Norberto Cysne Coimbra

Universidade de São Paulo

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Renato Leonardo de Freitas

Universidade de São Paulo

Priscila Medeiros

Universidade de São Paulo

Rafael Carvalho Almada

Universidade de São Paulo

Luiz Luciano Falconi‐Sobrinho

Universidade de São Paulo

Tayllon dos Anjos‐Garcia

Universidade Federal de Alfenas

Marcus Lira Brandão

Universidade de São Paulo

Ricardo de Oliveira

Universidade Federal de Mato Grosso

Juliana Almeida da Silva

Universidade de São Paulo

Audrey Franceschi Biagioni

Scuola Internazionale Superiore di Studi Avanzati

Tatiana Paschoalin-Maurin

Universidade de São Paulo

Cooperative Institutions

Universidade de São Paulo

272

Universidade de Ribeirão Preto

144

Instituto de Neurociências e Comportamento

Clinics Hospital of Ribeirão Preto

Universidade Brasil

Universidade Estadual Paulista (Unesp)

Hospital Universitário da Universidade de São Paulo

Universidade Federal de São Paulo

Universidade Estadual de Campinas (UNICAMP)

Universidade Federal de Mato Grosso

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Nicotinic and muscarinic cholinergic receptors are recruited by acetylcholine-mediated neurotransmission within the locus coeruleus during the organisation of post-ictal antinociception

Brain Research Bulletin (2016)

Rithiele Cristina de Oliveira Ricardo de Oliveira Audrey Franceschi Biagioni Luiz Luciano Falconi‐Sobrinho Tayllon dos Anjos‐Garcia

Mecamylamine

Muscarinic antagonist

10.1016/j.brainresbull.2016.08.011

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Citations (7)

Preparing for the COVID-19 Mental Health Crisis in Latin America – Using Early Evidence From Countries That Experienced COVID-19 First

Alberto Abad Juliana Almeida da Silva João Braga Priscila Medeiros Renato Leonardo de Freitas

The Covid-19 started in China and took over the world, becoming a pandemic. Especially in Latin America, the coronavirus arrived on the continent in mid-February 2020. The South American continent is going through a delicate political, economic and social moment, which is reflected in the fragility of our health systems and science and to reduce the rates of contagion and not overburden health services, including hospitals. Nevertheless, several studies are being carried out in Brazil and worldwide, with the objective sought to understand the characteristics, and even, the cure of people infected by the coronavirus. Therefore, we must consider science-based strategies to combat the pandemic and promote a health system that takes care of the population that needs it.

Pandemic

Coronavirus

10.20944/preprints202005.0018.v1

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Physical, Emotional, and Social Pain During COVID-19 Pandemic-Related Social Isolation

Trends in Psychology (2022)

Priscila Medeiros Ana Carolina Medeiros Jade Pisssamiglio Cysne Coimbra Lucas Emmanuel Pedro de Paiva Teixeira Carlos José Salgado-Rohner

Social Isolation

Isolation

Social distance

Disconnection

Distancing

Pandemic

10.1007/s43076-022-00149-8

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Citations (3)

Lateralization in Hemiparkinsonian Rats Is Affected by either Deep Brain Stimulation or Glutamatergic Neurotransmission in the Inferior Colliculus

eNeuro (2022)

Liana Melo-Thomas Lars Tacken Nicole Richter Davina de Almeida Catarina Rapôso

Abstract After unilateral lesion of the medial forebrain bundle by 6-OHDA rats exhibit lateralized deficits in spontaneous behavior or apomorphine-induced rotations. We investigated whether such lateralization is attenuated by either deep brain stimulation (DBS) or glutamatergic neurotransmission in the inferior colliculus (IC) of Wistar rats. Intracollicular DBS did not affect spontaneous lateralization but attenuated apomorphine-induced rotations. Spontaneous lateralization disappeared after either the glutamatergic antagonist MK-801 or the agonist NMDA microinjections into the IC. Apomorphine-induced rotations were potentiated by MK-801 but were not affected by NMDA intracollicular microinjection. After injecting a bidirectional neural tract tracer into the IC, cell bodies and/or axonal fibers were found in the periaqueductal gray matter, superior colliculus, substantia nigra, cuneiform nucleus, and pedunculo-pontine tegmental nucleus, suggesting the involvement of these structures in the motor improvement after IC manipulation. Importantly, the side of the IC microinjection regarding the lesion (ipsilateral or contralateral) is particularly important, and this effect may not involve the neostriatum directly.

Medial forebrain bundle

Superior colliculus

10.1523/eneuro.0076-22.2022

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Citations (1)

The Primary Motor Cortex Stimulation Attenuates Cold Allodynia in a Chronic Peripheral Neuropathic Pain Condition in <i>Rattus norvegicus</i>

World Journal of Neuroscience (2019)

Priscila Medeiros Sylmara Esther Negrini-Ferrari Ana Carolina Medeiros Laís Ferreira Josie Resende Torres da Silva

Background: The primary motor cortex (M1) stimulation (MCS) is a useful tool for attenuation of the peripheral neuropathic pain in patients with pharmacologically refractory pain. Furthermore, that neurological procedure may also cause antinociception in rodents with neuropathic pain. Cold allodynia is a frequent clinical finding in patients with neuropathic pain, then, we evaluated if an adapted model of neuropathy induced by chronic constriction injury (CCI) of the ischiadicus nervus (sciatic nerve) produces cold allodynia in an animal model of chronic pain. In addition, we also investigated the effect of the electrical stimulation of the M1 on chronic neuropathic pain condition in laboratory animals. Methods: Male Wistar rats were used. An adapted model of peripheral mononeuropathy induced by CCI was carried out by placing a single loose ligature around the right sciatic nerve. The acetone test was used to evaluate the cold allodynia in CCI or Sham (without ligature) rats. The MCS (M1) was performed at low-frequency (20 μA, 100 Hz) during 15 s by deep brain stimulation (DBS-Thomas Recording device) 21 days after CCI or Sham procedures. The cold allodynia was measured before and immediately after the neurostimulation of M1 in the following time-window: 0, 15 and 30 min after MCS. Results: Cold allodynia threshold increased in animals with chronic neuropathic pain submitted to the acetone test 21 days after the CCI surgery. The M1-stimulation by DBS procedure decreased the cold allodynia immediately and until 30 min after M1-stimulation in rats with chronic neuropathic pain. Conclusion: The current proposal for a CCI model by a single loose ligature of the sciatic nerve can be employed as an experimental model of chronic neuropathic pain in rats submitted to peripheral nervous system injury. The M1-stimulation produced antinociception in rats with chronic neuropathic pain. Thus, we reinforced that the MCS decreases cold allodynia in laboratory animals submitted to persistent sciatic nerve constriction and can be a more reasonable procedure for the treatment of chronic intractable neuropathic pain.

Allodynia

10.4236/wjns.2019.93009

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Citations (8)

Neural substrate of defensive behavior in the midbrain tectum

Neuroscience & Biobehavioral Reviews (1994)

Marcus Lira Brandão Sílvia Helena Cardoso Lauro Melo V. Motta Norberto Cysne Coimbra

Superior colliculus

Periaqueductal gray

Tectum

Neural substrate

Escape response