Birgit Zirngast

Medical University of Graz

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Co-Authors

Alessio Alogna

Charité - Universitätsmedizin Berlin

Burkert Pieske

Charité - Universitätsmedizin Berlin

Michael Schwarzl

University Medical Center Hamburg-Eppendorf

H. Maechler

Medical University of Graz

David Zweiker

Medical University of Graz

Paul Steendijk

Leiden University Medical Center

Martin Manninger

Medical University of Graz

Heinrich Mächler

Medical University of Graz

Douglas S. Scherr

Medical University of Graz

H. Post

University of Tartu

Cooperative Institutions

Medical University of Graz

University of Graz

Graz University Hospital

Medical University of Vienna

Charité - Universitätsmedizin Berlin

Universität Hamburg

University Medical Center Hamburg-Eppendorf

Universitätsklinik für Chirurgie Wien

German Centre for Cardiovascular Research

Steinhauser (Czechia)

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Haemodynamic effects of acute PDE-5A inhibition in a porcine model of hypertensive heart disease

European Journal of Heart Failure (2014)

Alessio Alogna Michael Schwarzl Birgit Zirngast M Manninger-Wuenscher J. Vederber

Hypertensive heart disease

Hypertensive disease

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P3571Structural remodelling in a porcine model of rapid atrial pacing and arterial hypertension

European Heart Journal (2017)

Martin Manninger Julia Schipke Viktoria Herbst David Zweiker Ursula Rohrer

10.1093/eurheartj/ehx504.p3571

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Subclavian Impella 5.5 implant for perioperative left ventricular dysfunction

Multimedia Manual of Cardio-Thoracic Surgery (2023)

Barbara Karner Melanie Arnreiter Birgit Zirngast Miriam Pavlikova Dietmar Renz

We present the implant method and the postoperative management for an Impella 5.5 device via the right subclavian artery in a 72-year-old patient with severe left ventricular dysfunction upon weaning from cardiopulmonary bypass during a cardiac surgery procedure.

Impella

Left subclavian artery

10.1510/mmcts.2023.048

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Graded lower body negative pressure induces intraventricular negative pressures and incremental diastolic suction: a pressure-volume study in a porcine model

Journal of Applied Physiology (2022)

Leonhard Berboth Birgit Zirngast Martin Manninger Paul Steendijk Carsten Tschöpe

This study examined the effects of incremental lower body negative pressure (LBNP) from −15 to −45 mmHg on hemodynamic regulation using invasive pressure-volume assessment in closed-chest pigs. Graded preload reduction via LBNP induces negative left ventricular (LV) pressures while increasing LV suction and thus allowing the ventricle to eject below the equilibrium volume at the end of systole. Accordingly, LBNP-induced central hypovolemia is associated with increased diastolic suction.

Preload

Hypovolemia

Lower body

End-diastolic volume

End-systolic volume

10.1152/japplphysiol.00110.2022

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Citations (3)

Transapical TAVI in chronic type A dissection

European surgery. Supplement/European surgery (2022)

Christian Mayer Birgit Zirngast Olev Luha W. Marte Johannes Schmid

Summary Background Transcatheter aortic valve implantation (TAVI) has been a routine procedure for quite some years. Advancements in technology and experience have enabled its use in even more challenging anatomies. Case report An 83-year-old female patient with severe aortic pathology due to chronic type A dissection after supracoronary ascending aortic repair was suffering from progressive dyspnea and recurrent cardiac decompensations due to severe aortic stenosis. She was successfully treated with a transapical TAVI procedure by our interdisciplinary heart team. Conclusion Transapical TAVI is a good alternative for overcoming severe aortic pathology when treating aortic stenosis.

10.1007/s10353-022-00754-y

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Der Aortenklappenersatz beim über 80-Jährigen aus der Sicht des herzchirurgischen Partners im multidisziplinären Heart-Team

Journal für Kardiologie (2013)

Heinrich Mächler Birgit Zirngast Andreas Vötsch W. Marte L. Salaymeh

Aortic Valve Replacement in Octogenarians – The View of the Surgeon in the Heart-Team. Regarding improvement in cardiac symptoms, patients older than 80 years benefit significantly from conventional surgical aortic valve replacement. After surgery, longterm survival of this subgroup is comparable to the one of an age-matched population. Transcathether aortic valve implantations on the other hand entail an undisputable benefit in surgical “high risk” patients when it comes to health-related quality of life after an intervention. Emphasis should be placed on improving physical, functional, emotional und mental quality of life and not on mortality rates and prolongation of life when decisions regarding therapeutic pathways are made. Keeping that in mind, heart teams should not only evaluate comorbidity but also frailty as an important predictor for surgical success. Age alone can not be the sole criteria for exclusion from surgical aortic valve replacement. J Kardiol 2013; 20 (9–10): 285–290

Valve replacement

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Limited prediction of incomplete left ventricular relaxation from diastolic time intervals and the isovolumic relaxation constant tau

European Journal of Heart Failure (2013)

Michael Schwarzl Alessio Alogna Birgit Zirngast Paul Steendijk H. Maechler

Isovolumic relaxation time

Time constant

Constant (computer programming)

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The soluble guanylate cyclase (sGC) stimulator BAY 41-8543 exerts a negative inotropic effect in healthy pigs

European Journal of Heart Failure (2014)

Michael Schwarzl Alessio Alogna Birgit Zirngast Paul Steendijk H. Maechler

GUCY1A3

GUCY1B3

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Effects of hyperthermia and mild hypothermia on myocardial function in pigs: comparison to dobutamine

European Heart Journal (2015)

Alessio Alogna M Manninger-Wuenscher Michael Schwarzl Birgit Zirngast J. Verderber

Dobutamine

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Ascending aortic and proximal hemiarch replacement with antegrade cerebral perfusion for a penetrating aortic ulcer

Multimedia Manual of Cardio-Thoracic Surgery (2023)

Melanie Arnreiter Barbara Karner Petra Srekl-Filzmaier Birgit Zirngast Julia Thaler

We report the surgical repair of a penetrating aortic ulcer in the distal ascending aorta close to the brachiocephalic trunk, by supracoronary ascending aortic and hemiarch replacement via a full sternotomy. The procedure is performed under moderate hypothermia with bilateral antegrade cerebral perfusion.

Aortic repair

Cerebral Hypoperfusion

Median sternotomy

10.1510/mmcts.2023.047

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Citations (1)