Yingran Xu

Anqing Normal University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Conghu Li

Anqing Normal University

Xu Cheng

Beijing Radiation Center

Chaochao Jia

Nanjing Tech University

Ting Hu

Huazhong University of Science and Technology

Bing Wei

Fuyang Normal University

Rupei Tang

Anhui University

Liwen Liu

Second Artillery General Hospital of Chinese People's Liberation Army

Shuiqin Shi

Anqing Normal University

Yong Zhang

The First People's Hospital of Guiyang

Zhuanzhuan Jiang

Anqing Normal University

Cooperative Institutions

Anqing Normal University

Anhui University

Sichuan University

University of Electronic Science and Technology of China

Chinese Academy of Sciences

Chongqing University of Science and Technology

North China Electric Power University

Tsinghua University

China International Science and Technology Cooperation

Chinese Academy of Medical Sciences & Peking Union Medical College

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

A sequentially responsive cascade nanoplatform for increasing chemo-chemodynamic therapy

Colloids and Surfaces B Biointerfaces (2022)

Xu Cheng Lu Wang Liwen Liu Shuiqing Shi Yingran Xu

Nanocarriers

PLGA

PEGylation

Hemin

Nanocapsules

10.1016/j.colsurfb.2022.113099

Cite

Citations (7)

Acid-sensitive and L61-crosslinked hyaluronic acid nanogels for overcoming tumor drug-resistance

International Journal of Biological Macromolecules (2021)

Xu Cheng Ting Hu Conghu Li Shuiqin Shi Yingran Xu

10.1016/j.ijbiomac.2021.08.004

Cite

Citations (14)

Glucose-Targeted Hydroxyapatite/Indocyanine Green Hybrid Nanoparticles for Collaborative Tumor Therapy

ACS Applied Materials & Interfaces (2021)

Xu Cheng Yingran Xu Yong Zhang Chaochao Jia Bing Wei

Nanoscale hydroxyapatite (nHA) is considered as a promising drug carrier or therapeutic agent against malignant tumors. But the strong agglomeration tendency and lack of active groups seriously hamper their usage in vivo. To address these issues, we fabricated an organic–inorganic hybrid nanosystem composed of poly(acrylic acid) (PAA), nHA, and indocyanine green (ICG), and further modified with glucose to give a targeting nanosystem (GA@HAP/ICG-NPs). These hybrid nanoparticles (∼90 nm) showed excellent storage and physiological stability assisted by PAA and had a sustained drug release in an acidic tumor environment. In vitro cell experiments confirmed that glucose-attached particles significantly promoted cellular uptake and increased intracellular ICG and Ca2+ concentrations by glucose transporter 1 (GLUT1)-mediated endocytosis. Subsequently, the excessive Ca2+ induced cell or organelle damage and ICG triggered photothermal and photodynamic effects (PTT/PDT) under laser irradiation, resulting in enhanced cell toxicity and apoptosis. In vivo tests revealed that the hybrid nanosystem possessed good hemocompatibility and biosafety, facilitating in vivo circulation and usage. NIR imaging further showed that tumor tissues had more drug accumulation, resulting in the highest tumor growth inhibition (87.89%). Overall, the glucose-targeted hybrid nanosystem was an effective platform for collaborative therapy and expected to be further used in clinical trials.

Indocyanine Green

10.1021/acsami.1c09852

Cite

Citations (21)

Dual-pH responsive chitosan nanoparticles for improving in vivo drugs delivery and chemoresistance in breast cancer

Carbohydrate Polymers (2022)

Qiang Chen Chaochao Jia Yingran Xu Zhuanzhuan Jiang Ting Hu

10.1016/j.carbpol.2022.119518

Cite

Citations (48)