Olga Ciepiela

Medical University of Warsaw

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Co-Authors

Urszula Demkow

Medical University of Warsaw

Iwona Kotuła

Medical University of Warsaw

Milena Małecka‐Giełdowska

Medical University of Warsaw

Aneta Manda‐Handzlik

Medical University of Warsaw

Anna Zawadzka‐Krajewska

Medical University of Warsaw

Weronika Bystrzycka

Medical University of Warsaw

Anna Adamowicz‐Salach

Medical University of Warsaw

Sandra Sieczkowska

Medical University of Warsaw

Dominika Nowis

Medical University of Warsaw

Jakub Gołąb

Medical University of Warsaw

Cooperative Institutions

Medical University of Warsaw

206

Polish Academy of Sciences

University of Warsaw

University Clinical Centre

Medical University of Lublin

Children's Memorial Health Institute

Postgraduate School of Molecular Medicine

Jagiellonian University

Medical University of Silesia

Poznan University of Medical Sciences

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Usefulness of Reticulocyte Parameters for Diagnosis of Hereditary Spherocytosis in Children

Indian Journal of Hematology and Blood Transfusion (2016)

Olga Ciepiela Anna Adamowicz‐Salach Andżelika Radgowska Katarzyna Żbikowska Iwona Kotuła

Reticulocyte

Hereditary spherocytosis

Hematology

10.1007/s12288-016-0680-0

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Citations (8)

Hypersegmentation of granulocytes and monocytes in patient with primary myelofibrosis treated with hydroxycarbamide

Turkish Journal of Hematology (2019)

Monika Blocka - Gumowska Justyna Holka Olga Ciepiela

Hydroxycarbamide

10.4274/tjh.2018.0395

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Citations (0)

Clinical immunology Recurrent respiratory tract infections in children – analysis of immunological examinations

Central European Journal of Immunology (2015)

Agata Raniszewska Elżbieta Górska Iwona Kotuła Anna Stelmaszczyk‐Emmel Katarzyna Popko

Paediatric respiratory tract infections are among the most common reasons for preschool and school absences and visits to physicians. The disease mainly involves the upper respiratory tract and is associated with fever, cough, sore throat, and running nose. Children with recurrent respiratory infections (RRI), which are defined as more than six serious diseases a year, are a difficult diagnostic challenge. The aim of this study was to assess immunological deviations in laboratory tests performed in children with RRI.

Respiratory tract

Clinical immunology

10.5114/ceji.2015.52830

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Citations (30)

Laboratory work safety rules and guidelines during COVID-19 pandemic in Polish clinical laboratories – do our laboratories work according to a recent IFCC Taskforce Recommendations?

Clinical Chemistry and Laboratory Medicine (CCLM) (2020)

Milena Małecka Kinga Ogrodzińska Gabriela Salczyńska Olga Ciepiela

Article Laboratory work safety rules and guidelines during COVID-19 pandemic in Polish clinical laboratories – do our laboratories work according to a recent IFCC Taskforce Recommendations? was published on October 1, 2020 in the journal Clinical Chemistry and Laboratory Medicine (CCLM) (volume 58, issue 10).

Pandemic

Laboratory Safety

Medical laboratory

2019-20 coronavirus outbreak

10.1515/cclm-2020-0764

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Citations (6)

The Role of Light Kappa and Lambda Chains in Heart Function Assessment in Patients with AL Amyloidosis

Journal of Clinical Medicine (2021)

Emilia Czyżewska Agnieszka Wiśniewska Anna Waszczuk‐Gajda Olga Ciepiela

There are reports indicating that myocardial dysfunction in systemic immunoglobulin light chain amyloidosis (AL amyloidosis) stems not only from the amyloid deposit in the organ but also the cardiotoxicity of the amyloid precursor free light chains (FLCs) circulating in the blood. The aim of the study is to analyze the role of sFLC κ and λ in the assessment of heart involvement and the degree of myocardial damage in AL amyloidosis. The study involved 71 patients diagnosed with primary AL amyloidosis. The relationship between sFLC concentrations and cardiac biochemical and echocardiographic parameters was assessed. The median concentrations of N-terminal pro b-type natriuretic peptide(NT-proBNP) and troponin I (TnI) were significantly higher in patients with amyloids formed from monoclonal λ chains compared to patients with monoclonal κ proliferation. In patients with heart involvement by amyloids formed from monoclonal FLC, the study demonstrated a statistically significant positive correlation between the concentration of monoclonal antibody λ chain and TnI (R = 0.688; p < 0.05), NT-proBNP (R = 0.449; p < 0.05), and the value of diastolic dimension of the interventricular septum (IVS; R = 0.496, p < 0.05). The above data indicate that the presence of monoclonal λ chains in patients with AL amyloidosis may be associated with more severe damage to cardiomyocytes and dysfunction of the myocardium.

AL amyloidosis

Cardiac Amyloidosis

Amyloid (mycology)

10.3390/jcm10061274

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Citations (8)

A comparison of D-dimer concentration determination using different methods in automated hemostatis analyzers ACL TOP 500 CTS, ACL TOP 700 CTS, and VIDAS

Diagnostyka Laboratoryjna (2022)

Milena Małecka‐Giełdowska Karolina Nowak Aleksandra Leszczyńska Olga Ciepiela

Introduction: D-dimer is a product of stabilized fibrin degradation under the influence of plasmin. Evaluation of D-dimer concentration is crucial in exclusion of thromboembolism as well as in monitoring of coagulation and fibrinolysis processes in affected patients. Concentration of D-dimer corresponds with dynamics of clot formation and degradation in vessels. Aim: The aim of the study was to evaluate interchangeability of different analysers: ACL TOP 500 CTS, ACL TOP 700 CTS and VIDAS 3 in D-dimer assessment. Material and methods: Study included D-dimer measurements in 4476 patients. There were statistically significant differences in D-dimer concentration obtained with reference ELFA method and immunoturbidymetric method, both in women and men groups. Results: There were also significant differences in D-dimers concentration when studying samples with D-dimer of 500-1500 mg/L obtained with ACL TOP, with lower values obtained with VIDAS 3. Conclusions: Basing on our results it can be stated, that ELFA and immunoturbidymetric method are not interchangeable and should not be used in assessment of D-dimer concentration in one patient interchangeably.

D-dimer

10.5604/01.3001.0016.1351

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Antibiotics Modulate the Ability of Neutrophils to Release Neutrophil Extracellular Traps

Advances in experimental medicine and biology (2016)

Aneta Manda‐Handzlik Weronika Bystrzycka Sandra Sieczkowska Urszula Demkow Olga Ciepiela

Neutrophil Extracellular Traps

10.1007/5584_2016_59

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Citations (24)

Influence of Different Bacteria Strains Isolated from Septic Children on Release and Degradation of Extracellular Traps by Neutrophils from Healthy Adults

Advances in experimental medicine and biology (2018)

Weronika Bystrzycka Sandra Sieczkowska Aneta Manda‐Handzlik Joanna Rogulska Aneta Moskalik

Neutrophil Extracellular Traps

Stenotrophomonas maltophilia

10.1007/5584_2018_245

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Citations (1)

Dynamic Changes in the Ability to Release Neutrophil ExtraCellular Traps in the Course of Childhood Acute Leukemias

International Journal of Molecular Sciences (2021)

Magdalena Ostafin Olga Ciepiela Michał P. Pruchniak Małgorzata Wachowska Edyta Ulińska

Acute leukemias, the most common cancers in children, are characterized by excessive proliferation of malignant progenitor cells. As a consequence of impaired blood cell production, leukemia patients are susceptible to infectious complications—a major cause of non-relapse mortality. Neutrophil extracellular traps (NETs) are involved in various pathologies, from autoimmunity to cancer. Although aberrant NETs formation may be partially responsible for immune defects observed in acute leukemia, still little is known on the NET release in the course of leukemia. Here, we present the first comprehensive evaluation of NETs formation by neutrophils isolated from children with acute leukemia in different stages of the disease and treatment stimulated in vitro with phorbol 12-myristate 13-acetate (PMA), N-formyl-methionyl-leucyl-phenylalanine (fMLP), and calcium ionophore (CI). NETs release was measured using quantitative fluorescent method and visualized microscopically. In this setting, NETs release was significantly impaired in leukemic children both at the diagnosis and during the treatment, and full restoration of neutrophil function was achieved only after successful completion of the leukemia treatment. We suggest that neutrophil function impairment may result from both disease- and treatment-related factors. In this context, deficient innate immune response observed in acute leukemia patients may be present regardless of neutrophil count and contribute to secondary immunodeficiency observed in this population.

Neutrophil Extracellular Traps

10.3390/ijms22020821

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Citations (14)

Extremely severe anemia—Worsening a patient’s condition in the COVID‐19 pandemic era

International Journal of Laboratory Hematology (2021)

Milena Małecka Monika Błocka‐Gumowska Olga Ciepiela

None.

Microcytic anemia

Soluble transferrin receptor

Creatine kinase

10.1111/ijlh.13493

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Citations (0)