Leila Dehghani

Shahid Beheshti University of Medical Sciences

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Vahid Shaygannejad

Isfahan University of Medical Sciences

Rokhsareh Meamar

Isfahan University of Medical Sciences

Rokhsareh Meamar

Isfahan University of Medical Sciences

Mohammad Saadatnia

Isfahan University of Medical Sciences

Soheil Tahani

Isfahan University of Medical Sciences

Hedayat Sahraei

Baqiyatallah University of Medical Sciences

Majid Ghasemi

Isfahan University of Medical Sciences

Masoomeh Kazemi

University of North Carolina at Chapel Hill

Mohammad Hossein Nasr‐Esfahani

Royan Institute

Fariborz Khorvash

Isfahan University of Medical Sciences

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Isfahan University of Medical Sciences

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Tehran University of Medical Sciences

University of Isfahan

Alzahra Medical and Education Center

Shahid Beheshti University of Medical Sciences

University of Warwick

Tabriz University of Medical Sciences

Universal Scientific Education and Research Network

Islamic Azad University Medical Branch of Tehran

University Hospitals Coventry and Warwickshire NHS Trust

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Comparison of acute ischemic stroke evaluation and the etiologic subtypes between university and nonuniversity hospitals in Isfahan, Iran

International Journal of Stroke (2019)

Fariborz Khorvash Mabobeh Khalili Roya Rezvani Habibabadi Nizal Sarafzadegan Mahshid Givi

Background and purpose Performing a proper causative workup for ischemic stroke patients is essential as it guides the direction of primary and secondary preventions. We aim to investigate the etiological evaluation of these patients in university and nonuniversity hospitals. Method We enrolled subjects from the Persian Registry of Cardiovascular Disease–stroke. Stroke patients were categorized base on an etiological-based classification (Trial of Org 10172 in Acute Stroke Treatment or TOAST) into five groups. We also separated patients with ischemic stroke of undetermined etiology due to incomplete standard evaluation from ischemic stroke of undetermined etiology due to negative standard evaluation. The etiological subtypes and diagnostic evaluations were compared between the two hospital groups. Result Ischemic stroke of undetermined etiology was the most common subtype overall (43%). The prevalence of ischemic stroke of undetermined etiology (incomplete standard evaluation) was significantly higher in patients evaluated in nonuniversity hospitals versus university hospital (46.2% vs. 22.3%). Patients with ischemic stroke of undetermined etiology (negative standard evaluation) and large-artery atherosclerosis were significantly more prevalent in university hospitals (10.3% vs. 4.6% and 13.9% vs. 4.4%, respectively). All diagnostic workups were performed more significantly for university hospital patients. Patients with Ischemic stroke of undetermined etiology (negative standard evaluation). Patients were significantly younger (64.91 ± 14.44 vs. 71.42 ± 12.93) and had lower prevalence of risk factors such as hypertension (48.5% vs. 65.4%) and diabetes (19.4% vs. 33.1%) than patients in ischemic stroke of undetermined etiology (incomplete standard evaluation) subgroup. University hospital patients had better clinical outcomes in terms of mortality and degree of disability during one-year follow-up. Conclusion The high clinical burden of ischemic stroke of undetermined etiology especially in nonuniversity hospitals shows the rational for promoting ischemic stroke evaluation and providing specialized stroke centers for these hospitals in a developing country like Iran.

Stroke

10.1177/1747493019828648

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Citations (9)

Identification of Site of Morphine Action in Pregnant Wistar Rat Placenta Tissue: A C14-Morphine Study

DOAJ (DOAJ: Directory of Open Access Journals) (2012)

Leila Dehghani Hedayat Sahraei Masoomeh Kazemi

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Stem Cell-Derived Exosomes as Treatment for Stroke: a Systematic Review

Stem Cell Reviews and Reports (2020)

Leila Dehghani Seyed Mahmoud Hashemi Mohammad Saadatnia Alireza Zali Saeed Oraee-Yazdani

Stem Cell Therapy

Stroke Recovery

Neuroregeneration

Exosome

10.1007/s12015-020-10024-7

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Citations (16)

The Serum Level of Midkine in Patients With Multiple Sclerosis and Neuromyelitis Optica

Basic and Clinical Neuroscience Journal (2021)

Milad Moayednia Leila Dehghani Amir Safi Vahid Shaygannejad Karim Sohrabi

Introduction: Midkine (MK), a heparin-binding growth factor, is involved in neurological diseases by mediating the inflammatory responses through enhancing the leukocyte migration. The present study assesses the serum concentration of this growth factor among newly developed Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO) patients. Methods: The present research, as a cross-sectional study, was performed at Isfahan University of Medical Sciences, Isfahan City, Iran. All samples were selected from patients who visited Kashani and Alzahra hospitals for two years (2014 to 2016). The MK level was assessed in 80 new MS cases, 80 NMO patients, and 80 healthy subjects. After collecting blood sera samples, MK serum level was measured using the ELISA. The obtained data were analyzed in SPSS. Results: The Mean±SD MK level was 1038.58±44.73 pg/mL in the MS group, which was significantly higher than the Mean±SD MK level in the NMO (872.62±55.42 pg/mL) and control groups (605.02±9.42 pg/mL). Conclusion: Overall, these results demonstrated that MK plays a prominent role in inflammatory reactions and neuroautoimmune diseases, especially in MS. So, the MK level may be used for earlier diagnosis and also prevention of disease progression by using a special inhibitor.

Midkine

Neuromyelitis Optica

10.32598/bcn.12.2.1009.2

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The role of stem cell therapy in multiple sclerosis: An overview of the current status of the clinical studies

Advanced Biomedical Research (2016)

AmirPouya Tanhaei Rokhsareh Meamar Shahrzad Nematollahi Leila Dehghani Omid Mirmosayyeb

The complexity of multiple sclerosis (MS) and the incompetence of a large number of promised treatments for MS urge us to plan new and more effective therapeutic approaches that aim to suppress ongoing autoimmune responses and induction of local endogenous regeneration. Emerging data propose that hematopoietic, mesenchymal, and neural stem cells have the potential to restore self-tolerance, provide in situ immunomodulation and neuroprotection, as well as promote regeneration. Thus, in this article, we will first provide an overview of the cell sources for proposed mechanisms that contribute to the beneficial effects of stem cell transplantation, the ideal route and/or timing of stem cell-based therapies for each main stem cell group, and finally, an overview of the current status of stem cell research in clinical trial stages in MS by comparable and healthy therapeutic effects of different stem cell therapies for MS patients.

Stem Cell Therapy

Cell therapy

Regenerative Medicine

10.4103/2277-9175.178791

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Citations (34)

Novel mutation in HTRA1 in a family with diffuse white matter lesions and inflammatory features

Neurology Genetics (2019)

Amin Ziaei Xiaohong Xu Leila Dehghani Carine Bonnard Andreas Zellner

To investigate the possible involvement of germline mutations in a neurologic condition involving diffuse white matter lesions.The patients were 3 siblings born to healthy parents. We performed homozygosity mapping, whole-exome sequencing, site-directed mutagenesis, and immunoblotting.All 3 patients showed clinical manifestations of ataxia, behavioral and mood changes, premature hair loss, memory loss, and lower back pain. In addition, they presented with inflammatory-like features and recurrent rhinitis. MRI showed abnormal diffuse demyelination lesions in the brain and myelitis in the spinal cord. We identified an insertion in high-temperature requirement A (HTRA1), which showed complete segregation in the pedigree. Functional analysis showed the mutation to affect stability and secretion of truncated protein.The patients' clinical manifestations are consistent with cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL; OMIM #600142), which is known to be caused by HTRA1 mutations. Because some aspects of the clinical presentation deviate from those reported for CARASIL, our study expands the spectrum of clinical consequences of loss-of-function mutations in HTRA1.

10.1212/nxg.0000000000000345

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Citations (8)

Serum Bilirubin Level Changes in Multiple Sclerosis Patients

DOAJ (DOAJ: Directory of Open Access Journals) (2018)

Mahdi Barzegar Vahid Shaygannejad Omid Mirmosayyeb Samane Valipour Roya Akbari

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Study of type a and B behavior patterns in patients with multiple sclerosis in an Iranian population.

PubMed (2013)

Vahid Shaygannejad Sedigheh Rezaei Dehnavi Fereshteh Ashtari Somayeh Karimi Leila Dehghani

In adults, throughout life, uniqueness maintains the equivalent; but, it might be tailored in the track of neurological disarrays. As in the partition of cognitive function associated with multiple sclerosis (MS), numerous studies have been performed, but there are very few reports in this area of behavior. The aim of this study was to investigate the prevalence of personality types A and B in relation to individuals' behaviors with MS and type A behavior with demographic characteristics and the level of disability.

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Citations (7)

Correlation of midkine serum level with pro- and anti-inflamatory cytokines in multiple sclerosis.

PubMed (2014)

Vahid Shaygannejad Saeed Montazeri Azam Jamshidian Soheil Tahani Marjan Gharagozloo

Midkine (MK) is a heparin-binding growth factor with promoting effects in inflammatory responses through enhancing leukocytes migration.To study the correlation between MK serum levels and concentration of inflammatory cytokines in Multiple Sclerosis (MS) patients.We evaluated the MK level and its relationship with inflammatory cytokines (IL-17 and IL-23) and anti-inflammatory ones (IL-10 and TGF-β) in multiple sclerosis (MS) patients. The serum concentrations of MK and cytokines were assessed by ELISA in 32 MS patients in comparison with 32 healthy subjects.Our data showed that the MK concentration in MS patients is lower than healthy controls (341.15 ± 40.71 Pg/ml vs. 620.15 ± 98.61 Pg/ml, respectively, p=0.015). We also observed a significant decrease in IL-10, IL-23, and TGF-β cytokine levels in MS patients. There was a significant correlation between MK and IL-23 concentrations in our study (r = +0.829, p≤ 0.001).These results confirm a role for MK in inflammatory reactions in MS.

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Citations (11)

Anxiety of women employees and the process of maternal role

DOAJ (DOAJ: Directory of Open Access Journals) (2013)

Mansoureh Ahmadifaraz Azam Foroughipour Heidarali Abedi Mehrdad Azarbarzin Leila Dehghani

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Citations (3)