Nina Dmitrieva

Immanuel Kant Baltic Federal University

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Balveen Kaur

Augusta University Health

E. Antonio Chiocca

Neurological Surgery

Sean E. Lawler

Brown University

Ralph Weissleder

Center for Systems Biology

Davide Gianni

AstraZeneca (United Kingdom)

Robert L. Martuza

Massachusetts General Hospital

Anat Stemmer Rachamimov

Massachusetts General Hospital

Nico van Rooijen

Vrije Universiteit Amsterdam

Daniel J. Brat

Northwestern University

Elisabeth J. Fontana

Massachusetts General Hospital

Cooperative Institutions

The Ohio State University

The Ohio State University Wexner Medical Center

Neurological Surgery

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute

University of Turin

University of Bologna

Harvard University

Massachusetts General Hospital

Ryazan State Medical University named after Academician I.P. Pavlov

AHEPA University Hospital

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Positivismus und Marburger Neukantianismus: Die unterschiedlichen Wissenschaftsideen

Nina Dmitrieva

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The Kantian origins of Sergei Rubinstein's theory of moral improvement

Journal of Philosophy of Education (2021)

Nina Dmitrieva

The early and late texts of the Russian psychologist and philosopher Sergei Rubinstein focus on ethical issues. The unfinished and fragmentary nature of these texts has contributed to the limited exploration of the ideas they contain. Rubinstein's main concern was the possibility of human moral improvement, a concern that originated in the young Rubinstein's study of the philosophies of Kant and Hegel, and somewhat later, the early manuscripts of Marx. In this paper, I show the pivotal importance of Kantian ethics for Rubinstein's theory of moral improvement. By criticising Kant's doctrine of the intelligible character of the human being, Rubinstein revises the relation between subjects and their deeds and shows that, in this relation, subjects not only express but also determine themselves. On the same basis, Rubinstein formulates the principle of creative self-activity, which he proposes to place at the foundation of a renewed 'Socratic–Platonist pedagogy' that can reveal the intersubjective nature of self-consciousness and will. In his critique of Kant, Rubinstein relies, to a large extent, on interpretations offered by Cohen, Natorp and Rickert. Rubinstein also attempts to solve Kant's problem of the dual nature of the human being, and in justifying the need to reconcile duty and inclination, he follows the same critical path as Schiller. Adducing the categorical imperative in its 'formula of humanity', and the principle of human self-determination through action, Rubinstein places the concept of educating behaviour at the core of his theory of moral improvement.

Categorical imperative

Foundation (evidence)

10.1111/1467-9752.12632

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Citations (22)

Identification of cholinoceptive glycinergic neurons in the mammalian retina

The Journal of Comparative Neurology (2002)

Nina Dmitrieva David V. Pow Jon Lindstrom Kent T. Keyser

The light-evoked release of acetylcholine (ACh) affects the responses of many retinal ganglion cells, in part via nicotinic acetylcholine receptors (nAChRs). nAChRs that contain beta2alpha3 neuronal nicotinic acetylcholine receptors have been identified and localized in the rabbit retina; these nAChRs are recognized by the monoclonal antibody mAb210. We have examined the expression of beta2alpha3 nAChRs by glycinergic amacrine cells in the rabbit retina and have identified different subpopulations of nicotinic cholinoceptive glycinergic cells using double and triple immunohistochemistry with quantitative analysis. Here we demonstrate that about 70% of the cholinoceptive amacrine cells in rabbit retina are glycinergic cells. At least three nonoverlapping subpopulations of mAb210 glycine-immunoreactive cells can be distinguished with antibodies against calretinin, calbindin, and gamma-aminobutyric acid (GABA)(A) receptors. The cholinergic cells in rabbit retina are thought to synapse only on other cholinergic cells and ganglion cells. Thus, the expression of beta2alpha3 nAChRs on diverse populations of glycinergic cells is puzzling. To explore this finding, the subcellular localization of beta2alpha3 was studied at the electron microscopic level. mAb210 immunoreactivity was localized on the dendrites of amacrines and ganglion cells throughout the inner plexiform layer, and much of the labeling was not associated with recognizable synapses. Thus, our findings indicate that ACh in the mammalian retina may modulate glycinergic circuits via extrasynaptic beta2alpha3 nAChRs.

Inner plexiform layer

Amacrine cell

Retinal waves

10.1002/cne.10520

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Citations (20)

Preface

SHS Web of Conferences (2023)

Nina Dmitrieva Robert Hanna Vadim Chaly

10.1051/shsconf/202316100001

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Effects of the destruction of starburst-cholinergic amacrine cells by the toxin AF64A on rabbit retinal directional selectivity

Visual Neuroscience (2002)

Franklin R. Amthor Kent T. Keyser Nina Dmitrieva

The effects of intraocular injections of ethylcholine mustard aziridinium ion (AF64A), an irreversible inhibitor of choline uptake, on the rabbit retina were assessed electrophysiologically, pharmacologically, anatomically, and behaviorally. Survival times from 1 day to 30 days were investigated. After 24 h, the shortest time tested, the directional selectivity of On–Off responding ganglion cells having the characteristic morphology of On–Off directionally selective directionally selective (DS) ganglion cells, as revealed by intracellular dye injection, was significantly reduced, both by an apparent decrease of preferred direction responses and an increase in responses to null-direction movement. No toxin-mediated changes in the dendritic trees of these cells were noted. Cells in AF64A-affected retinas having the DS morphology did not respond significantly to GABAergic or cholinergic agents such as picrotoxin and eserine, but did respond to nicotine. Recordings from a small random sample of other ganglion cell classes in the same retinas yielded no obvious changes in response properties. The direct effects on starburst (cholinergic) amacrine cells, which were identified by intraocular injection of the fluorescent dye DAPI with the AF64A, were investigated by intracellular injections of Lucifer yellow, and by immunohistochemical staining with antibodies to choline acetyltransferase (ChAT). Although starburst amacrine cell somas survived the AF64A treatment for at least several days, the dendrites could not be visualized by fluorescent dye injection in affected retinas due to dye leakage of the injected fluorescent dye from either the soma or proximal dendritic region. ChAT staining revealed a sequence in which ChAT-positive cells were undetectable first in the inner nuclear layer, and then in the ganglion cell layer. Cholinergic amacrine cells in the central retina were also affected before those in the periphery. The electrophysiological changes observed typically preceded the loss of ChAT activity. Behavioral tests for optokinetic nystagmus responses also revealed a lack of such responses in the affected eyes.

Tetrodotoxin

10.1017/s0952523802194119

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Citations (97)

The Revamped Kantovsky Sbornik

Nina Dmitrieva

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Hotel management

Nina Dmitrieva Nataliya Zayceva Светлана Огнева

Examines the development and modern concepts of hotel management — system, process and situational approaches. Describes the features of hospitality management related to the organization of the network business, using franchising and management companies. Given numerous examples from the practice of Russian and foreign enterprises of hotel business. Meets the requirements of Federal state educational standards of higher education of the last generation. For students enrolled in the specialty "Hospitality", as well as graduate students, professors from specialized higher education institutions, listeners of professional retraining programs of employees of the enterprises of hotel business.

Retraining

Situational ethics

Hospitality

Hospitality management studies

Hotel management

10.12737/978913

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2007.03.036. СИСТЕМНАЯ ФИЛОСОФИЯ КАК САМОПОЗНАНИЕ: ГЕГЕЛЬ И НЕОКАНТИАНСТВО. SYSTEMPHILOSOPHIE ALS SELBSTERKENNTNIS: HEGEL UND DER NEUKANTIANISMUS / HRSG. VON FULDA H.F., KRIJNEN CH. - WüRZBURG: KöNIGSHAUSEN & NEUMANN, 2006. - 178 S. - (STUDIEN ZUM SYSTEM DER PHILOSOPHIE; BD. 7)

Социальные и гуманитарные науки. Отечественная и зарубежная литература. Сер. 3, Философия: Реферативный журнал (2007)

Nina Dmitrieva

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Expression of Alpha 7 Nicotinic Acetylcholine Receptors by Bipolar, Amacrine, and Ganglion Cells of the Rabbit Retina

Journal of Histochemistry & Cytochemistry (2006)

Nina Dmitrieva Christianne E. Strang Kent T. Keyser

Cholinergic agents affect the light responses of many ganglion cells (GCs) in the mammalian retina by activating nicotinic acetylcholine receptors (nAChRs). Whereas retinal neurons that express beta2 subunit-containing nAChRs have been characterized in the rabbit retina, expression patterns of other nAChR subtypes remain unclear. Therefore, we evaluated the expression of alpha7 nAChRs in retinal neurons by means of single-, double-, and triple-label immunohistochemistry. Our data demonstrate that, in the rabbit retina, several types of bipolar cells, amacrine cells, and cells in the GC layer express alpha7 nAChRs. At least three different populations of cone bipolar cells exhibited alpha7 labeling, whereas glycine-immunoreactive amacrine cells comprised the majority of alpha7-positive amacrine cells. Some GABAergic amacrine cells also displayed alpha7 immunoreactivity; alpha7 labeling was never detected in rod bipolar cells or rod amacrine cells (AII amacrine cells). Our data suggest that activation of alpha7 nAChRs by acetylcholine (ACh) or choline may affect glutamate release from several types of cone bipolar cells, modulating GC responses. ACh-induced excitation of inhibitory amacrine cells might cause either inhibition or disinhibition of other amacrine and GC circuits. Finally, ACh may act on alpha7 nAChRs expressed by GCs themselves.

Amacrine cell

Retinal waves

Inner plexiform layer

10.1369/jhc.6a7116.2006

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Citations (50)

Вокруг «Социальной педагогики» Пауля Наторпа: В. Ф. Динзе в полемике о национальном воспитании. Часть 1

Kantian journal (2016)

Nina Dmitrieva

10.5922/0207-6918-2016-4-3

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