Nayelli Arguelles-Morales

Instituto Nacional de Neurología y Neurocirugía

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Antonio Araúz

Instituto Nacional de Neurología y Neurocirugía

Angélica Ruíz-Franco

Hospital Juárez de México

Juan Camilo Vargas‐González

University of Toronto

Alejandro Quiroz-Compeán

Instituto Nacional de Cancerología

Humberto Silos

Instituto Nacional de Neurología y Neurocirugía

Aleida Cecilia Quiroz Rivera

Lakeland Regional Medical Center

Agnès Fleury

Instituto Nacional de Neurología y Neurocirugía

Francisco Ruiz-Navarro

Kepler Universitätsklinikum

Miguel A. Barboza

Ministerio de Agricultura y Ganadería de Costa Rica

M. Reyes

Universidad Cuauhtémoc

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Instituto Nacional de Neurología y Neurocirugía

Universidad Nacional Autónoma de México

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

Asociación Mexicana de Psicología y Desarrollo Comunitario

National Institute of Genomic Medicine

Instituto de Medicina Genómica

National Legal Medicine Institute

University of California, Los Angeles

Lakeland Regional Medical Center

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Abstract T MP82: Time to Recanalization after Cerebral Venous Thrombosis

Stroke (2014)

Nayelli Arguelles-Morales Juan Camilo Vargas‐González Angélica Ruíz-Franco Alejandro Quiroz-Compeán Antonio Araúz

Background and Purpose: Cerebral venous thrombosis (CVT) comprises around 0.5% of strokes. Early initiation of anticoagulants, is safe and ensues a better functional prognosis. Different studies have addressed the issue, the rate and moment of recanalization has not been sufficiently defined, and it may have relevancy regarding treatment decisions. Our purpose was to estimate the time to recanalization of adults with acute CVT at one year follow-up. Methods: We prospectively studied a group of patients with confirmed diagnoses of CVT. Neuroimaging and clinical follow-up were performed at 3, 6, 9 and 12 months. All patients were treated with oral anticoagulant for 12 months or until complete recanalization. Statistical analysis used Kaplan-Meier method for survival tables. Results: We included 101 patients; median age was 33.6+11, women 79 (78.2%); 99 (98.0%) were evaluated and follow-up with MR venography. Complete recanalization at one year was accomplished in 65 (64.4%), partial in 29 (28.7%) and no recanalization in 7 (6.9%). We found that the proportion of any recanalization at 3 months was 65.3±4.7%, 6 months 89.1±3.1%, 9 months 91.5%±2.8% and 12 months 93.9%±6.1%. Complete recanalization at 3 months was 27.7±4.5%, 6 months 55.6±5.0%, 9 months 63.2%±5.0% and 12 months 68.5%±4.9%. Conclusions: Our result displays that at least partial recanalization in CVT occurs mainly within the first 6 months. However, there is a significant proportion of patients that achieve complete recanalization until 9 months of treatment regardless of the site of occlusion.

Venography

Stroke

10.1161/str.45.suppl_1.tmp82

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Clinical Spectrum of Artery of Percheron Infarct: Clinical–Radiological Correlations

Journal of Stroke and Cerebrovascular Diseases (2013)

Antonio Araúz Hernán Mauricio Patiño-Rodríguez Juan Camilo Vargas‐González Nayelli Arguelles-Morales Humberto Silos

Posterior cerebral artery

Anterior cerebral artery

10.1016/j.jstrokecerebrovasdis.2013.09.011

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Citations (128)

Response to Letter: Aneurysm, ischemic stroke and cysticercosis

Clinical Neurology and Neurosurgery (2014)

Antonio Araúz Francisco Ruiz-Navarro Humberto Silos Juan Camilo Vargas‐González Nayelli Arguelles-Morales

Stroke

10.1016/j.clineuro.2013.12.025

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TGFBR2 mutation and MTHFR-C677T polymorphism in a Mexican mestizo population with cervico-cerebral artery dissection

Journal of Neurology (2016)

Angélica Ruíz-Franco Miguel A. Barboza Aurelio Jara‐Prado Samuel Canizales‐Quinteros Paola León‐Mimila

10.1007/s00415-016-8101-8

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Time to recanalisation in patients with cerebral venous thrombosis under anticoagulation therapy

Journal of Neurology Neurosurgery & Psychiatry (2015)

Antonio Araúz Juan Camilo Vargas‐González Nayelli Arguelles-Morales Miguel A. Barboza Juan Manuel Calleja

Few studies have investigated the rates of recanalisation after cerebral venous thrombosis (CVT). Our objective was to investigate the recanalisation rate and to identify predictors of recanalisation in patients with CVT.We included 102 patients with confirmed first-ever, non-septic CVT. All patients received anticoagulation for 12 months or until complete recanalisation. To assess recanalisation, patients underwent MR venography every 3 months until partial or complete recanalisation or for 12 months after diagnosis. We conducted two parallel analyses of complete recanalisation versus partial and no recanalisation versus any recanalisation. As a secondary objective we explored the influence of recanalisation on outcome and recurrent events. We calculated the probability of recanalisation using Kaplan-Meier analysis and conducted multivariate analysis using a Cox model.The mean age of patients was 33.5±11 years (80 (78.4%) women). Survival analysis indicated that 50% of the patients had any recanalisation (grades I, II and III) by 64 days and complete recanalisation (grade III) by 169 days. Adjusted Cox proportional model revealed that age <50 years (HR=11.5 95% CI=1.58 to 84.46, p=0.01) and isolated superior sagittal sinus thrombosis (HR=0.39, 95% CI=0.14 to 1.04, p=0.05) predict complete recanalisation, while age <50 years (HR=4.79; 95% CI=1.69 to 13.5, p=0.003) predicts any recanalisation. Patients with complete recanalisation had a greater chance of good functional outcome (HR=5.17; 95% CI=2.8 to 9.53, p<0.001).We found that recanalisation occurs over time, until month 11. Complete recanalisation may influence functional outcome.

10.1136/jnnp-2014-310068

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Citations (66)

Concurrent asymptomatic inflammatory aneurysm and ischemic stroke due to cysticercal arteritis

Clinical Neurology and Neurosurgery (2013)

Antonio Araúz Francisco Ruiz-Navarro Humberto Silos Juan Camilo Vargas‐González Nayelli Arguelles-Morales

Stroke

10.1016/j.clineuro.2013.10.001

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Citations (13)