The production of space is one of the mainstream theories in the west and gradually becoming the effective tools to explain the city space development in China. This passage analyses the interests of the three game players of ChuHe Han street,include government,developers and public. Then this text analyses the problems of ChuHe Han street,include the crisis of spatial characteristics,space justice and humanistic. The main cause of this problems is the structural imbalance of group game. Finally,the article draws conclusions: equilibrium of the game is important to ensure city space production development healthy. The specific measures include prevent the unlimited expansion of capital,transformate role of government and improve the mechanism of public participation. The most important measure is accurating positioning of government. So government should represent the benefit of public.
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MicroRNAs (miRNAs) play a prominent role in gastric cancer (GC) initiation and progression. In this study, we found that miR‐374a expression was up‐regulated in human GC cell lines and tissues. Inhibition of miR‐374a suppressed GC cell proliferation, migration and invasion in vitro and slowed tumor growth in vivo. SRC kinase signaling inhibitor 1 (SRCIN1) was identified as a direct target of miR‐374a. Silencing of SRCIN1 significantly enhanced cell proliferation, migration and invasion, whereas SRCIN1 reintroduction partially abrogated the oncogenic effects of miR‐374a. Taken together, these findings suggest that miR‐374a functions as a candidate oncogene in GC by directly targeting SRCIN1. miR‐374a may therefore be useful as a promising therapeutic target for malignant GC.
Abstract Background Diversion colitis (DC) DC is nonspecific inflammation of the distal intestinal mucosa following disruption of colonic continuity with colonic dysfunction. With the gradual prolongation time of the ileostomy status, the condition of DC may become increasingly severe. However, the corresponding pathogenesis of DC has not been clarified yet. Methods (1)Retrospective study: Clinical information were collected from patients with low rectal cancer admitted to the Department of Anorectal Surgery, Changzheng Hospital, from April 2017 to April 2019. These patients underwent laparoscopic low anterior resection (LAR) combined with terminal ileum enterostomy (dual-chamber). We used chi-square test to comparethe clinical baseline information, clinical symptoms, and endoscopic characteristics between different severity of DC; (2)Prospective nested case-control study: We recruited 40 patients with laparoscopic anterior low resection combined with terminal ileum enterostomy and they were further classified into mild group and severe group according to the scores of endoscopic examinations for DC. The following indexes were tested in the above two groups to verify histological differences between different severity of DC: Calprotectin in intestinal lavage fluid, inflammatory factors in tissue and plasma, and Lipopolysaccharide levels in plasma. Moreover, 16s-rDNA sequencing was carried out to analyze the diversity and and differences of microbiome in the intestinal lavage fluid of the two groups. Results (1)Retrospective study: According to the endoscopic scores, the retrospective clinical data were divided into 52 cases in the mild group and 58 cases in the severe group. We found that age, BMI, history of diabetes, and symptoms associated with the state of the stoma were the independent risk factors that affect DC severity ( P ༜0.05). Meanwhile, age, BMI, history of diabetes and endoscopic score were found to be independent risk factors affecting the severity of diarrhea after enterostomy( P༜ 0.05), which was consistent with our results of differentiating the severity of DC under endoscopy; (2)Prospective nested case-control study:40 patients with low rectal cancer recruited by sample size calculation, 23 were in the mild group and 17 in the severe group. In particular, Calprotectin in the intestinal lavage fluid, TNF-α, IL-1β, IL-6 and IL-17 in tissue/plasma, and Lipopolysaccharide in plasma of severe group were significantly higher than that of mild group ( P ༜0.05). The results of 16s-rDNA sequencing showed thatmicromicrobiome with high enrichment values primarily consisted of Bifidobacteriales and Prevotella in mild group, whereas that in the severe group consisted of Providencia and Dorea . The functional predictions on such two types of microbiome were mainly focused on lipid synthesis, glycan synthesis, metabolism, and amino acid metabolism pathways. Conclusion After enterostomy closure surgery, a series of severe clinical symptoms might appear in DC patients. There were significant differences in local and systemic inflammatory responses, composition of gut microbiota between DC patients with different endoscopic scores, which provide a basis for the clinical interventional treatment for enterostomy status-related DC in patients with permanent stoma.
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