Solmaz Khalifeh

Islamic Azad University Medical Branch of Tehran

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Mohammad‐Reza Zarrindast

Tehran University of Medical Sciences

Mitra‐Sadat Sadat‐Shirazi

Tehran University of Medical Sciences

Hamed Ghazvini

Mazandaran University of Medical Sciences

Ghorbangol Ashabi

Tehran University of Medical Sciences

Afshin Kheradmand

Iran University of Medical Sciences

Fariba Khodagholi

Shahid Beheshti University of Medical Sciences

Ardeshir Akbarabadi

Tehran University of Medical Sciences

Mehdi Khodamoradi

Kermanshah University of Medical Sciences

Nasim Vousooghi

Tehran University of Medical Sciences

Setareh Nouri Zadeh‐Tehrani

University of British Columbia

Cooperative Institutions

Tehran University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Islamic Azad University Medical Branch of Tehran

University of Tehran

Islamic Azad University, Tehran

Institute for Cognitive Science Studies

Kerman University of Medical Sciences

Iran University of Medical Sciences

Shahid Beheshti University

Tabriz University of Medical Sciences

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Role of Chloroquine and Cocaine Injection on Synaptophysin Protein Level in PTSD Model of Male Wistar Rat

Somayeh Akhavan Hooman Shajiee Vida Hojati Shahram Sharafi Solmaz Khalifeh

Introduction: Drug abuse could induce molecular changes in synapses, leading to mood-related disorders. In addition, some patients suffering from mood disease use drug to get comfort. In some behavioral disorders, autophagy inhibitor drugs are used. Materials and Methods: In the current study, the effect of chloroquine (CQ, an autophagy inhibitor drug) in a rat model of Post-Traumatic Stress Disorder (PTSD), together with the role of cocaine abuse was examined. Rats were injected with the CQ and/or cocaine alone or following single-prolonged-stress exposure and were confirmed as PTSD, using elevated-plus maze (EPM) test and then protein level of synaptophysin (a synaptic vesicle glycoprotein ) was investigated by western blotting tecnique. It should be noted that cocaine was administered intracerebroventricularly (i.c.v, 20µg/rat) and CQ was administered intraperitoneally (50 mg/kg, IP). Results: Obtained data revealed that PTSD and chronic administration of cocaine (i.c.v) in PTSD animals could increase the level of Synaphtophysin. CQ injection in them decreased Synaptophysin. So cocaine increase Synaphtophysin while CQ decrease it in PTSD animals. Conclusion: The current data suggests altering neural plasticity by Synaptophysin protein level changes in brain on PTSD rats.

Synaptophysin

Cocaine abuse

10.22037/aab.v11i1.28165

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The role of cannabinoid 1 receptor in the nucleus accumbens on tramadol induced conditioning and reinstatement

Life Sciences (2020)

Mahsa Sadeghi-Adl Mitra‐Sadat Sadat‐Shirazi Faezeh Shahini Ardeshir Akbarabadi Solmaz Khalifeh

Conditioned place preference

AM251

Extinction (optical mineralogy)

10.1016/j.lfs.2020.118430

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Citations (7)

Morphine exposure before conception affects anxiety-like behavior and CRF level (in the CSF and plasma) in the adult male offspring

Brain Research Bulletin (2018)

Saba Sabzevari Kiyana Rohbani Mitra‐Sadat Sadat‐Shirazi Nima Babhadi‐Ashar Atena Shakeri

Elevated plus maze

10.1016/j.brainresbull.2018.11.022

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Citations (27)

The role of lateral habenula NMDA receptors in tramadol-induced conditioning

Behavioural Pharmacology (2023)

Arman Hajikarim‐Hamedani Amirhossein Heidari Mitra‐Sadat Sadat‐Shirazi Sarah Mahboubi Samira Raminfard

The role of the lateral habenula (LHb) as a hub for receiving and relaying signals from the limbic system to serotonergic, dopaminergic, and norepinephrinergic regions in the brainstem makes this area a critical region in the control of reward and addiction. Behavioral evidence reveals the vital role of the LHb in negative symptoms during withdrawal. In this investigation, we study the role of the LHb N-Methyl D-Aspartate receptor (NMDAR) in the modulation of tramadol reward. Male adult Wistar rats were used in this study. The effect of intra-LHb micro-injection of NMDAR agonist (NMDA, 0.1, 0.5, 2 µg/rat) and antagonist (D-AP5, 0.1, 0.5, 1 µg/rat) was evaluated in conditioned place preference (CPP) paradigm. The obtained results showed that intra-LHb administration of NMDA induced place aversion dose-dependently, while blockade of NMDAR in the LHb using D-AP5 micro-injection led to an increased preference score in the CPP task. Co-administration of NMDA (0.5 µg/rat) with tramadol (4 mg/kg) reduced preference score, while co-administration of D-AP5 (0.5 µg/rat) with a non-effective dose of tramadol (1 mg/kg) potentiate the rewarding effect of tramadol. LHb receives inputs from the limbic system and projects to the monoaminergic nuclei in the brainstem. It has been declared that NMDAR is expressed in LHb, and as obtained data revealed, these receptors could modulate the rewarding effect of tramadol. Therefore, NMDA receptors in the LHb might be a new target for modulating tramadol abuse.

Conditioned place preference

Memantine

Monoaminergic

10.1097/fbp.0000000000000730

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Does Morphine Exposure Before Gestation Change Anxiety-Like Behavior During Morphine Dependence in Male Wistar Rats?

Addiction and Health (2023)

Saba Sabzevari Kiyana Rohbani Mahsa Sadeghi-Adl Solmaz Khalifeh Mitra‐Sadat Sadat‐Shirazi

Anxiety is one of the comorbid disorders of opioid addiction, which leads to opioid abuse or persuades people to engage in opioid abuse. Evidence revealed that morphine exposure before conception changes the offspring's phenotype. The current study aimed to investigate the influence of morphine dependence and abstinence on anxiety-like behavior in morphine-exposed and drug-naïve offspring.Adult male and female rats were treated with morphine or vehicle for 21 days. Then, all rats were left without drug treatment for 10 days. A morphine-exposed female rat was mated with either a vehicle-exposed or morphine-abstinent male. According to parental morphine exposure, the offspring were categorized into four distinct groups: (1) control (both drug-naïve parents), (2) paternal morphine-exposed, (3) maternal morphine-exposed, and (4) biparental morphine-exposed. The anxiety-like behavior was measured in adult male offspring using open field and elevated plus-maze tests before morphine exposure (naïve), 21 days after morphine exposure (dependence), and ten days after the last morphine exposure (abstinence).The results indicated that anxiety-like behavior increased before morphine exposure in maternal and biparental morphine-exposed offspring (P<0.05). However, after morphine exposure, the anxiety level did not change among the groups. Ten days after the last morphine exposure, anxiety-like behavior increased only in biparental morphine-exposed offspring (P<0.05).The offspring of morphine-abstinent parents exhibited an anxious phenotype. Disruption of the HPA axis was seen in the progeny of maternal and biparental morphine-exposed rats. Indeed, morphine exposure for 21 days did not change anxiety-like behavior in these offspring which might be correlated to disruption of HPA axis in them.

Elevated plus maze

10.34172/ahj.2023.1396

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Citations (3)

Dose-dependent manner of luteolin in the modulation of spatial memory with respect to the hippocampal level of HSP70 and HSP90 in sleep-deprived rats

Gene (2022)

Parisa Rahimpour Mohammad Nasehi Mohammad‐Reza Zarrindast Solmaz Khalifeh

Memory Impairment

10.1016/j.gene.2022.147046

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Citations (7)

Beyond the 5-HT3 receptors

Human & Experimental Toxicology (2015)

Solmaz Khalifeh Gohar Fakhfouri SE Mehr Kazem Mousavizadeh‬Ahmad Reza Dehpour

Accumulation of reactive oxygen species, such as hydrogen peroxide (H 2 O 2 ), generated by inflammatory cells or other pathological conditions, leads to oxidative stress, which may contribute to the neuronal degeneration observed in a wide variety of neurodegenerative disorders such as Alzheimer’s disease. Recent investigations have described effective properties of tropisetron, such as antiphlogistic action or protection against β-amyloid induced-neuroinflammation in rats. Our data revealed that H 2 O 2 -induced cell death in rat pheochromocytoma cell line (PC12) can be inhibited by tropisetron, as defined by 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyl tetrazolium bromide assay, caspase 3 and caspase 12 levels. We further showed that tropisetron exerts its protective effects by upregulation of heme oxygenase-1, glutathione, catalase activity, and nuclear factor-erythroid 2 p45-related factor 2 level. Moreover, tropisetron was recently found to be a partial agonist of α7 nicotinic acetylcholine receptor (α7nAChR). The activation of α7nAChR could inhibit inflammatory and apoptotic signaling pathways in the oxidative stress conditions. In this study, selective α7nAChR antagonists (methyllycaconitine) reversed the effects of tropisetron on caspase 3 level. Our findings indicated that tropisetron can protect PC12 cells against H 2 O 2 -induced neurotoxicity through α7nAChR in vitro.

Methyllycaconitine

Tropisetron

Neurotoxicity

10.1177/0960327114562034

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Citations (17)

Effects of Maternal Deprivation on Anxiety, Depression, and Empathy in Male and Female Offspring of Wistar Rats in the Face of Novel Objects

Galen Medical Journal (2019)

Solmaz Khalifeh Fariba Khodagholi Mehrad Moghtadaei Ali Behvarmanesh Afshin Kheradmand

Early life stress (ELS) models such as maternal deprivation (MD) are used to investigate behavioral changes in rodents under stressful situations. MD is a situation in which rat pups are separated from the dam; MD has different paradigms. The purpose of this research is to evaluate the effects of maternal deprivation on anxiety, depression, and empathy in adult Wistar rats.MD was applied to pups as per specifically designed protocol to compare rats of the control group with maternal deprivation rats and also the group, which faced novel objects. Each group consisted of eight rats. In this study, separation started from postnatal day (PND) 14 for various periods up to PND 60. EPM test was undertaken to measure anxiety; moreover, FST was used to indicate levels of depression. Also, changes in the empathy ratio were also demonstrated. One-way analysis of variance (ANOVA), Tukey's post hoc analysis, and t-test were applied to analyze the results.MD-treated rats showed a significant decrease in anxiety and empathy indexes compared with those in the control group (P<0.05). However, MD significantly increased depression in both male and female rats (P<0.05). Finally, exposure to novel objects decreased depression but did not have any effect on anxiety and empathy levels in MD rats (P<0.05).ELS may lead to various states of mood and behavior in adulthood. According to the findings of this study, depression increases due to MD, though both anxiety and empathy decrease in both male and female Wistar rats. Moreover, exposure to novel objects decreases depression, while anxiety and empathy do not change significantly with exposure to novel objects.

Depression

Elevated plus maze

Maternal deprivation

10.31661/gmj.v0i0.1093

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Citations (6)

Complexity of Compensatory Effects in Nrf1 Knockdown: Linking Undeveloped Anxiety-Like Behavior to Prevented Mitochondrial Dysfunction and Oxidative Stress

Cellular and Molecular Neurobiology (2015)

Solmaz Khalifeh Shahrbanoo Oryan Fariba Khodagholi Hadi Digaleh Fatemeh Shaerzadeh

NRF1

TFAM

10.1007/s10571-015-0236-0

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Citations (9)

Correlation among the Behavioral Features in the Offspring of Morphine-Abstinent Rats.

PubMed (2019)

Hamid Ahmadian-Moghadam Ardeshir Akbarabadi Heidar Toolee Mitra‐Sadat Sadat‐Shirazi Solmaz Khalifeh

Critical analysis of new evidence in medical sciences relies on statistics in terms of correlation. The aim of the present study was to evaluate the correlation coefficients among the behavioral features in the offspring of morphine-abstinent parent(s).

Positive correlation

Negative correlation

10.22122/ahj.v11i4.253

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Citations (3)