Carlotta Ginevra Nucci

Istituti di Ricovero e Cura a Carattere Scientifico

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Francesco Doglietto

Agostino Gemelli University Polyclinic

Pasquale De Bonis

University of Ferrara

Annunziato Mangiola

University of Chieti-Pescara

Marco Maria Fontanella

University of Brescia

Carmelo Anile

Università Cattolica del Sacro Cuore

Carlo Efisio Marras

Bambino Gesù Children's Hospital

Nicola Montano

Agostino Gemelli University Polyclinic

Paolo Frassanito

Istituti Clinici Scientifici Maugeri

G Sulsenti

Ospedale Maggiore

Angelo Pompucci

Ospedale Santa Maria Goretti

Cooperative Institutions

Istituti di Ricovero e Cura a Carattere Scientifico

Bambino Gesù Children's Hospital

Università Cattolica del Sacro Cuore

Agostino Gemelli University Polyclinic

Catholic University of America

Sapienza University of Rome

University of Rome Tor Vergata

University of Brescia

Boston Children's Hospital

University of Milan

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[THE FRONTAL EMISSARY CHANNEL. ANATOMO-RADIOLOGICAL AND CLINICAL CONSIDERATIONS ON 2 CASES].

PubMed (1963)

Elena Manara Carlotta Ginevra Nucci S Difede

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Citations (1)

[ON A CASE OF APPARENTLY PRIMARY MENINGIOMA OF THE FRONTAL SINUS].

PubMed (1963)

D Canciullo Carlotta Ginevra Nucci M Franzoni

Frontal sinus

Primary (astronomy)

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Citations (1)

The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the Down critical region

FEBS Letters (2000)

Francesco Acquati M. Accarino Carlotta Ginevra Nucci P. Fumagalli Luca Jovine

We applied cDNA selection methods to a genomic clone (YAC 761B5) from chromosome 21 located in the so‐called ‘Down critical region’ in 21q22.3. Starting from human fetal heart and brain mRNAs we obtained and sequenced several cDNA clones. One of these clones (Down region aspartic protease (DRAP), named also BACE2 according to the gene nomenclature) revealed a striking nucleotide and amino acid sequence identity with several motifs present in members of the aspartic protease family. In particular the amino acid sequences comprising the two catalytic sites found in all mammalian aspartic proteases are perfectly conserved. Interestingly, the predicted protein shows a typical membrane spanning region; this is at variance with most other known aspartic proteases, which are soluble molecules. We present preliminary evidence, on the basis of in vitro translation studies and cell transfection, that this gene encodes a glycosylated protein which localizes mainly intracellularly but to some extent also to the plasma membrane. Furthermore DRAP/BACE2 shares a high homology with a newly described β‐secretase enzyme (BACE‐1) which is a transmembrane aspartic protease. The implications of this finding for Down syndrome are discussed.

Aspartic acid

Homology

10.1016/s0014-5793(00)01192-3

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Citations (123)

Intraventricular Ectopic Cerebellum

World Neurosurgery (2020)

Alessandro De Benedictis Maria Camilla Rossi Espagnet Francesca Diomedi Camassei Sabrina Rossi Elena Fontana

Pia mater

Fourth ventricle

10.1016/j.wneu.2020.01.127

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Citations (3)

Three-Dimensional High-Definition Ventriculoscope: Single-Center Case Series

World Neurosurgery (2019)

Francesco Doglietto Francesco Belotti Carlotta Ginevra Nucci Elena Roca Pier Paolo Mattogno

Single Center

10.1016/j.wneu.2019.01.219

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Citations (5)

[Hematoma of the adrenal gland in the newborn infant. Clinical course. Presentation of 20 cases].

PubMed (1991)

M Baronti Fédérica De Paoli Carlotta Ginevra Nucci Riccardo Bientinesi M Palatinsky

The Authors stress the importance of a correct sonographic study in the follow-up of neonatal adrenal hemorrhage; the diagnostic conclusion are: the best criterion for differential diagnosis is the chronological variability. However the differential diagnosis is rather easy. The differential d. usually is against cystic-neuroblastoma, cortical renal cyst, adrenal abscess. They remark that laparatomy is unnecessary.

Presentation (obstetrics)

Adrenal Hemorrhage

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[ODONTOGENIC CYSTS OF THE SUPERIOR MAXILLA. OBSERVATION OF A CASE OF GIANT RADICULAR CYST].

PubMed (1963)

S Difede Carlotta Ginevra Nucci

Radicular Cyst

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Valutazione in vivo dei nervi ottici di pazienti glaucomatosi mediante Risonanza Magnetica con tensore di diffusione, confronto con gli indici del GDXvcc, dell’HRT3 e dell’OCT

Alessio Martucci Angelica Cerulli C Varesi Francesca Bolacchi Francesco Garaci

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Subacute Sclerosing Panencephalitis in Children: The Archetype of Non-Vaccination

Viruses (2022)

Laura Papetti Maria Elisa Amodeo Letizia Sabatini Melissa Baggieri Alessandro Capuano

Subacute sclerosing panencephalitis (SSPE) is a late complication of measles virus infection that occurs in previously healthy children. This disease has no specific cure and is associated with a high degree of disability and mortality. In recent years, there has been an increase in its incidence in relation to a reduction in vaccination adherence, accentuated by the COVID-19 pandemic. In this article, we take stock of the current evidence on SSPE and report our personal clinical experience. We emphasise that, to date, the only effective protection strategy against this disease is vaccination against the measles virus.

Subacute sclerosing panencephalitis

Pandemic

10.3390/v14040733

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Citations (16)

Peripheral Nerve Entrapment Syndromes of the Lower Extremity

Springer eBooks (2014)

Eduardo Fernández Carlotta Ginevra Nucci Corrado Lucantoni Liverana Lauretti Luca Denaro

Mononeuropathy

Entrapment

Entrapment Neuropathy

Sensation