A generous donor: A dinuclear octahedral bis(μ-hydrido)dinickel(II) complex (see picture; C gray, H black, N blue, Ni green) acts as an electron donor to reduce electron acceptors such as methyl viologen. The complex is proposed as a functional model for the dihydride intermediate of an NiRu hydrogenase mimic and, by extension, of [NiFe]hydrogenase itself. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Abstract The enantiomers of title compounds (I) are resolved by column chromatography on a chiral phase [successful only in the case of benzoate (Ib)] or, on a larger scale, kinetically by asymm. epoxidation of (±)‐(Ia) to yield a mixture of ( +)‐(Ia) and (‐ )‐(ll).
A beta-(1 --> 3)-d-glucan schizophyllan (SPG) forms a stoichiometric complex with some polynucleotides. This communication describes our attempt to apply the SPG complex to deliver CpG DNA to endosomes to enhance cytokine secretion. To increase cellular uptake, we introduced spermine, arginine-glycine-aspartic acid tripeptide, octaarginine, or cholesterol to the SPG side chain. The chemically modified SPG showed essentially no cytotoxicity. When CpG DNA complex made therefrom was exposed to macrophages, dramatic enhancement in the cytokine secretion was observed. It increased 5-10 times from the naked dose and 100 times from the background. This performance promises that SPG can be an excellent carrier for CpG DNA.
The Cover Feature shows a slim genie (hydrogenase) who oxidizes H2 and releases energy in the manner of a fuel cell, and a fat genie (photosystem II) that oxidizes H2O by absorbing energy, in the manner of a solar cell. In their Communication, M. Kikkawa et al. demonstrate that a single Ir catalyst is capable of mimicking both systems. By using the Ir complex as the H2- or H2O-oxidizing anode catalyst and carbon black-supported platinum as the O2-reducing cathode catalyst, the functionality of the whole cell can be switched between fuel cell-type and solar cell-type. More information can be found in the Communication by M. Kikkawa et al. on page 4024 in Issue 21, 2017 (DOI: 10.1002/cctc.201700995).
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
