A. Moreno

Tecnológico Nacional de México

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Enrique de Jesús Moreno Carpintero

Tecnológico Nacional de México

Alejandro Rojas Ayala

Tecnológico Nacional de México

Juan Antonio Martín Rubí

Instituto Geológico y Minero de España

Erik López García

Tecnológico Nacional de México

Manuel Pozo

Universidad Autónoma de Madrid

M.C. García-Donoso

Hospital Universitario de Fuenlabrada

I. Díaz de Corcuera

Hospital de Galdakao

A. Ruiz de Lobera

Hospital de Cruces

JÁ

Juan Á. Rivera

Centers for Disease Control and Prevention

Roque Piñole

Cooperative Institutions

Instituto de Salud Carlos III

Universitat de Barcelona

Tecnológico Nacional de México

Spanish National Cancer Research Centre

Centro de Investigación del Cáncer

Universitat Autònoma de Barcelona

Centro de Investigación Biomédica en Red

Vall d'Hebron Hospital Universitari

Hospital Clínic de Barcelona

Hospital Virgen de la Salud

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Mejoramiento de la Enseñanza de las Matemáticas Mediante Medios Electrónicos

Ciencia Latina Revista Científica Multidisciplinar (2023)

Erik López García Enrique de Jesús Moreno Carpintero Ma. Alicia Hernández-Flores A. Moreno Victoria Yazmin Atala Campos

Comparado con años anteriores, hoy en día tenemos un mayor índice de reprobación en la materia de matemáticas a nivel medio superior. Sin embargo, se pueden aprovechar sitios web de aprendizaje de matemáticas para mejorar la enseñanza, y este artículo es un ejemplo de ello. Aprovechando el sitio web de Khan Academy, los alumnos tuvieron esta herramienta para poder complementar su conocimiento de determinados temas vistos en clases; teniendo como resultado un mejor aprovechamiento en los alumnos que tuvieron acceso a esta herramienta, pero demostrándose también que las mujeres sacaron aún más un mejor beneficio.

10.37811/cl_rcm.v7i6.8848

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Synchronous activity in the nuclei Principalis, Oralis and Interpolaris of the rat under urethane anesthesia

Acta Neurobiologiae Experimentalis (2005)

Abel Sánchez‐Jiménez Víctor García‐González A. Moreno Fivos Panetsos

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Rationale for the use of immunomodulatory therapies in the Global Initiative for Asthma (GINA) step V asthma other than oral glucocorticosteroids

Internal Medicine Journal (2011)

Christian Domingo A. Moreno Rosa M. Mirapeix

Asthma is a major problem worldwide, which is estimated to affect 300 million individuals. The global prevalence ranges from 1% to 18% of the population. The incidence, morbidity and mortality of the condition have increased over the last 50 years despite the development of new anti-asthmatic drugs. Fewer than 1% of the asthmatic population are steroid-dependent, but these patients consume most of the resources and time at asthma units. The consensus documents published by professional societies all support a stepwise therapeutic approach for asthma. However, patients who require frequent or continuous oral corticosteroid administration have received little attention. Due to the severe side-effects of oral corticosteroids when administered over long periods or at high doses, many drugs have been assessed in the search for a possible corticosteroid-sparing agent. Recently, the update of the Global Initiative for Asthma (GINA) introduced a new drug--omalizumab--as an alternative to oral corticosteroids in patients included in step V. Other alternatives include immunosuppressive drugs, among which methotrexate has been found to offer the best benefit/risk ratio. This paper will review, comment and criticize the evidence of the effectiveness of immunomodulatory drugs, as an alternative to oral glucocorticosteroid treatment in GINA step V asthma patients. The experience of the authors combined with the information of the literature will lead to the conclusion that methotrexate and omalizumab are the only advisable drugs and will clarify when and how these drugs should be used.

Omalizumab

10.1111/j.1445-5994.2011.02481.x

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Aluminium Content in the Intravenous Treatment of Infants

WORLD SCIENTIFIC eBooks (1998)

A. Moreno C. Domínguez A Ballabriga

Content (measure theory)

10.1142/9789812817174_0012

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El modelado orientado a objeto como ayuda en el aprendizaje del comportamiento de dispositivos electrónicos

J.M. Flores A. Moreno Francisco Vázquez Serrano

El modelado orientado a objeto se presenta como una alternativa mas a los sistemas de modelado y simulacion de circuitos electronicos y,ademas, como una via de introduccion de una novedosa metodologia didactica ensenanza basada en el descubrimien

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Induction of the cancer-testis antigen MAGE-A3 in myeloma cell lines by 5’azacitidine and MGCD0103

Journal of Clinical Oncology (2008)

A. Moreno Susann Szmania Jun Shi Bart Barlogie G Prentice

14008 Background: MAGE-A3 is an immunogenic cancer testis antigen that is frequently expressed in high-risk multiple myeloma. We tested whether the demethylating agent 5’azacitidine (5’aza) and the histone deacetylase inhibitor MGCD0103 could modulate MAGE-A3 expression in MM cell lines. Methods: Myeloma cell lines ANBL-6, LP-1, RPMI 8226, OCI-MY5, OCI-MY1 and ARK were treated with 5’aza for 72 hrs followed by 24 hrs of normal media or MGCD0103. Fold change in MAGE-A3 RNA expression levels was assessed by real-time PCR using the ddCT method normalized to the internal control GAPDH. Cell viability was assessed by flow cytometry and methylation status of the MAGE-A3 promoter was determined by methylation specific PCR (MS-PCR). Results: MM cell lines positive for MAGE-A3 prior to treatment (RPMI 8226, OCI-MY5, OCI-MY1, and ARK) did not have appreciably increased MAGE-A3 expression after treatment, whereas MAGE-A3 expression was induced in previously negative lines ANBL-6 and LP1. Treatment with 500nM 5’aza increased MAGE-A3 transcripts an average of 73 fold (ANBL-6) and 24 fold (LP-1). A higher concentration of 1μM 5’aza led to greater MAGE-A3 expression but was also highly cytotoxic. MGCD0103 alone did not appreciably increase MAGE-A3 expression, however the addition of MGCD0103 for 24hrs after 5’aza led to a further 3.1 fold on average (ANBL6) and 2.2 fold on average (LP-1) increase in MAGE-A3 expression over 5’aza alone. MS-PCRindicated that the MAGE-A3 promoters in both ANBL-6 and LP-1 were hypermethylated prior to treatment and hypomethylated after treatment. The MM cell lines that were MAGE-A3 positive at baseline had hypomethylated promoters prior to treatment. Conclusions: The cancer testis antigen MAGE-A3 can be induced in MAGE-A3 negative myeloma by 5’aza and further increased by MGCD0103. Demethylating agents and histone deacetylase inhibitors may play a role in enhancing the efficacy of immunotherapy strategies targeting MAGE-A3. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Pharmion Pharmion Pharmion

Azacitidine

Demethylating agent

10.1200/jco.2008.26.15_suppl.14008

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Resultados contemporáneos de la reconstrucción de la unión mitroaórtica en endocarditis infecciosa aguda con afectación multivalvular: operación commando

Cirugía Cardiovascular (2019)

Alejandro Fernández‐Cisneros Elena Sandoval Manuel Castellà D Cordero Pereda Marta Hernández‐Meneses

10.1016/j.circv.2019.01.067

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Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A

Nature Communications (2022)

Silvana Mourón María José Sánchez Bueno Aña Lluch Luís Manso Isabel Calvo

Abstract Precision oncology research is challenging outside the contexts of oncogenic addiction and/or targeted therapies. We previously showed that phosphoproteomics is a powerful approach to reveal patient subsets of interest characterized by the activity of a few kinases where the underlying genomics is complex. Here, we conduct a phosphoproteomic screening of samples from HER2-negative female breast cancer receiving neoadjuvant paclitaxel ( N = 130), aiming to find candidate biomarkers of paclitaxel sensitivity. Filtering 11 candidate biomarkers through 2 independent patient sets ( N = 218) allowed the identification of a subgroup of patients characterized by high levels of CDK4 and filamin-A who had a 90% chance of achieving a pCR in response to paclitaxel. Mechanistically, CDK4 regulates filamin-A transcription, which in turn forms a complex with tubulin and CLIP-170, which elicits increased binding of paclitaxel to microtubules, microtubule acetylation and stabilization, and mitotic catastrophe. Thus, phosphoproteomics allows the identification of explainable factors for predicting response to paclitaxel.

Phosphoproteomics

Targeted Therapy

10.1038/s41467-022-35065-z

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Puesto de instrumentación virtual digital

J.I. Benavides J.C. García R. Llamuza A. Moreno Ortiz

En este trabajo se describe un Puesto de Instrumentacion Virtual (PIV) con fines docentes. Consta de un entorno de trabajo sobre un Computador Personal Compatible, que implementa un Analizador Logico y un Generador de Estimulos, que pueden funcionar independiente o conjuntamente, y un Frecuencimetro. Se ha desarrollado en el entorno Windows utilizando Visual C++, y basandose en Sistemas de Adquisicion de Datos de bajo coste desarrollados por el Grupo de Investigacion Arquitecturas Avanzadas de laUniversidad de Cordoba.

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Mineralogénesis de zeolitas en facies lacustres-palustres con arcillas magnésicas de la cuenca de Madrid

Boletín de la Sociedad Española de Mineralogía (1995)

Manuel Pozo José Casas Sáinz de Aja José Antonio Medina Núñez A. Moreno Juan Antonio Martín Rubí

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