Tijana Borovski

Academic Medical Center

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Jan Paul Medema

University of Amsterdam

Louis Vermeulen

Cancer Center Amsterdam

Joost J.C. Verhoeff

University Medical Center Utrecht

Lev Naumov

Leibniz Institute for Baltic Sea Research

Shannon K. McWeeney

Oregon Health & Science University

Andrea Sottoriva

Institute of Cancer Research

P.M.A. Sloot

University of Amsterdam

Inne H.M. Borel Rinkes

University Medical Center Utrecht

Szabolcs Fátrai

Merus (Netherlands)

Onno Kranenburg

University Medical Center Utrecht

Cooperative Institutions

The University of Texas MD Anderson Cancer Center

Washington University in St. Louis

University of Amsterdam

Academic Medical Center

University of California, Davis

University Medical Center Utrecht

Amsterdam University Medical Centers

Harvard University

James S. McDonnell Foundation

Baylor College of Medicine

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Cancer Stem Cell Niche: The Place to Be

Cancer Research (2011)

Tijana Borovski Felipe de Sousa e Melo Louis Vermeulen Jan Paul Medema

Tumors are being increasingly perceived as abnormal organs that, in many respects, recapitulate the outgrowth and differentiation patterns of normal tissues. In line with this idea is the observation that only a small fraction of tumor cells is capable of initiating a new tumor. Because of the features that these cells share with somatic stem cells, they have been termed cancer stem cells (CSC). Normal stem cells reside in a "stem cell niche" that maintains them in a stem-like state. Recent data suggest that CSCs also rely on a similar niche, dubbed the "CSC niche," which controls their self-renewal and differentiation. Moreover, CSCs can be generated by the microenvironment through induction of CSC features in more differentiated tumor cells. In addition to a role in CSC maintenance, the microenvironment is hypothesized to be involved in metastasis by induction of the epithelial-mesenchymal transition, leading to dissemination and invasion of tumor cells. The localization of secondary tumors also seems to be orchestrated by the microenvironment, which is suggested to form a premetastatic niche. Thus, the microenvironment seems to be of crucial importance for primary tumor growth as well as metastasis formation. Combined with its role in the protection of CSCs against genotoxic insults, these data strongly put forward the niche as an important target for novel therapies.

Stem cell niche

10.1158/0008-5472.can-10-3220

Cite

Citations (500)

Inhibition of homologous recombination by hyperthermia shunts early double strand break repair to non-homologous end-joining

DNA repair (2012)

Judith W.J. Bergs Przemek M. Krawczyk Tijana Borovski Rosemarie ten Cate Hans M. Rodermond

Non-homologous end joining

Premature chromosome condensation

10.1016/j.dnarep.2012.10.008

Cite

Citations (46)

Supplementary Movie 2 from Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity

Andrea Sottoriva Joost J.C. Verhoeff Tijana Borovski Shannon K. McWeeney Lev Naumov

Supplementary Movie 2 from Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity

Morphology

Tumor Heterogeneity

10.1158/0008-5472.22382793.v1

Cite

Citations (0)

Supplementary Movie 1 from Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity

Andrea Sottoriva Joost J.C. Verhoeff Tijana Borovski Shannon K. McWeeney Lev Naumov

Supplementary Movie 1 from Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity

Morphology

Tumor Heterogeneity

10.1158/0008-5472.22382796

Cite

Citations (0)

Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity

Cancer Research (2010)

Andrea Sottoriva Joost J.C. Verhoeff Tijana Borovski Shannon K. McWeeney Lev Naumov

Abstract The recently developed concept of cancer stem cells (CSC) sheds new light on various aspects of tumor growth and progression. Here, we present a mathematical model of malignancies to investigate how a hierarchical organized cancer cell population affects the fundamental properties of solid malignancies. We establish that tumors modeled in a CSC context more faithfully resemble human malignancies and show invasive behavior, whereas tumors without a CSC hierarchy do not. These findings are corroborated by in vitro studies. In addition, we provide evidence that the CSC model is accompanied by highly altered evolutionary dynamics compared with the ones predicted to exist in a stochastic, nonhierarchical tumor model. Our main findings indicate that the CSC model allows for significantly higher tumor heterogeneity, which may affect therapy resistance. Moreover, we show that therapy which fails to target the CSC population is not only unsuccessful in curing the patient, but also promotes malignant features in the recurring tumor. These include rapid expansion, increased invasion, and enhanced heterogeneity. Cancer Res; 70(1); 46–56

Tumor progression

10.1158/0008-5472.can-09-3663

Cite

Citations (203)

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

Nature Cell Biology (2010)

Louis Vermeulen Felipe de Sousa e Melo Maartje van der Heijden Kate Cameron Joan H. de Jong

Beta-catenin

10.1038/ncb2048

Cite

Citations (1,727)

Supplementary tables S1-6 from SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer

Thomas T. Vellinga Tijana Borovski Vincent C. J. de Boer Szabolcs Fátrai Susanne van Schelven

<p>Supplementary tables S1-6. Supplementary table S1 Primers used for RT-qPCR analyses. Supplementary table S2 Clinical variables associated with differences in gene expression among 119 resected liver metastases. Supplementary table S3 613 genes whose expression was significantly upregulated and 481 genes whose expression was significantly (p<0.05) down-regulated in chemotherapy-treated tumors compared to chemo-naive tumors. Supplementary table S4 KEGG pathway finder analysis and Ingenuity Pathway Analysis of upregulated genes in chemo-treated compared to chemo-naive tumors. Supplementary table S5 P-values of expression levels of genes involved in mitochondrial dysfunction, ubiquinone synthesis and mitochondrial biogenesis upregulated in chemo-treated compared to chemo-naive tumors. Supplementary table S6 (additional information regarding the calculation listed below) ATP synthesis rates through glycolysis and OXPHOS.</p>

KEGG

Table (database)

10.1158/1078-0432.22460445.v1

Cite

Citations (0)

Free Article from Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity

Andrea Sottoriva Joost J.C. Verhoeff Tijana Borovski Shannon K. McWeeney Lev Naumov

Free Article from Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity

Morphology

10.1158/0008-5472.22382802

Cite

Citations (0)

Supplementary Materials and Methods, Figures 1-8, Tables 1-3, Movie Legends 1-6 from Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity

Andrea Sottoriva Joost J.C. Verhoeff Tijana Borovski Shannon K. McWeeney Lev Naumov

Supplementary Materials and Methods, Figures 1-8, Tables 1-3, Movie Legends 1-6 from Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity

Morphology

10.1158/0008-5472.22382799.v1

Cite

Citations (0)

Supplementary Movie 4 from Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity

Andrea Sottoriva Joost J.C. Verhoeff Tijana Borovski Shannon K. McWeeney Lev Naumov

Supplementary Movie 4 from Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity

Morphology

10.1158/0008-5472.22382787.v1

Cite

Citations (0)