Ramji Lal Yadav

Mankind Pharma (India)

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Shrinarayan Karaiya

Mankind Pharma (India)

Virendra K. Arya

Post Graduate Institute of Medical Education and Research

Rajeev Jain

Pondicherry University

Rahul Dev

Mankind Pharma (India)

Rajiv Roy

Calcutta National Medical College and Hospital

Ruchita Santra

Delhi Pharmaceutical Science and Research University

Rajeev Kumar

Government of India

Neeru Singh

National Institute for Research in Tribal Health

Ritesh Mishra

Indian Institute of Technology Jodhpur

S. N. Pandeya

Dr. K.N.Modi University

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Dr. K.N.Modi University

Mankind Pharma (India)

Jiwaji University

Swami Vivekanand Subharti University

Delhi Pharmaceutical Science and Research University

Post Graduate Institute of Medical Education and Research

Birla Institute of Technology and Science, Pilani

Creative Commons

Calcutta National Medical College and Hospital

Medical College and Hospital, Kolkata

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1,2,4-Triazine Analogs as Novel Class of Therapeutic Agents

Mini-Reviews in Medicinal Chemistry (2014)

Rajeev Kumar T.S. Sirohi Hariram Singh Ramji Lal Yadav Rajiv Roy

1,2,4-Triazine nucleus is a prominent structural core system present in numerous pharmacologically active compounds. Till date, various 1,2,4-triazine analogs, possesing a wide range of potent pharmacological activities, have been reported. This review is an attempt to compile the medicinal chemistry aspects of various synthesized 1,2,4-triazine analogs reported so far. Keywords: Anticancer activity, anticonvulsant activity, antimicrobial activity, 1, 2, 4-triazine.

Triazine

1,3,5-Triazine

10.2174/1389557514666140131111837

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Stability Indicating Method for the Assay of Remogliflozin Etabonate and its Related Substances by RP-HPLC

Analytical Chemistry Letters (2023)

Ramji Lal Yadav Rahul Dev Ruchita Santra Priti Jain

Simple, accurate, precise and stable indicating HPLC methods were developed and validated to determine both related substances and the assay content of Remogliflozin etabonate (RME). The separation was established under optimized chromatographic condition using Waters e2695 HPLC coupled to Ultraviolet detector (UV) at 228 nm with Inertsil ODS-3V C18 column (250 mm x 4.6 mm, 5 μm), injection volume 10 μl for related substances and 20 μl for assay content determination. The mobile phase consisted of 10 mM KH2PO4 buffer with ortho-phosphoric acid pH 2.5. Gradient elution was maintained at a flow rate of 1.0 ml/min using 45°C column oven temperature for determination of the related substances and isocratic elution was maintained at a flow rate of 1.2 ml/min for assay content. The retention time for RME-01, RME-02, RME-03 and RME-04, RME-05 and RME were about 41.74 min, 11.42 min, 20.38 min, 37.16 min, 49.93 min, 25.05 min respectively. The linearity was found to be in the concentration range of 0.312-2.341 μg/ mL for RME-01, 0.306-2.292 μg/ mL for RME-02, 0.306-2.297 μg/ ml for RME-03 and 0.294-2.203 μg/mL for RME-04. The RME was subjected to acid, base, oxidation, and thermal degradation stress conditions. The method was validated according to the ICH guidelines for specificity, precision, linearity, accuracy and robustness and the values were found to be within the limits.

Phosphoric acid

10.1080/22297928.2023.2176785

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Synthesis and electrochemical behaviour of 2-[4'-(substituted)sulphonamoylphenyl]hydrazono ethyl-2-cyanoethanoate

Rajeev Jain Ramji Lal Yadav Shrinarayan Karaiya Virendra K. Arya

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Characterization of 2-Deoxy-D-glucose

BENTHAM SCIENCE PUBLISHERS eBooks (2024)

Ramji Lal Yadav Neeru Singh Shrinarayan Karaiya Rahul Dev Anil Kumar

2-Deoxy-D-glucose is an important pharmaceutical intermediate, and its analytical characterization is critical for establishing its purity and quality. This chapter summarizes spectroscopic techniques, including UV, IR, NMR, and mass spectrometry, along with HPLC and GC studies used for the complete structural elucidation and purity analysis of 2-Deoxy-D-glucose. The UV spectrum of 2-DeoxyD-Glucose showed no distinct peaks. The IR spectrum displayed characteristic bands for the O-H and C-H functional groups. 1H, 13C, APT, DEPT NMR, HSQC, and HMBC experiments confirmed the nominally proposed structure. ESI-MS revealed an [M+Na]+ ion at m/z 187. Specific optical rotation was measured in water. HPLC studies estimated the related substances and assay to be 1.2% and 99.8%, on an anhydrous basis, respectively. The residual solvents, such as methanol, isopropyl alcohol, ethyl acetate, and toluene, were determined by GC headspace and found to be within the limits. The collective analytical evidence confirmed that the test sample met the quality specifications for 2-Deoxy-D-glucose.

Characterization

10.2174/9789815305159124010006

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Synthesis and electrochemical behaviour of 3-(4'-(substituted) sulphonamoylphenyl) azomethine indoles

Rajeev Jain Shrinarayan Karaiya Ramji Lal Yadav Virendra K. Arya

This study presents synthesis of 3-[4'-(substituted) sulphonamoylphenyl] azomethine indoles (SPAI) by refluxing indole3-carboxaldehyde with sulfonamide derivatives. Electrochemical behaviour of SPAI was studied in Britton-Robinson (BR) buffer solution (pH 2.5-12.0) at dropping mercury electrode (DME) and glassy carbon electrode (GCE). Cathodic differential pulse polarographic peak was obtained at DME in pH range 2.5-6.5. Cyclic voltammogram exhibited a well defined, irreversible cathodic and anodic peak at GCE. At pH 6.5 and above, reduction peak exhibited a tendency to split into two peaks, indicating that 1H + /2e reduction of 2-[4’-sulphonamoylphenyl]hydrazono-1,3-indanediones occurs in one 1H + and one 2e steps. A product of CPE was characterized by elemental and spectral analyses.

Polarography

Sulfonamide

Glassy carbon

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Synthesis and Electrochemical study of 1-[2′, 4′-dinitrophenyl)-3, 5-dimethyl-4-[4′′-(Substituted)sulphonamoylphenyl] azopyrazoles

Research & Reviews A Journal of Drug Formulation Development and Production (2014)

Shrinarayan Karaiya Ritesh Mishra Ramji Lal Yadav Virendra K. Arya Hitesh Malvia

Electrochemical behavior of 1-(2',4'-dinitrophenyl)-3,5-dimethyl-4-[4-substituted) sulphonamoylphenyl] azopyrazole (DDSPA) was studied in Britton-Robinson (BR) buffer range of pH 3.5–12 at dropping mercury electrode (DME) and glassy carbon electrode (GCE). Cathodic differential pulse polarographic peak is obtained at DME in the pH range 3.5–12. Cyclic voltammogram exhibited a well-defined, irreversible cathodic and anodic peak at GCE. At pH 3.5–12, the reduction peak exhibited a tendency to split into two peaks. The first 8e - peak has been assigned to the reduction of two nitro groups to hydroxylamine group and second 2e - peak has been assigned to the reduction of azo group to hydrazono group (-NH-NH-). A product of controlled potential electrolysis (CPE) was characterized by elemental and spectral analysis. Keywords: a zopyrazoles, polarography, voltammetry, CPE, electrochemistry

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Hydroxylamine

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