Robert E. Casali

University of Florence

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Novelli Gp

University of Florence

Raymond C. Read

University of Arkansas for Medical Sciences

Fred T. Caldwell

University of Arkansas for Medical Sciences

Bruce Thompson

University of Melbourne

John S. Najarian

University of Minnesota

William J. Flanigan

University of Arkansas for Medical Sciences

Carl M. Kjellstrand

Loyola University Chicago

Kent C. Westbrook

University of Arkansas for Medical Sciences

Richard L. Simmons

University of Pittsburgh

G. P. Novelli

Policlinico Tor Vergata

Cooperative Institutions

University of Minnesota

University of Arkansas for Medical Sciences

Arkansas Department of Agriculture

University of Florence

Twin Cities Orthopedics

University of Arkansas Medical Center

University of Minnesota Medical Center

Azienda Ospedaliero-Universitaria Careggi

John L. McClellan Memorial Veterans Hospital

The University of Texas Southwestern Medical Center

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[Evaluation of the synergism between ketorolac and morphine in the treatment of postoperative pain].

PubMed (1995)

Robert E. Casali G Girardi Mediati Rd P Livi Novelli Gp

The aim of the study is to determine what concentration of ketorolac and morphine administered together i.v. achieve best synergic effect between NSAID antiinflammatory and opioids analgesic properties.Randomized comparative study was carried out on 180 patients, ASA II-IV, undergoing major general surgery, in an University Clinic.Postoperative pain therapy by i.v. PCA: group 1 morphine 0.75 mg.ml + ketorolac 0.75 mg.ml; group 2 morphine 0.50 mg.ml + ketorolac 1.50 mg.ml; group 3 morphine 0.25 mg.ml + ketorolac 1.50 mg.ml; in saline solution. Initial bolus: 2 ml. Continuous infusion 1.5 ml.h. Demand bolus: 0.2 ml. Lockout time: 30 minutes. Evaluations included: pain intensity (T0, T3, T18); total amount of infused drugs (T18); number of valid demands and attempts (T18); amount of autoadministered analgesic drugs in percent of highest available amount (T18); side effects (T18); patient's judgment.ANOVA and Student's "t"-test.A statistically significant reduction of pain intensity was found after 3 and 18 hours in the three groups, no differences were found among the groups. Group 2 required an amount of autoadministered drugs significantly lower than other groups. Rare side effects. Patient's judgment was generally positive.Results suggest a greater synergetic effect between morphine and ketorolac in concentrations used in group 2.

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Citations (2)

Etiology and prognosis in acute post-transplant renal failure

The American Journal of Medicine (1976)

Carl M. Kjellstrand Robert E. Casali Richard L. Simmons J. R. Shideman Theodore J. Buselmeier

Acute tubular necrosis

Etiology

10.1016/0002-9343(76)90169-8

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Citations (56)

[Nitrous oxide. Neurological, circulatory and cellular effects].

PubMed (1981)

Novelli Gp Robert E. Casali De Gaudio Ar Del Mese A S Falchi

Nitrous oxide

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Total infrarenal aortic occlusion

The American Journal of Surgery (1977)

Robert E. Casali E. A. T. Tucker Raymond C. Read Bruce Thompson

10.1016/0002-9610(77)90331-2

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Citations (27)

[Comparative study of the effects of morphine and tramadol in the treatment of postoperative pain].

PubMed (2000)

Robert E. Casali Antonella Lepri Q Cantini S. Landi G. P. Novelli

To compare morphine and tramadol in the treatment of postoperative pain (POP), using a system of Patient Controlled Analgesia (PCA).Randomised comparative study on 88 patients, undergoing general major surgical operations (gastrectomy, colectomy and hemicolectomy).PCA i.v.: group M treated with morphine (at a dilution of 1 mg/ml) and group T with tramadol (at a dilution of 10 mg/ml). Loading dose: 0.05 mg/kg for the group treated with morphine and 0.5 mg/kg for the group treated with tramadol. Baseline infusion: 1.5 ml/h. Bolus on demand: 0.2 ml every 30 minutes. At T0, after 1 hour, 3 and 18 hours assessment of pain intensity, level of sedation, respiratory and cardiocirculatory parameters. After 18 hours assessment of the amount of drug administered, the number of boluses requested and given and any side effects.ANOVA test, Student "t", chi 2.A statistically significant reduction in POP was found after 1 hour, 3 and 18 hours with no significant differences between the two groups. No statistically significant differences in cardiocirculatory or respiratory parameters or level of sedation were found. Few side effects were observed.Tramadol determines pain relief similar to morphine, with the advantage that it does not lead to abuse, tolerance or addiction.

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The local administration of relaxin induces changes in the microcirculation of the rat mesocaecum

European Journal of Endocrinology (1986)

Mario Bigazzi A. Del Mese Francesco Petrucci Robert E. Casali G. P. Novelli

Abstract. The clinical improvement of Reynaud's disease during pregnancy has been attributed to the increased relaxin (RLX) level in blood. Therefore we investigated the effect of topical porcine RLX (NIH-RXN-Pl) on the microcirculation of the mesocaecum of Wistar male rats, under direct microscope observation as judged by two observers. The hormone was applied locally to avoid systemic interferences either alone or after norepinephrine (NE) and promethazine (PM). The drugs were coded and the results were recorded independently by two observers. Porcine RLX induced rapid dilatation of the veins of the rat mesocaecum in a dose-related manner. The arteriolas and capillary flows were unchanged, while the venular flow was progressively reduced. The observed effects were sustained and disappeared with tissue wash-out. The RLX effects were reversed by addition of NE; conversely high doses of RLX were able to oppose the NE and PM vasospasm. We conclude that the local administration of RLX influences the microcirculation, possibly through an action on the smooth muscle of the venulae. The effects seems antagonistic with those of NE and PM.

Relaxin

Promethazine

10.1530/acta.0.1120296

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Citations (49)

Annals of Surgery (1976)

Robert E. Casali Richard L. Simmons Ronald M. Ferguson S. Michael Mauer Carl M. Kjellstrand

From January 1, 1968 to December 31, 1973, 50 patients received two or more kidney transplants. Patient and graft survival was highly dependent upon the source of the donor and to a lesser extent the functional duration of the first transplant and the elapsed time between first and second graft. Survival (patient and graft) was best in patients receiving two related grafts and worst in patients receiving two sequential cadaver grafts. Intermediate rates of success followed cadaver transplantation after rejection of a related graft. The highest failure rate was encountered when those patients who sustained an early loss of the first cadaver graft received a subsequent cadaver graft within a few months. We recommend removal of the acutely rejected graft and delay prior to retransplantation of patients who rapidly reject cadaver grafts in the face of maximal doses of immunosuppression. A delay will permit recovery from both the immunosuppression and any underlying subclinical infections, and will permit the recognition of anti-HL-A antibodies which may not be manifest soon after rejection. Retransplantation of the patient who is slowly rejecting the first kidney does not require prior removal of the rejected graft or delay in retransplantation.

10.1097/00000658-197608000-00002

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Citations (28)

The characterization of serum lipoproteins from portacaval shunted Macaca fasicularis monkeys

Biochemical Medicine (1979)

Charles A. Nelson Robert E. Casali Manford D. Morris

10.1016/0006-2944(79)90043-7

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Citations (7)

[Clinical evaluation of analgesia with lefetamine in thoracic surgery].

PubMed (1987)

Robert E. Casali Nesi Mg E Gentili Prisco Piscitelli