Meiling Zheng

Chinese Academy of Medical Sciences & Peking Union Medical College

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Ming Zhao

Central South University

Zhi Hu

Chinese Academy of Medical Sciences & Peking Union Medical College

Qianjin Lu

Second Xiangya Hospital of Central South University

Xiaoli Min

Chinese Academy of Medical Sciences & Peking Union Medical College

Shuang Lu

Central South University

Wenhui Zhou

Second Xiangya Hospital of Central South University

Qianjin Lu

Chinese Academy of Medical Sciences & Peking Union Medical College

Md. Asaduzzaman Khan

North South University

Junjiang Fu

Southwest Medical University

Lianlian Ouyang

Central South University

Cooperative Institutions

Central South University

Chinese Academy of Medical Sciences & Peking Union Medical College

Second Xiangya Hospital of Central South University

Crown Bioscience (China)

Chinese Academy of Medical Sciences Dermatology Hospital

Chinese Academy of Sciences

Peking University

Southwest Medical University

Xiangya Hospital Central South University

Qingdao National Laboratory for Marine Science and Technology

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The deacetylase sirtuin 6 protects against kidney fibrosis by epigenetically blocking β-catenin target gene expression

Kidney International (2019)

Juan Cai Zhiwen Liu Xian Huang Shaoqun Shu Xiaoru Hu

SIRT6

Sirtuin 1

Histone deacetylase 2

HDAC1

Histone deacetylase inhibitor

10.1016/j.kint.2019.08.028

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Citations (65)

RFX1 regulates foam cell formation and atherosclerosis by mediating CD36 expression

International Immunopharmacology (2024)

Shuang Yang Xiaoli Min Longyuan Hu Meiling Zheng Shuang Lu

CD36

Foam cell

Pathogenesis

10.1016/j.intimp.2024.111751

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Citations (1)

Preclinical pharmacology modeling of chimeric antigen receptor T therapies

Current Opinion in Pharmacology (2021)

Rajendra Kumari Xuesong Ouyang Jingjing Wang Xiaoxi Xu Meiling Zheng

Cytokine Release Syndrome

10.1016/j.coph.2021.08.008

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Citations (14)

Natural Product Cordycepin (CD) Inhibition for NRP1/CD304 Expression and Possibly SARS-CoV-2 Susceptibility Prevention on Cancers

Microorganisms (2023)

Ting Li Na Luo Jiewen Fu Jiaman Du Zhiying Liu

NRP1/CD304 is a typical membrane-bound co-receptor for the vascular endothelial cell growth factor (VEGF), semaphorin family members, and viral SARS-CoV-2. Cordycepin (CD) is a natural product or active gradient from traditional Chinese medicine (TCM) from Cordyceps militaris Link and Ophiocordyceps sinensis (Berk.). However, NRP1 expression regulation via CD in cancers and the potential roles and mechanisms of SARS-CoV-2 infection are not clear. In this study, online databases were analyzed, Western blotting and quantitative RT-PCR were used for NRP1 expression change via CD, molecular docking was used for NRP/CD interaction, and a syncytial formation assay was used for CD inhibition using a pseudovirus SARS-CoV-2 entry. As a result, we revealed that CD inhibits NRP1 expressed in cancer cells and prevents viral syncytial formation in 293T-hACE2 cells, implying the therapeutic potential for both anti-cancer and anti-viruses, including anti-SARS-CoV-2. We further found significant associations between NRP1 expressions and the tumor-immune response in immune lymphocytes, chemokines, receptors, immunostimulators, immune inhibitors, and major histocompatibility complexes in most cancer types, implying NRP1's roles in both anti-cancer and anti-SARS-CoV-2 entry likely via immunotherapy. Importantly, CD also downregulated the expression of NRP1 from lymphocytes in mice and downregulated the expression of A2AR from the lung cancer cell line H1975 when treated with CD, implying the NRP1 mechanism probably through immuno-response pathways. Thus, CD may be a therapeutic component for anti-cancer and anti-viral diseases, including COVID-19, by targeting NRP1 at least.

Cordycepin

10.3390/microorganisms11122953

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Citations (4)

Effects of different periods of pelvic floor muscle exercise on the recovery of vaginal delivery of maternal pelvic floor muscle function

China Modern Doctor (2013)

Meiling Zheng

Objective To investigate the effect about pelvic floor muscle exercises in different periods on pelvic floor muscle function recovery vaginal delivery in pregnant women.Methods We selceted 156 cases of normal pregnant women,they were randomly divided into prenatal group(n = 50),who done pelvic floor muscle exercises from 28 pregnancy weeks to delivering;postpartum group(n = 52) who done pelvic floor muscle exercises from postpartum third to postpartum 3 months;whole group(n = 54) who done pelvic floor muscle exercises from 28 pregnancy weeks to post partum 3 months.control group(n = 55) who didn’t pelvic floor muscle exercises.prenatal,postpartum 3 months pelvic floor muscle tension of the four groups were comparativly analysised.Results After antenatal pelvic floor muscle exercises,the vaginal contraction time,VRP,VSP of prenatal group and whole group were improved significantly than postnatal group and control group(P 0.05).After pelvic floor muscle exercises,the maternal vaginal contraction time of whole group was significantly longer than the other 3 groups,VRP,VSP was higher than the other 3 groups(P 0.05);the vaginal contraction time of prenatal group and postpartum group,VRP,VSP had no significant difference(P 0.05),but were significantly higher than those in control group(P 0.05).Conclusion Maternal early do pelvic floor muscle exercises and continue to postpartum 3 months can maximally maintain and restore pelvic floor muscle function recov ery,it is worthy of clinical application.

Pelvic Floor Muscle

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Regulatory factor X1 induces macrophage M1 polarization by promoting DNA demethylation in autoimmune inflammation

JCI Insight (2023)

Shuang Yang Du Haobo Cui Meiling Zheng Wei He

Abnormal macrophage polarization is generally present in autoimmune diseases. Overwhelming M1 macrophage activation promotes the continuous progression of inflammation, which is one of the reasons for the development of autoimmune diseases. However, the underlying mechanism is still unclear. Here we explore the function of Regulatory factor X1 (RFX1) in macrophage polarization by constructing colitis and lupus-like mouse models. Both in vivo and in vitro experiments confirmed that RFX1 can promote M1 and inhibit M2 macrophage polarization. Furthermore, we found that RFX1 promoted DNA demethylation of macrophage polarization-related genes by increasing APOBEC3A/Apobec3 expression. We identified a potential RFX1 inhibitor, adenosine diphosphate (ADP), providing a potential strategy for treating autoimmune diseases.

Macrophage polarization

M2 Macrophage

10.1172/jci.insight.165546

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Citations (1)

Relationship between the variations of centromere protein and aneuploid

Chinese Journal of Birth Health & Heredity (2013)

Meiling Zheng

Objectives: In order to explore the relation between embryos of aneuploid occurrence and their parents,this paper investigated the variations of CENPs of them.Methods: there are two groups,the test group are chromosome of aneuploid embryos which were been diagnosed had stopped growth and the chromosome of their parents,the compare group are the embryos which are chromosome of normal and the chromosome of their parents,The peripheral blood lymphocyte chromosome specimens were made with the routine chromosomal technique,G-band were developed.useing the technique of immunhitehmisty to get the CENPs.all the cases have whole data of G-band technique.Results : ① The rate of aneuploid chorion chromosome in study group was 44.78%,Among 30 cases with karyotype disorder,12 cases of sex chromosome take 40.00% of the cases.7 cases of 21-trisomy syndrome take 23.33% of the cases.②The test group and the compare group chromosome both have CENPS.And the CENPS of the test group was much lower than the compare group.t = 3.012 P 0.05).the CENPS of the test group was much lower then their paternal group(t = 4.279 P 0.001),No significant difference between the test group and their maternal group.(t = 1.927 P 0.05);The CENPS of the compare group was much lower then their paternal group(t = 3.008 P 0.05),No significant difference between the test group and their maternal group.(t = 1.234 P 0.05).Conclusions: Less CENPS are closely related to aneuploid occurrence,and contents of CENPS may come from the maternal group,in order to offer evidences of the genetics between descendants and their mothers

Trisomy

Group B

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Intratumor microbiome-derived butyrate promotes lung cancer metastasis

Cell Reports Medicine (2024)

Yi Ma Haiming Chen Haoran Li Meiling Zheng Xianglin Zuo

Most recurrences of lung cancer (LC) occur within 3 years after surgery, but the underlying mechanism remains unclear. Here, we collect LC tissues with shorter (<3 years, recurrence group) and longer (>3 years, non-recurrence group) recurrence-free survival. By using 16S sequencing, we find that intratumor microbiome diversity is lower in the recurrence group and butyrate-producing bacteria are enriched in the recurrence group. The intratumor microbiome signature and circulating microbiome DNA can accurately predict LC recurrence. We prove that intratumor injection of butyrate-producing bacteria Roseburia can promote subcutaneous tumor growth. Mechanistically, bacteria-derived butyrate promotes LC metastasis by increasing expression of H19 in tumor cells through inhibiting HDAC2 and increasing H3K27 acetylation at the H19 promoter and inducing M2 macrophage polarization. Depletion of macrophages partially abolishes the metastasis-promoting effect of butyrate. Our results provide evidence for the cross-talk between the intratumor microbiome and LC metastasis and suggest the potential prognostic and therapeutic value of the intratumor microbiome.

10.1016/j.xcrm.2024.101488

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Citations (20)

Self-Healing Optimization of Power Grid under High Penetration of New Energy

Zelong Jin Bohan Yang Xiangyu Kong Meiling Zheng Jiancun Liu

Penetration (warfare)

Power grid

10.1109/ccssta62096.2024.10691803

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Recent Advances for Dynamic-Based Therapy of Atherosclerosis

International Journal of Nanomedicine (2023)

Guanghao Wu Guanye Yu Meiling Zheng Wenhui Peng Lei Li

Abstract: Atherosclerosis (AS) is a chronic inflammatory disease, which may lead to high morbidity and mortality. Currently, the clinical treatment strategy for AS is administering drugs and performing surgery. However, advanced therapy strategies are urgently required because of the deficient therapeutic effects of current managements. Increased number of energy conversion-based organic or inorganic materials has been used in cancer and other major disease treatments, bringing hope to patients with the development of nanomedicine and materials. These treatment strategies employ specific nanomaterials with specific own physiochemical properties (external stimuli: light or ultrasound) to promote foam cell apoptosis and cholesterol efflux. Based on the pathological characteristics of vulnerable plaques, energy conversion-based nano-therapy has attracted increasing attention in the field of anti-atherosclerosis. Therefore, this review focuses on recent advances in energy conversion-based treatments. In addition to summarizing the therapeutic effects of various techniques, the regulated pathological processes are highlighted. Finally, the challenges and prospects for further development of dynamic treatment for AS are discussed. Keywords: atherosclerosis, nanomaterial, physiochemical, reactive oxygen species, energy conversion, therapy

Disease treatment

Cancer Therapy

10.2147/ijn.s402678

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Citations (4)