Janet E. Reing

University of Pittsburgh

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Stephen F. Badylak

McGowan Institute for Regenerative Medicine

Stephen Tottey

Fraunhofer USA

Scott A. Johnson

University of Pittsburgh

Timothy J. Keane

Imperial College London

Li Zhang

Loma Linda University

Kerry A. Daly

University of Pittsburgh

Matthew T. Wolf

National Cancer Institute

Bryan N. Brown

University of Pittsburgh

Ricardo Londoño

University of Pittsburgh

Christopher L. Dearth

Walter Reed National Military Medical Center

Cooperative Institutions

University of Pittsburgh

McGowan Institute for Regenerative Medicine

University of Pittsburgh Medical Center

UPMC Hillman Cancer Center

Children's Hospital of Pittsburgh

Presbyterian Hospital

Cornell University

UPMC Presbyterian

Magee-Womens Research Institute

Harvard University

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The occurrence of chromosome segregational defects is an intrinsic and heritable property of oral squamous cell carcinoma cell lines

Cancer Genetics and Cytogenetics (2004)

Janet E. Reing Susanne M. Gollin William S. Saunders

Chromosome instability

10.1016/j.cancergencyto.2003.08.002

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Citations (17)

Epimorphic regeneration approach to tissue replacement in adult mammals

Proceedings of the National Academy of Sciences (2009)

Vineet Agrawal Scott A. Johnson Janet E. Reing Li Zhang Stephen Tottey

Urodeles and fetal mammals are capable of impressive epimorphic regeneration in a variety of tissues, whereas the typical default response to injury in adult mammals consists of inflammation and scar tissue formation. One component of epimorphic regeneration is the recruitment of resident progenitor and stem cells to a site of injury. Bioactive molecules resulting from degradation of extracellular matrix (ECM) have been shown to recruit a variety of progenitor and stem cells in vitro in adult mammals. The ability to recruit multipotential cells to the site of injury by in vivo administration of chemotactic ECM degradation products in a mammalian model of digit amputation was investigated in the present study. Adult, 6- to 8-week-old C57/BL6 mice were subjected to midsecond phalanx amputation of the third digit of the right hind foot and either treated with chemotactic ECM degradation products or left untreated. At 14 days after amputation, mice treated with ECM degradation products showed an accumulation of heterogeneous cells that expressed markers of multipotency, including Sox2, Sca1, and Rex1 (Zfp42). Cells isolated from the site of amputation were capable of differentiation along neuroectodermal and mesodermal lineages, whereas cells isolated from control mice were capable of differentiation along only mesodermal lineages. The present findings demonstrate the recruitment of endogenous stem cells to a site of injury, and/or their generation/proliferation therein, in response to ECM degradation products.

10.1073/pnas.0905851106

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Citations (158)

Characterization of the 5′ end of the mouse Ent gene encoding the basement membrane protein, entactin

Gene (1993)

Marian E. Durkin Liu Shu-Huang Janet E. Reing Albert E. Chung

5' flanking region

TATA box

Exon trapping

10.1016/0378-1119(93)90205-h

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Citations (6)

Biologic scaffolds composed of central nervous system extracellular matrix

Biomaterials (2012)

Peter M. Crapo Christopher J. Medberry Janet E. Reing Stephen Tottey Yolandi van der Merwe

Decellularization

Regenerative Medicine

Neural tissue engineering

10.1016/j.biomaterials.2012.01.044

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Citations (246)

ECM Degradation Products Recruit Progenitor Cells to a Site of Injury: A Non-blastermal Epimorphic Approach to Regenerative Medicine

S.A. Johnson Stephen Tottey Kathryn B. Hurley Bernard F. Siu Janet E. Reing

Presenting Author: Vineet Agrawal, Scott A. Johnson, Stephen Tottey, Kathryn B. Hurley, Bernard Siu, Janet Reing, Li Zhang, Corresponding Author: Stephen F. Badylak McGowan Institute for Regenerative Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, 15219 Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 Medical Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261

Regenerative Medicine

Center (category theory)

Source

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Citations (0)

Human Bronchial Epithelial Cell Growth on Homologous Versus Heterologous Tissue Extracellular Matrix

Journal of Surgical Research (2021)

Anjani Ravindra William D’Angelo Li Zhang Janet E. Reing Scott A. Johnson

Heterologous

Matrix (chemical analysis)

10.1016/j.jss.2021.01.040

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Citations (8)

The effect of source animal age upon extracellular matrix scaffold properties

Biomaterials (2010)

Stephen Tottey Scott A. Johnson Peter M. Crapo Janet E. Reing Li Zhang

Decellularization

Matrix (chemical analysis)

10.1016/j.biomaterials.2010.09.006

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Citations (127)

Preparation and characterization of a biologic scaffold and hydrogel derived from colonic mucosa

Journal of Biomedical Materials Research Part B Applied Biomaterials (2015)

Timothy J. Keane Jenna L. Dziki Arthur Castelton Denver M. Faulk Victoria Messerschmidt

Abstract Gastrointestinal pathologies, injuries, and defects affect millions of individuals each year. While there are diverse treatment options for these individuals, no ideal solution exists. The repair or replacement of gastrointestinal tissue, therefore, represents a large unmet clinical need. Biomaterials derived from extracellular matrix (ECM) scaffolds have been effectively used to repair or replace numerous tissues throughout the body in both preclinical and clinical studies. Such scaffolds are prepared from decellularized tissues, and the biochemical, structural, and biologic properties vary depending upon the source tissue from which the ECM is derived. Given the potential benefit of a site‐specific ECM scaffold for some applications, the objective of this study was to prepare, characterize, and determine the in vitro and in vivo cell response to ECM derived from porcine colon. Results of this study show that porcine colon can be effectively decellularized while retaining biochemical and structural constituents of the source tissue. Two forms of colonic ECM, scaffold and hydrogel, were shown to be cell friendly and facilitate the polarization of macrophages toward an M2 phenotype both in vitro and in vivo . © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 291–306, 2017.

Decellularization

10.1002/jbm.b.33556

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Citations (48)

The impact of sterilization upon extracellular matrix hydrogel structure and function

Journal of Immunology and Regenerative Medicine (2018)

Lisa J. White Timothy J. Keane Adam Smoulder Li Zhang Arthur A. Castleton

Sterilization

Regenerative Medicine

10.1016/j.regen.2018.04.001

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Citations (18)