John F. Marshall

ExxonMobil (United States)

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Ian R. Hart

Cancer Institute (WIA)

Sarah Dickinson

University of South Florida

Gareth J. Thomas

University of Southampton

Dylan R. Edwards

University of East Anglia

Sarah J. Payne

University of Oklahoma Health Sciences Center

Marwa M. Dawoud

Menoufia University

IŠ

Ivana Šestak

Queen Mary University of London

Jennifer J. Gomm

Queen Mary University of London

Jack Cuzick

Queen Mary University of London

Sarah J. Clark

University of Michigan–Ann Arbor

Cooperative Institutions

Queen Mary University of London

Cancer Research UK

Southampton General Hospital

University of East Anglia

Mineral Resources

Guy's Hospital

University College London

Barts Health NHS Trust

Cancer Institute (WIA)

ExxonMobil (United States)

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Supplementary Figure 2 from αvβ6 Integrin Promotes the Invasion of Morphoeic Basal Cell Carcinoma through Stromal Modulation

D. R. Marsh Sarah Dickinson Graham W. Neill John F. Marshall Ian R. Hart

Supplementary Figure 2 from αvβ6 Integrin Promotes the Invasion of Morphoeic Basal Cell Carcinoma through Stromal Modulation

Modulation (music)

Basal (medicine)

10.1158/0008-5472.22375227

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Supplementary Figure Legends from Cyclooxygenase-2 Inhibition Suppresses αvβ6 Integrin–Dependent Oral Squamous Carcinoma Invasion

Maria Nyström Diana McCulloch Paul H. Weinreb Shelia M. Violette Paul M. Speight

Supplementary Figure Legends from Cyclooxygenase-2 Inhibition Suppresses αvβ6 Integrin–Dependent Oral Squamous Carcinoma Invasion

10.1158/0008-5472.22365693.v1

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Data from Altered Microenvironment Promotes Progression of Preinvasive Breast Cancer: Myoepithelial Expression of αvβ6 Integrin in DCIS Identifies High-risk Patients and Predicts Recurrence

Michael D. Allen Gareth J. Thomas Sarah J. Clark Marwa M. Dawoud Sabarinath Vallath

<div>AbstractPurpose: This study investigated the functional and clinical significance of integrin αvβ6 upregulation in myoepithelial cells of ductal carcinoma in situ (DCIS).Experimental Design: Archival samples of DCIS and DCIS with associated invasion (n = 532) were analyzed for expression of αvβ6 by immunohistochemistry and ability to predict recurrence and progression assessed in an independent, unique cohort of DCIS cases with long-term follow-up. Primary myoepithelial cells and myoepithelial cell lines, with and without αvβ6 expression, were used to measure the effect of αvβ6 on growth and invasion of tumor cell lines in vitro and in a xenograft mouse model. Involvement of TGFβ signaling was established using mink lung epithelial cell (MLEC) assay and antibody inhibition, and expression and activation of matrix metalloproteinase (MMP)-9 established by Real Time-PCR and zymography.Results: Expression of αvβ6 is significantly associated with progression to invasive cancer (P < 0.006) and with recurrence over a median follow-up of 114 months in a series of matched DCIS cases treated with local excision. We show that expression of αvβ6 drives myoepithelial cells to promote tumor cell invasion in vitro and enhances mammary tumor growth in vivo. The tumor-promoting effect of αvβ6-positive myoepithelial cells is dependent on TGFβ-driven upregulation of MMP9 and can be abrogated by inhibiting this pathway.Conclusion: These findings indicate that altered myoepithelial cells in DCIS predict disease progression and recurrence and show that upregulation of αvβ6 on myoepithelial cells generates a tumor promoter function through TGFβ upregulation of MMP-9. These data suggest that expression of αvβ6 may be used to stratify patients with DCIS. Clin Cancer Res; 20(2); 344–57. ©2013 AACR.</div>

Tumor progression

10.1158/1078-0432.c.6521699.v1

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Immunochemistry of CEACAM7 expression on PDAC from CEACAM7 Is an Effective Target for CAR T-cell Therapy of Pancreatic Ductal Adenocarcinoma

Deepak B. Thimiri Govinda Raj Maria Nikolaidi Irene Garces Daniela Lorizio Natalia M. Castro

Immunochemistry of CEACAM7 expression on PDAC

Immunochemistry

Pancreatic carcinoma

10.1158/1078-0432.22478882

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Supplementary Figure Legends 1-2 from αvβ6 Integrin Promotes the Invasion of Morphoeic Basal Cell Carcinoma through Stromal Modulation

D. R. Marsh Sarah Dickinson Graham W. Neill John F. Marshall Ian R. Hart

Supplementary Figure Legends 1-2 from αvβ6 Integrin Promotes the Invasion of Morphoeic Basal Cell Carcinoma through Stromal Modulation

Basal (medicine)

Modulation (music)

10.1158/0008-5472.22375224

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Supplementary Table 1 from Altered Microenvironment Promotes Progression of Preinvasive Breast Cancer: Myoepithelial Expression of αvβ6 Integrin in DCIS Identifies High-risk Patients and Predicts Recurrence

Michael D. Allen Gareth J. Thomas Sarah J. Clark Marwa M. Dawoud Sabarinath Vallath

PDF file - 55K, Supplementary Table 1. Details relating to; treatment received, patient age, hormone replacement therapy, mean follow up and pathological characteristics for cases and controls.

Table (database)

10.1158/1078-0432.22449587

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Refinery energy profile made

Hydrocarbon Process (1982)

J. R. White John F. Marshall Gary Shoemaker R.B. Smith

The energy used to refine crude oil into a spectrum of products is a small fraction of the energy contained in the products and varies considerably from refinery to refinery depending on refinery configuration, crude oil composition, and amounts of gasoline and distillate produced. The manufacture of some products such as lube oils and petrochemicals increases energy usage. The refinery energy change associated with small changes in gasoline volumes cannot be assigned in an absolute way. However, an approximation is possible by exploring how the energy is allocated over the refinery product slate. This paper gives some details about this approximation. 18 refs.

Refinery

Petrochemical

Petroleum product

Fraction (chemistry)

Refining (metallurgy)

Fuel oil

Energy source

Source

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A "transformation" method for calculating the research and motor octane numbers of gasoline blends

Industrial & Engineering Chemistry Fundamentals (1981)

Michael H. Rusin Harold S. Chung John F. Marshall

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA "transformation" method for calculating the research and motor octane numbers of gasoline blendsMichael H. Rusin, Harold S. Chung, and John F. MarshallCite this: Ind. Eng. Chem. Fundamen. 1981, 20, 3, 195–204Publication Date (Print):August 1, 1981Publication History Published online1 May 2002Published inissue 1 August 1981https://pubs.acs.org/doi/10.1021/i100003a003https://doi.org/10.1021/i100003a003research-articleACS PublicationsRequest reuse permissionsArticle Views526Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts

Octane rating

Motor oil

10.1021/i100003a003

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Citations (30)

Supplementary Figure 2 from Altered Microenvironment Promotes Progression of Preinvasive Breast Cancer: Myoepithelial Expression of αvβ6 Integrin in DCIS Identifies High-risk Patients and Predicts Recurrence

Michael D. Allen Gareth J. Thomas Sarah J. Clark Marwa M. Dawoud Sabarinath Vallath

PDF file - 108K, Supplementary Figure 2. alphavbeta6 functional assays in the beta6-1089 cell line using RNAi.

Expression (computer science)

10.1158/1078-0432.22449596

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