Daniela Flondor

Victor Babeș University of Medicine and Pharmacy Timișoara

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Elena-Alina Moacă

Victor Babeș University of Medicine and Pharmacy Timișoara

Claudia Watz

Victor Babeș University of Medicine and Pharmacy Timișoara

George Drăghici

Victor Babeș University of Medicine and Pharmacy Timișoara

Vlad Socoliuc

Romanian Academy

Cornelia Păcurariu

Polytechnic University of Timişoara

Alexandra-Denisa Semenescu

Victor Babeș University of Medicine and Pharmacy Timișoara

Florin Borcan

Victor Babeș University of Medicine and Pharmacy Timișoara

Cristian Andrei Sarău

Victor Babeș University of Medicine and Pharmacy Timișoara

Andrada Iftode

Victor Babeș University of Medicine and Pharmacy Timișoara

Lucian Barbu‐Tudoran

National Institute for Research and Development of Isotopic and Molecular Technologies

Cooperative Institutions

Victor Babeș University of Medicine and Pharmacy Timișoara

Clinical Emergency Hospital Bucharest

West University of Timişoara

Spitalul Clinic Judeţean de Urgenţă "Pius Brînzeu" Timişoara

Polytechnic University of Timişoara

Romanian Academy

National Institute for Research and Development of Isotopic and Molecular Technologies

Iuliu Hațieganu University of Medicine and Pharmacy

Carol Davila University of Medicine and Pharmacy

Spitalul Clinic Dr. Victor Babes

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Synthesis and Characterization of Bioactive Magnetic Nanoparticles from the Perspective of Hyperthermia Applications

Magnetochemistry (2022)

Elena-Alina Moacă Vlad Socoliuc Dana Stoian Claudia Watz Daniela Flondor

Magnetic iron oxide nanoparticles were obtained for the first time via the green chemistry approach, starting from two aqueous extracts of wormwood (Artemisia absinthium L.), both leaf and stems. In order to obtain magnetic nanoparticles suitable for medical purposes, more precisely with hyperthermia inducing features, a synthesis reaction was conducted, both at room temperature (25 °C) and at 80 °C, and with two formulations of the precipitation agent. Both the quality and stability of the synthesized magnetic iron oxide nanoparticles were physiochemically characterized: phase composition (X-ray powder diffraction (XRD)), thermal behavior (thermogravimetry (TG) and differential scanning calorimetry (DSC)), electron microscopy (scanning (SEM) and transmission (TEM)), and magnetic properties (DC and HF-AC). The magnetic investigation of the as-obtained magnetic iron oxide nanoparticles revealed that the synthesis at 80 °C using a mixture of NaOH and NH3(aq) increases their diameter and implicitly enhances their specific absorption rate (SAR), a mandatory parameter for practical applications in hyperthermia.

Iron oxide nanoparticles

Magnetic hyperthermia

Thermogravimetry

10.3390/magnetochemistry8110145

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Citations (10)

Biosynthesis of Iron Oxide Nanoparticles: Physico-Chemical Characterization and Their In Vitro Cytotoxicity on Healthy and Tumorigenic Cell Lines

Nanomaterials (2022)

Elena-Alina Moacă Claudia Watz Daniela Flondor Cornelia Păcurariu Lucian Barbu‐Tudoran

Iron oxide nanoparticles were synthesized starting from two aqueous extracts based on Artemisia absinthium L. leaf and stems, employing a simplest, eco-friendliness and low toxicity method-green synthesis. The nanoparticles were characterized by powder X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FT-IR), X-ray fluorescence analysis (XRF), thermal analysis (TG/DSC), and scanning electron microscopy (SEM). Lack of magnetic properties and the reddish-brown color of all the samples confirms the presence of hematite as majority phase. The FTIR bands located at 435 cm-1 and 590 cm-1, are assigned to Fe-O stretching vibration from hematite, confirming the formation of α-Fe2O3 nanoparticles (NPs). The in vitro screening of the samples revealed that the healthy cell line (HaCaT) presents a good viability (above 80%) after exposure to iron oxide NPs and lack of apoptotic features, while the tumorigenic cell lines manifested a higher sensitivity, especially the melanoma cells (A375) when exposed to concentration of 500 µg/mL iron oxide NPs for 72 h. Moreover, A375 cells elicited significant apoptotic markers under these parameters (concentration of 500 µg/mL iron oxide NPs for a contact time of 72 h).

HaCaT

Iron oxide nanoparticles

Viability assay

10.3390/nano12122012

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Citations (25)

P02-24 Biologic impact of green solid-lipid nanoparticles on bronchial 3D human reconstructed tissue

Toxicology Letters (2024)

Elena-Alina Moacă I. Marcovici Alexandra-Denisa Semenescu Alex-Robert Jîjie Tudor Mateescu

Solid lipid nanoparticle

10.1016/j.toxlet.2024.07.294

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Oleogel Formulations for the Topical Delivery of Betulin and Lupeol in Skin Injuries—Preparation, Physicochemical Characterization, and Pharmaco-Toxicological Evaluation

Molecules (2021)

Ramona Parvanescu Claudia Watz Elena-Alina Moacă Lavinia Vlaia Iasmina Marcovici

The skin integrity is essential due to its pivotal role as a biological barrier against external noxious factors. Pentacyclic triterpenes stand as valuable plant-derived natural compounds in the treatment of skin injuries due to their anti-inflammatory, antioxidant, antimicrobial, and healing properties. Consequently, the primary aim of the current investigation was the development as well as the physicochemical and pharmaco-toxicological characterization of betulin- and lupeol-based oleogels (Bet OG and Lup OG) for topical application in skin injuries. The results revealed suitable pH as well as organoleptic, rheological, and textural properties. The penetration and permeation of Bet and Lup oleogels through porcine ear skin as well as the retention of both oleogels in the skin were demonstrated through ex vivo studies. In vitro, Bet OG and Lup OG showed good biocompatibility on HaCaT human immortalized cells. Moreover, Bet OG exerted a potent wound-healing property by stimulating the migration of the HaCaT cells. The in ovo results demonstrated the non-irritative potential of the developed formulations. Additionally, the undertaken in vivo investigation indicated a positive effect of oleogels treatment on skin parameters by increasing skin hydration and decreasing erythema. In conclusion, oleogel formulations are ideal for the local delivery of betulin and lupeol in skin disorders.

Lupeol

HaCaT

Betulin

Human skin

Squalene

10.3390/molecules26144174

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Citations (13)

Laryngeal malignancies – epidemiological data and particularities of the cases diagnosed in Western Romania (October 2016–July 2020)

Romanian Journal of Morphology and Embryology (2022)

Adrian Mihail Sitaru Daniela Flondor Ștefania Dinu Ioana Delia Horhat Andrada Iftode

In the last decade, the incidence and mortality associated with laryngeal malignancies has experienced an unfavorable evolution in Romania, in terms of this pathology the country that has become the leader, among the European Union (EU)-27 countries. The aim of the present retrospective study was to analyze the epidemiological data regarding laryngeal cancer and histopathological (HP) particularities in patients diagnosed in Western Romania. Within three years and 10 months (during October 2016-July 2020) in Ear, Nose and Throat (ENT) Clinic of Timişoara Municipal Emergency Clinical Hospital, 194 patients with laryngeal neoplasms (LN) were diagnosed. Most of the patients were male (93.8%), from Timiş County, mainly and the neighboring Counties of Caraş-Severin, Hunedoara, Mehedinţi and Arad. Patient's average age (both sexes) was 62.6 years, with a range from 38 to 84 years and the highest percentages in the 60+ age group (48%). Regarding smoker status, the main cause of the development of the LN, 93.9% of patients were active ones. Regarding localization [International Classification of Diseases 11th Revision (ICD-11)], about 69% were malignant neoplasm of glottis (C32.0), followed by supraglottis (C32.1), larynx-unspecified (C32.9), and subglottis (C32.2). From the HP point of view, several types of tumors were identified, most of which were non-keratinized and keratinized squamous cell carcinomas (about 90%). In addition, there were identified types of verrucous carcinoma, acantholytic carcinoma, squamous papilloma, a possible pleomorphic sarcoma, and pyogenic granuloma. The data presented in this study highlight the growing incidence of LN, which mainly affect men, at an increasingly young age. It is imperative to involve specialists from nutrition, general medicine, ENT, dentistry to start awareness programs and to develop prevention protocols.

10.47162/rjme.63.1.16

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Citations (2)

Lactate Profile Assessment—A Good Predictor of Prognosis in Patients with COVID-19 and Septic Shock Requiring Continuous Renal Therapy

Clinics and Practice (2024)

Cosmin Iosif Trebuian Adina Maria Marza Raul Chioibaş Dumitru Șutoi Alina Petrică

Introduction: Lactate is a useful prognostic marker, as its level increases in hypoxic tissue and/or during accelerated aerobic glycolysis due to excessive beta-adrenergic stimulation and decreased lactate clearance. The Surviving Sepsis Campaign Bundle 2018 Update suggests premeasurement of lactate within 2–4 h so that physicians perform, assist, administer, and introduce lactate-guided resuscitation to reduce mortality due to sepsis. Methods: A total of 108 patients with septic shock who underwent continuous renal replacement therapy (CRRT) for acute kidney injury were enrolled in this observational study. Demographic, clinical, and laboratory data were collected, and patients were divided into two groups: survivors and non-survivors. Results: Multivariate analysis demonstrated that lactate levels at 24 h after initiation of CRRT treatment, but not lactate levels at intensive care unit (ICU) admission, were associated with mortality. Lactate clearance was associated with lower mortality among the survivors (OR = 0.140) at 6 h after ICU admission and late mortality (OR = 0.260) after 24 h. The area under the ROC curves for mortality was 0.682 for initial lactate; 0.797 for lactate at 24 h; and 0.816 for lactate clearance at 24 h. Conclusions: Our result reinforces that the determination of lactate dynamics represents a good predictor for mortality, and serial lactate measurements may be more useful prognostic markers than initial lactate in patients with septic shock.

Renal replacement therapy

Hyperlactatemia

10.3390/clinpract14030078

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Citations (1)