Hua‐Fu Zhou

First Affiliated Hospital of GuangXi Medical University

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Gang Chen

First Affiliated Hospital of GuangXi Medical University

Guosheng Li

Qilu Hospital of Shandong University

Jinliang Kong

First Affiliated Hospital of GuangXi Medical University

Rong‐Quan He

First Affiliated Hospital of GuangXi Medical University

Shangwei Chen

The People's Hospital of Guangxi Zhuang Autonomous Region

Yi‐Wu Dang

First Affiliated Hospital of GuangXi Medical University

Feng Xu

Ningbo Medical Center Lihuili Hospital

Wenzhou Liu

Sun Yat-sen Memorial Hospital

Zhi‐Guang Huang

First Affiliated Hospital of GuangXi Medical University

Zong-Wang Fu

First Affiliated Hospital of GuangXi Medical University

Cooperative Institutions

Guangxi Medical University

174

First Affiliated Hospital of GuangXi Medical University

159

Sun Yat-sen University

Shanghai Jiao Tong University

Chinese Academy of Medical Sciences & Peking Union Medical College

Sichuan University

Huazhong University of Science and Technology

Central South University

Jilin University

Fudan University

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EP02.03-06 Suppression of the Long Non-coding RNA LINC01279 Triggers Autophagy in Lung Cancer by Regulating SIN3A

Journal of Thoracic Oncology (2023)

Wenmei Su J. Wu Xudong Huang Xiaoling Li Hua‐Fu Zhou

10.1016/j.jtho.2023.09.791

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Prognostic alternative splicing signatures and underlying regulatory network in esophageal carcinoma.

PubMed (2019)

Zucheng Xie Huayu Wu Fu‐Chao Ma Yi‐Wu Dang Zhigang Peng

Alternative splicing (AS) has been widely reported to play an important role in cancers, including esophageal carcinoma (ESCA). However, no study has comprehensively investigated the clinical use of combination of prognostic AS events and clinicopathological parameters. Therefore, we collected 165 ESCA patients including 83 esophageal adenocarcinoma (EAC) and 82 esophageal squamous cell carcinoma (ESCC) patients from The Cancer Genome Atlas to explore the survival rate associated with seven types of AS events. Prognostic predictors for the clinical outcomes of ESCA patients were built. Predictive prognosis models of the alternative acceptor site in ESCA (area under the curve [AUC] = 0.83), alternative donor site in EAC (AUC = 0.99), and alternative terminator site in ESCC (AUC = 0.974) showed the best predictive efficacy. A novel combined prognostic model of AS events and clinicopathological parameters in ESCA was also constructed. Combined prognostic models of ESCA all showed better predictive efficacy than independent AS models or clinicopathological parameters model. Through constructing splicing regulatory network, the expression of AS factor was found to be negatively correlated with the most favorable AS events. Moreover, gene amplification, mutation, and copy number variation of AS genes were commonly observed, which may indicate the molecular mechanism of how the AS events influence survival. Conclusively, the constructed prognostic models based on AS events, especially the combined prognostic models of AS signatures and clinicopathological parameters could be used to predict the outcome of ESCA patients. Moreover, the splicing regulatory network and genomic alteration in ESCA could be used for illuminating the potential molecular mechanism.

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The more potential performance of nidogen 2 methylation by tissue or plasma DNA over brichoalveolar lavage DNA in diagnosis of nonsmall cell lung cancer

Journal of Cancer Research and Therapeutics (2018)

Feng Xu Xiaoyong Xie Baoshi Zheng Chaoyang Peng Hua‐Fu Zhou

Nonsmall cell lung cancer (NSCLC) is one of the leading incidence and mortality of malignant tumors worldwide. While aberrant DNA methylation is a frequent event occurred during NSCLC carcinogenesis and development, therefore holding the potential to predict the process of tumor development. This study aims to explore the feasibility of gene nidogen 2 (NID2) as the diagnostic biomarker for NSCLC.Quantitative methylation specific polymerase chain reaction of NID2 has been done among the following sample panels: For tissue methylation evaluation, we collected 96 cases of NSCLC versus 18 cases of noncancerous lung lesions (NCLLs); 46 from the 96 NSCLC patients also provided DNA of bronchoalveolar lavage (BAL) and plasma sample, the methylation status of which are assessed against 12 cases of NCLL for BAL and 30 cases of NCLL for plasma samples, respectively.The methylation rate of NID2 in NSCLC versus NCLL is evaluated as: In tissue 59.40% versus 16.67%, (P = 0.0001); in BAL 30.43% versus 16.67% (P = 0.1640); in plasma 45.65% versus 20.00% (P = 0.0191).Our study revealed the frequent occurrence of aberrant NID2 methylation in NSCLC and peripheral blood, which might be useful as a biomarker to predict NSCLC or to screen the high-risk population for NSCLC.

10.4103/0973-1482.235352

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The clinical significance of integrin subunit alpha V in cancers: from small cell lung carcinoma to pan-cancer

BMC Pulmonary Medicine (2022)

Yu-Lu Tang Guosheng Li Dongming Li Deng Tang Jie-Zhuang Huang

Abstract Background Little is known about the relationship between integrin subunit alpha V ( ITGAV ) and cancers, including small cell lung cancer (SCLC). Methods Using large sample size from multiple sources, the clinical roles of ITGAV expression in SCLC were explored using differential expression analysis, receiver operating characteristic curves, Kaplan–Meier curves, etc. Results Decreased mRNA (SMD = − 1.05) and increased protein levels of ITGAV were detected in SCLC ( n = 865). Transcription factors—ZEB2, IK2F1, and EGR2—may regulate ITGAV expression in SCLC, as they had ChIP-Seq (chromatin immunoprecipitation followed by sequencing) peaks upstream of the transcription start site of ITGAV . ITGAV expression made it feasible to distinguish SCLC from non-SCLC (AUC = 0.88, sensitivity = 0.78, specificity = 0.84), and represented a risk role in the prognosis of SCLC ( p < 0.05). ITGAV may play a role in cancers by influencing several immunity-related signaling pathways and immune cells. Further, the extensive pan-cancer analysis verified the differential expression of ITGAV and its clinical significance in multiple cancers. Conclusion ITGAV served as a potential marker for prognosis and identification of cancers including SCLC.

10.1186/s12890-022-02095-8

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単関節器械による胸部の胸部腫瘍切除の早期経験【JST・京大機械翻訳】

Zhonghua Qiangjing Waike Zazhi (Dianziban) (2016)

Liu Tao Huang Yingtong Xiaoying Yan Guo Jianji Hua‐Fu Zhou

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MMP12 is a Potential Predictive and Prognostic Biomarker of Various Cancers Including Lung Adenocarcinoma

Cancer Control (2024)

Guosheng Li Yu-Xing Tang Wei Zhang Jian‐Di Li Heqing Huang

Objective This study sought to explore the clinical value of matrix metalloproteinases 12 ( MMP12) in multiple cancers, including lung adenocarcinoma (LUAD). Methods Using >10,000 samples, this retrospective study demonstrated the first pan-cancer analysis of MMP12. The expression of MMP12 between cancer groups and their control groups was analyzed using Wilcoxon rank-sum tests. The clinical significance of MMP12 expression in multiple cancers was assessed using receiver operating characteristic curves, Kaplan–Meier curves, and univariate Cox analysis. A further LUAD-related analysis based on 4565 multi-center and in-house samples was performed to verify the findings regarding MMP12 in pan-cancer analysis partly. Results MMP12 mRNA is highly expressed in 13 cancers compared to their controls, and the MMP12 protein level is elevated in some of these cancers (e.g., colon adenocarcinoma) ( P < .05). MMP12 expression makes it feasible to distinguish 21 cancer tissues from normal tissues (AUC = 0.86). A high MMP12 expression is a prognosis risk factor in eight cancers, such as adrenocortical carcinoma (hazard ratio >1, P < .05). The elevated MMP12 expression is also a prognosis protective factor in breast-invasive carcinoma and colon adenocarcinoma (hazard ratio <1, P < .05). Some pan-cancer findings regarding MMP12 are verified in LUAD—MMP12 expression is upregulated in LUAD at both the mRNA and protein levels ( P < .05), has the potential to distinguish LUAD with considerable accuracy (AUC = .91), and plays a risk prognosis factor for patients with the disease ( P < .05). Conclusions MMP12 is highly expressed in most cancers and may serve as a novel biomarker for the prediction and prognosis of numerous cancers.

10.1177/10732748241235468

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Overexpression of cyclin‐dependent kinase 1 in esophageal squamous cell carcinoma and its clinical significance

FEBS Open Bio (2021)

Han‐Jie Zhang Gang Chen Shangwei Chen Zong‐Wang Fu Hua‐Fu Zhou

Cyclin‐dependent kinase 1 (CDK1) plays a significant role in certain malignancies. However, it remains unclear whether CDK1 plays a role in esophageal squamous cell carcinoma (ESCC). The aim of this study was to analyze the expression and clinical value of CDK1 in ESCC. CDK1 protein in 151 ESCC tissues and 138 normal esophageal tissues was detected by immunohistochemistry. RNA‐seq of eight pairs of ESCC and adjacent esophageal specimens was performed to evaluate the levels of CDK1 mRNA. Microarray and external RNA‐seq data from 664 cases of ESCC and 1733 cases of control tissues were used to verify the difference in CDK1 expression between the two groups. A comprehensive analysis of all data was performed to evaluate the difference in CDK1 between ESCC tissues and control tissues. Further, functional enrichment analyses were performed based on differentially expressed genes (DEGs) of ESCC and co‐expressed genes (CEGs) of CDK1. In addition, a lncRNA‐miRNA‐ CDK1 network was constructed. The expression of CDK1 protein was obviously increased in ESCC tissues (3.540 ± 2.923 vs. 1.040 ± 1.632, P < 0.001). RNA‐seq indicated that the mRNA level of CDK1 was also highly expressed in ESCC tissues (5.261 ± 0.703 vs. 2.229 ± 1.161, P < 0.0001). Comprehensive analysis revealed consistent up‐regulation of CDK1 (SMD = 1.41; 95% CI 1.00–1.83). Further, functional enrichment analyses revealed that the functions of these genes were mainly concentrated in the cell cycle. A triple regulatory network of PVT1‐hsa‐miR‐145‐5p/hsa‐miR‐30c‐5p‐ CDK1 was constructed using in silico analysis. In summary, overexpression of CDK1 is closely related to ESCC tumorigenesis.

10.1002/2211-5463.13306

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Correlation between hemoglobin and the risk of common malignant tumors: a 1999–2020 retrospective analysis and causal association analysis

BMC Cancer (2024)

Guosheng Li Tao Huang Jing-Xiao Li Jun Liu Xiang Gao

The role of hemoglobin (HGB) in common malignant tumors remains unclear.

Surgical oncology

Association (psychology)

Causality

10.1186/s12885-024-12495-0

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A Novel 5-Methylcytosine- and Immune-Related Prognostic Signature Is a Potential Marker of Idiopathic Pulmonary Fibrosis

Computational and Mathematical Methods in Medicine (2022)

Tao Huang Hua‐Fu Zhou

Idiopathic pulmonary fibrosis (IPF) is the most common and highly lethal pulmonary interstitial lung disease. The current study is aimed at investigating reliable markers suitable for the treatment and identification of IPF. This study constructed the first 5-methylcytosine- (m5C-) and immune-related prognostic signature (m5CPS) based on coexpressed genes of m5C regulatory genes and immune-related genes. The m5CPS was established using the training cohort (n = 68) and verified using the test (n = 44) and validation (n = 64) cohorts. The area under the curve (AUC) values were utilized to evaluate the accuracy of m5CPS in predicting the survival of IPF patients. The Kaplan-Meier curves and Cox regression analyses were used to assess the prognostic effect of m5CPS. The AUC was utilized to evaluate the reliability of m5CPS in distinguishing IPF patients from healthy individuals. In terms of the results, m5CPS could predict the one-, three-, and five-year survival rates of IPF patients with high accuracy (AUC = .803-.973). In fact, m5CPS is not only an independent indicator of the poor prognosis of IPF patients (hazard ratio > 1; p < .05) but can also distinguish IPF patients from healthy individuals (AUC = .862). Also, m5CPS may affect the immune response and inflammatory response, and it was positively associated with the infiltration levels of active mast cells (p < .05). In sum, the current study establishes a novel m5CPS for IPF and reveals the role of m5CPS as a reliable marker for predicting the prognosis and disease status of IPF patients.

10.1155/2022/1685384

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Clinical experience of surgical treatment of pleural empyema in infants

Chinese Journal of New Clinical Medicine (2011)

Hua‐Fu Zhou

Objective To summarize the experience of surgical treatment of pleural empyema in infants. Methods The clinical data of 21 infants with pleural empyema undergone surgical operation in our hospital from January 2005 to August 2010 were retrospectively analyzed. Results All of the infants received surgical operation; 5 patients underwent pulmonary wedge resection, 3 patients underwent lobectomy. Smooth recovery were achieved in all patients; No perioperative death and complication occurred. Conclusion Surgical operation is an effective method for pleural empyema in infants.

Pleural empyema

Wedge resection

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