Gina S. El-Feky

Academy of Scientific Research and Technology

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Gamal Zayed

Al-Azhar University

Mona M. El-Naa

University of Sadat City

Azza A. Mahmoud

Future University in Egypt

Rabab Kamel

National Research Centre

Mohamed F. Attia

University of North Carolina at Chapel Hill

Sanaa S. Botros

Theodor Bilharz Research Institute

A. Salem

Suez Canal University

Abd El-Monem Abd El-Kader El-Torgoman

Menoufia University

Samah El-Ghlban

Menoufia University

Mahmoud M. Sakr

Academy of Scientific Research and Technology

Cooperative Institutions

National Research Centre

National Water Research Center

Cairo University

Menoufia University

Ain Shams University

Textile Research Institute

Egypt Center for Research and Regenerative Medicine

Beni-Suef University

Academy of Scientific Research and Technology

Assiut University

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ENHANCEMENT OF ORAL BIOAVAILABILITY OF REPAGLINIDE BY SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM

International Journal of Pharmacy and Pharmaceutical Sciences (2014)

Hussein O. Ammar Gina S. El-Feky Ahmed Mahmoud Abdelhaleem Ali Rami A. Galil Dawood

Repaglinide is considered the drug of choice for diabetic patients with impaired kidney function as it is excreted mainly in the bile. Unfortunately, it possesses low oral bioavailability of approximately 56 %. Therefore, nano-sized globules containing the drug are expected to enhance its bioavailability and sustain its glucose lowering action. Self nano-emulsifying drug delivery systems (SNEDDS) of repaglinide have been prepared for improving the water solubility and oral bioavailability of the drug. Various compositions of SNEDDS were prepared using four types of oils (oleic acid, isopropyl myristate IPM. Labrafil 1944 and 2125), surfactants (chromophore El35, chromophore RH 40, Labrasol and Span 20) and a variety of co-surfacatnts. Low energy emulsification was adopted as the method of preparation for its feasibility and low cost. The prepared nano-emulsions showed small average droplet size (13.5-20 nm) and low polydispersity index (0.10 - 0.30). In-vitro dissolution studies indicated that the drug release from some of the prepared nanoemulsion droplets reached 75 % within the first 30 minutes. The i n-vivo data demonstrated that repaglinide in the nano-emulsion formulations F8 (IPM, Cremophor EL35 and Propylene glycol) and F16 (Oleic acid, Cremophor RH40 and Lauroglycol FCC) lowered the plasma glucose level (< 110 mg/dL) of experimental rabbits in a similar trend to that of the commercial product (Novonorm ® ), moreover, it caused an excess reduction in blood glucose level at the end of the 24 hrs period by virtue of its long circulation time compared to the marketed formula.

Repaglinide

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Citations (3)

Using chitosan nanoparticles as drug carriers for the development of a silver sulfadiazine wound dressing

Carbohydrate Polymers (2016)

Gina S. El-Feky S. Sharaf A. El-Shafei Aisha A. Hegazy

Silver sulfadiazine

Wound dressing

Dispersity

Bacterial growth

10.1016/j.carbpol.2016.11.054

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Citations (74)

Case Studies in International Science Diplomacy: ASRT Contribution to Developing S&T in Egypt

Research for development (2023)

Sameh H. Soror Gina S. El-Feky Abeer Attia Mahmoud M. Sakr

10.1007/978-981-19-6802-0_15

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PLGA NANOPARTICLES LOADED MUCOADHESIVE AND THERMOSENSITIVE HYDROGEL AS A POTENTIAL PLATFORM FOR THE TREATMENT OF ORAL MUCOSITIS

International Journal of Applied Pharmaceutics (2019)

Gina S. El-Feky Gamal Zayed

Objective: The objective of this study was to design an effective topical treatment for oral mucositis.Methods: Poly-(DL-lactide-co-glycolide) (PLGA) nanoparticles (NPs) and Poloxamer407 (PLX)/Hydroxy propyl methyl cellulose (HPMC) hydrogel matrix (HG) were used as combined carriers for benzydamine HCL (BNZ). BNZ loaded PLGA nanoparticles were assessed for their particle size, PDI, zeta potential and entrapment efficiency. Scanning electron microscopy, thermosensitivity study, mucoadhesion study, in vitro release and in vivo investigation were used to characterize the combined BZN loaded PLGA NPs HG.Results: Negatively charged NPs with an average diameter of 139±4.92 nm were incorporated into PLX/HPMC HG bases. The gelation temperature of BZN-PLGA-NPs-HGs ranged between 31°C and 36.5°C. When diluted with saliva simulated fluid, BZN-PLGA-NPs-HGs preserved their gelation properties. Mucoadhesion was found lower for formulations prepared with PLX without HPMC. An increase in the concentrations of PLX from 10 to 30% resulted in an increase in adhesion. Both PLGA-NPs and PLGA-NPs-HG provided a biphasic drug release profile while BZN-HG provided monophasic zero order release pattern. The in vivo study showed that animal groups treated with BZN-HG and BZN-PLGA-NPs-HG showed a significantly higher reduction percentage in ulcer surface area compared to those treated with BZN-PLGA-NPs. BZN-PLGA-NPs-HG group needed 10 d of treatment to complete healing versus 16 d, 14 d and 12 d for the complete healing of groups with no treatment, treated with BZN-PLGA-NPs and treated with BZN-HG, respectively.Conclusion: BZN-PLGA-NPs-HG could represent a promising mean for the effective treatment of oral mucositis induced by cancer therapy.

PLGA

Mucoadhesion

Zeta potential

Mucositis

10.22159/ijap.2019v11i1.29466

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Corrigendum to “Miglitol-PMO nanoparticles, an alpha-glucosidase inhibitor, has prolonged action on blood glucose level in diabetic rats” [J. Drug Deliv. Sci. Technol. 72 (2022) 103388]

Journal of Drug Delivery Science and Technology (2022)

A. Salem Amira Montaser Mona M. El-Naa Gina S. El-Feky Samah El-Ghlban

Alpha (finance)

10.1016/j.jddst.2022.103647

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Antibacterial Activity of Thirty Two Pomegranate (Punica granatum L.) Accessions Growing in Egypt Fruit Peels

Neveen A. Hassan Gina S. El-Feky Hend M. Elegami

3 Abstract: The ethanol extracts of thirty two Punica granatum L. from different region of Egypt, were used for the investigation of antibacterial studies. In antibacterial screening performed by agar well diffusion method against four human pathogen (Escherichia coli and Pseudomonas aeruginosa as gram negative (G-ve) bacteria and Staphylococcus aureus and Streptococcus faecalis as gram positive (G+ve) bacteria) and two plant pathogen (Erwinia cartovora and Xanthomonase campestris as gram negative (G-ve) bacteria), it was found that the ethanol extracts of all the plant samples showed activity against all tested bacteria. The ethanol extracts of Punica granatum exhibited clear zone of inhibition against the tested micro organisms. The results revealed that plant extracts especially some obtained from Assuit and North Saini had a strong antibacterial activity against all tested bacteria

Punica

Pathogenic bacteria

Gram-Negative Bacteria

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Flexible nano-sized lipid vesicles for the transdermal delivery of colchicine; in vitro/in vivo investigation

Journal of Drug Delivery Science and Technology (2018)

Gina S. El-Feky Mona M. El-Naa Azza A. Mahmoud

Ex vivo

Zeta potential

10.1016/j.jddst.2018.10.036

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Citations (24)

Miglitol-PMO nanoparticles, an alpha-glucosidase inhibitor, has prolonged action on blood glucose level in diabetic rats

Journal of Drug Delivery Science and Technology (2022)

A. Salem Ahmed Saeed Saad Mona M. El-Naa Gina S. El-Feky Samah El-Ghlban

10.1016/j.jddst.2022.103388

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Citations (2)

Double-phase hydrogel for buccal delivery of tramadol

Drug Development and Industrial Pharmacy (2011)

Rabab Kamel Azza A. Mahmoud Gina S. El-Feky

Context: Treatment of chronic pain is complicated by the evidence that abuse of prescription opioids is rising; therefore, in many cases, chronic pain remains undertreated. Tramadol is an atypical central analgesic with a mixed mechanism of action offering many advantages over conventional opioids. Objective: We exploited the nonopioid action of tramadol, by bypassing the first-pass effect, as well as multiparticulate drug delivery. Our aim was to identify optimal formulation parameters for designing polyvinyl alcohol (PVA), single and mixed dual cross-linked tramadol microspheres-loaded hydrogel with adequate bioadhesion and providing controlled drug release for buccal delivery. Methods: Microspheres characterization was done by scanning electron microscopy and infrared spectroscopy. Other investigations comprised the evaluation of yield, drug content, particle size, rheology, swelling, mucoadhesion, release, and permeation studies through biological membranes all together with testing the antinociceptive activity and its attenuation by the antagonist naloxone HCl. Results and conclusion: PVA-alginate microspheres (F3)-loaded carbopol hydrogel attained: the highest mucoadhesion time (1436.67 min ± 5.77) and mucin adsorption capacity, shear thinning thixotropic properties with adequate yield value and hysteresis area, best drug release (RE = 84.20 ± 2.07%) and permeation efficiency (PE = 65.30 ± 7.02%). Dissolution and permeation profiles were compared using similarity factor; F3-loaded carbogel had the lowest value. During in vivo study, the nonsignificant difference between the AUC of the groups receiving F3-loaded carbogel buccally with (group 5) and without (group 4) administration of naloxone, and between group 4 and the oral group, showed that the buccal route may arguably provide an alternative safer route of tramadol administration.

Mucoadhesion

Polyvinyl Alcohol

Thixotropy

10.3109/03639045.2011.611807

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Citations (26)

The Egypt Genome Project

Nature Genetics (2024)

Mohamed A. Elmonem Neveen A. Soliman Ahmed M. Moustafa Yehia Z. Gad Wael A. Hassan

Sequence (biology)

10.1038/s41588-024-01739-1

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Citations (5)