abstract Allyl‐type chiral pyrrolidine derivatives are efficiently synthesized by asymmetric intramolecular hydroamination of amino‐1,3‐dienes with excellent regioselectivities and up to moderate enantioselectivities.

Hydroamination

Stereocenter

Pyrrolidine

10.1002/chin.201527148

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Citations (0)

Crystal Structure of Anolis carolinensis MHC I complex

Y. Wang Z.-W. Qu Lei Ma Xue-Lian Wei N. Zhang

Anolis

10.2210/pdb7cpo/pdb

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ChemInform Abstract: A Rapid and Divergent Access to Chiral Azacyclic Nucleoside Analogues via Highly Enantioselective 1,3‐Dipolar Cycloaddition of β‐Nucleobase Substituted Acrylates.

ChemInform (2015)

Qi‐Liang Yang Ming‐Sheng Xie Chao Xia Huanli Sun Dan‐Jie Zhang

Abstract A novel protocol for an asymmetric 1,3‐dipolar cycloaddition of azomethine ylides with β‐nucleobase acrylates gives access to chiral azacyclic nucleosides.

Nucleobase

10.1002/chin.201516296

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The practical acetylation of nucleosides using acetic anhydride/acetic acid as a reusable solvent

Journal of Chemical Research (2022)

Xia Ran Chao Xia Ying-Xing Yang Lijie Liu Leishan Chen

The highly practical acetylation of free nucleosides is achieved using acetic anhydride/acetic acid as a reusable solvent and acetylating regent. A series of nucleosides, including ribosyl, deoxyribosyl, arabinosyl, acyclic and pyranosyl, and many clinical drugs were acetylated efficiently, even on large scale (200 g).

10.1177/17475198221115020

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Citations (1)

Effect of Microstructural Characteristics on Fracture Toughness in Direct Energy Deposited Novel Ti-6Al-4V-1Mo Alloy

Acta Metallurgica Sinica (English Letters) (2024)

Chao Xia Kexin Zhao Xin Zhou Yuqi He Panpan Gao

Titanium alloy

Damage tolerance

Elongation

Toughening

10.1007/s40195-023-01650-4

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Citations (2)

Microwave‐Promoted “One‐Pot” Synthesis of 4‐Nitrobenzylthioinosine Analogues Using Thiourea as a Sulfur Precursor

Chemistry - An Asian Journal (2011)

Hong‐Ying Niu Chao Xia Gui‐Rong Qu Shan Wu Yi Jiang

An efficient one-pot method for the synthesis of various C6-alkylthio-substituted purine nucleosides has been developed under microwave irradiation with good to excellent yields without any metal catalyst (see scheme). This process expands the scope of existing synthetic methodologies and was further successfully applied for synthesis of the biologically important compound 4-nitrobenzylthioinosine (NBTI). Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Scope (computer science)

10.1002/asia.201100699

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Citations (17)

Hydrogen‐Rich Saline Combined With Vacuum Sealing Drainage Promotes Wound Healing by Altering Biotin Metabolism

Journal of Cellular and Molecular Medicine (2025)

Xinwen Kuang Zhengyun Liang Yijun Xia Mengjie Shan Yan Hao

Impaired wound healing affects the life quality of patients and causes a substantial financial burden. Hydrogen-rich medium is reported to have antioxidant and anti-inflammatory effects. However, the role of hydrogen-rich saline (HRS) in cutaneous wound healing remains largely unexplored, especially by metabolomics. Thus, untargeted metabolomics profiling was analysed to study the effects and mechanism of HRS combined with vacuum sealing drainage (VSD) in a rabbit full-thickness wound model. Our results indicated that the combination treatment of HRS and VSD could accelerate wound healing. In vitro experiments further confirmed its effects on HaCaT keratinocytes. We found that 45 metabolites were significantly changed between the VSD + HRS group and the VSD + saline-treated group. Pathway enrichment analysis indicated that biotin metabolism was the potential target pathway. The biochemical interpretation analysis demonstrated that combining HRS and VSD might enhance mitochondrial function, ATP synthesis, and GSH homeostasis by altering biotin metabolism. The detection of representative indicators of oxidative stress supported the critical metabolic pathway analysis as well. In summary, VSD combined with HRS might provide a new strategy to enhance wound healing.

10.1111/jcmm.70292

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Synthesis of 2′-deoxyguanosine from 2′-deoxyadenosine via C2 nitration

Nucleosides Nucleotides & Nucleic Acids (2022)

Xia Ran Leishan Chen Shaohong Xu Chao Xia Li‐Ping Sun

An efficient synthetic method has been developed for the synthesis of 2'-deoxyguanosine from the more commercially available 2'-deoxyadenosine via late-stage C2 nitration in 48.7% total yield by a 5-step synthetic procedure. Crucially, 2'-deoxyadenosine was fully protected by bennzoyl groups and then nitrated at C2 by tetrabutylammonium nitrate/trifluoroacetic anhydride. The resulting 2-NO2 moiety was converted into 2-NH2 by Ni-catalyzed hydrogenolysis. Finally, 2'-deoxyguanosine was obtained from the diaminopurine intermediate by deaminase-catalyzed reaction. Furthermore, the 2-NO2 moiety also appeared to be a versatile handle to introduce a variety of functional groups, resulting in a divergent access to 2-substituted 2'-deoxyadenosine analogues.

Deoxyadenosine

Trifluoroacetic anhydride

Moiety

Deoxyguanosine

Hydrogenolysis

10.1080/15257770.2022.2055060

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Citations (4)

Crystal structure of shark MHC CLASS I for 2.3 angstrom

Yangjie Wu Chao Xia

Angstrom

10.2210/pdb6lup/pdb