Izarne Totorika

Biogipuzkoa Health Research Institute

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Jordi Rello

Centro de Investigación Biomédica en Red de Enfermedades Respiratorias

Ruth Salaberria

Osakidetza

Itziar Egibar

Osakidetza

Despoina Koulenti

University of Queensland

Yolanda Peña-López

The University of Texas Southwestern Medical Center

Naiara Etxeberria

Osakidetza

Amir Vahedian‐Azimi

Baqiyatallah University of Medical Sciences

Eneritz Gamboa

Osakidetza

Milagrosa Montes

Biogipuzkoa Health Research Institute

L. Bouadma

Hôpital Bichat-Claude-Bernard

Cooperative Institutions

Osakidetza

Centro de Investigación Biomédica en Red de Enfermedades Respiratorias

Biogipuzkoa Health Research Institute

Vall d'Hebron Hospital Universitari

Vall d'Hebron Institut de Recerca

Instituto de Salud Carlos III

European Society of Clinical Microbiology and Infectious Diseases

Sağlık Bilimleri Üniversitesi

Universitat Autònoma de Barcelona

University of the Basque Country

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Cerebral oximetry vs capnography to monitor chest compressions and return of spontaneous circulation in out-of-hospital cardiac arrest

Resuscitation (2019)

Ruth Salaberria Andima Larrea Leyre Amas Daniel Alonso Naiara Etxeberria

Capnography

10.1016/j.resuscitation.2019.06.213

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Assessing predictive accuracy for outcomes of ventilator-associated events in an international cohort: the EUVAE study

Intensive Care Medicine (2018)

S Ramirez Leonel Lagunes Yolanda Peña-López Amir Vahedian‐Azimi Saad Nseir

Pain medicine

10.1007/s00134-018-5269-7

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Human metapneumovirus as cause of severe community-acquired pneumonia in adults: insights from a ten-year molecular and epidemiological analysis

Annals of Intensive Care (2019)

Loreto Vidaur Izarne Totorika Milagrosa Montes Diego Vicente Jordi Rello

Information on the clinical, epidemiological and molecular characterization of human metapneumovirus in critically ill adult patients with severe community-acquired pneumonia (CAP) and the role of biomarkers identifying bacterial coinfection is scarce.This is a retrospective epidemiological study of adult patients with hMPV severe CAP admitted to ICU during a ten-year period with admission PSI score ≥ 3.The 92.8% of the 28 patients with severe CAP due to human metapneumovirus were detected during the first half of the year. Median age was 62 years and 60.7% were male. The genotyping of isolated human metapneumovirus showed group B predominance (60.7%). All patients had acute respiratory failure. Median APACHE II and SOFA score were 13 and 6.55, respectively. The 25% were coinfected with Streptococcus pneumoniae. 60.7% of the patients had shock at admission and 50% underwent mechanical ventilation. Seven patients developed ARDS, three of them younger than 60 years and without comorbidities. Mortality in ICU was 14.3%. Among survivors, ICU and hospital stay were 6.5 and 14 days, respectively. Plasma levels of procalcitonin were higher in patients with bacterial coinfection (18.2 vs 0.54; p < 0.05). The levels of C-reactive protein, however, were similar.Human metapneumovirus was associated with severe CAP requiring ICU admission among elderly patients or patients with comorbidities, but also in healthy young subjects. These patients often underwent mechanical ventilation with elevated health resource consumption. While one out of four patients showed pneumococcal coinfection, plasma procalcitonin helped to implement antimicrobial stewardship.

Procalcitonin

10.1186/s13613-019-0559-y

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Citations (30)