Andrei Neagu

Carol Davila University of Medicine and Pharmacy

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Irina Lăpădat

Cristian‐Mihail Niculae

Carol Davila University of Medicine and Pharmacy

D. S. Miron

Carol Davila University of Medicine and Pharmacy

Adriana Hristea

National Institute of Research and Development for Biological Sciences

Constantin Mircioiu

Carol Davila University of Medicine and Pharmacy

E. Griu

Carol Davila University of Medicine and Pharmacy

George A. Călin

The University of Texas MD Anderson Cancer Center

A. Perju

Carol Davila University of Medicine and Pharmacy

Tudor Constantinescu

Carol Davila University of Medicine and Pharmacy

Olguța Corneli

Institutul Cantacuzino

Cooperative Institutions

Carol Davila University of Medicine and Pharmacy

University of Bucharest

Institutul de Pneumoftiziologie "Marius Nasta"

Clinical Emergency Hospital Bucharest

Max Planck Society

Romanian Academy

National Institute of Pathology

National Institute of Research and Development for Biological Sciences

Infectious Diseases Institute

Spitalul Clinic Colentina

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Novel insights into the antiproliferative effects and synergism of quercetin and menadione in human leukemia Jurkat T cells

Leukemia Research (2014)

Irina Băran Diana N. Ionescu Alexandru Filippi Maria‐Magdalena Mocanu Adrian Iftime

Jurkat cells

Menadione

10.1016/j.leukres.2014.04.010

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Pulmonary arterial hypertension and lung transplantation: when one severe pathology is replaced by another

Pneumologia (2022)

Andrei Neagu Tudor Constantinescu Claudia Toma Dragoș-Cosmin Zaharia Olguța Corneli

Abstract Pulmonary arterial hypertension (PAH) is a rare and severe disease characterised by the progressive narrowing of the small pulmonary arteries resulting in right-sided heart failure. Despite advances in treatment, some PAH patients require lung transplantation, which carries risks of long-term complications. We report the case of a male patient with no significant comorbidities, who developed progressive dyspnoea on exertion at the age of 38 years. After echocardiography and right heart catheterisation, he was confirmed with idiopathic PAH and was started treatment with bosentan, sildenafil and beraprost. After 3 years of stability, the PAH worsened. Treatment with continuous intravenous epoprostenol was introduced in a national premiere, unfortunately with little effect. The patient underwent lung transplantation at the age of 43 years. Afterwards, he developed several complications, including chronic lung allograft dysfunction, post-transplant lymphoproliferative disorder and pulmonary embolism. He died at the age of 52 years of invasive pulmonary aspergillosis. The case is noteworthy due to the above-average post-transplant survival despite multiple complications.

10.2478/pneum-2023-0014

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Pharmacokinetics of progesterone in postmenopausal women:

European Journal of Drug Metabolism and Pharmacokinetics (1998)

Constantin Mircioiu A. Perju Andrei Neagu E. Griu George A. Călin

10.1007/bf03192299

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Pharmacokinetics of progesterone in postmenopausal women

European Journal of Drug Metabolism and Pharmacokinetics (1998)

Constantin Mircioiu A. Perju E. Griu George A. Călin Andrei Neagu

Human physiology

Progesterone receptor

10.1007/bf03192300

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Challenges in the diagnosis of leptomeningeal dissemination of glioblastoma in a patient with fever and xanthochromic CSF: a case report

Research Square (Research Square) (2023)

Andrei Neagu Cristian‐Mihail Niculae Irina Lăpădat Adriana Hristea

Abstract Background Leptomeningeal spread with carcinomatous meningitis is a severe complication of glioblastoma, with a poor prognosis. Diagnosis is challenging, as the sensitivity of classic diagnostic investigations remains low for detecting cerebrospinal fluid (CSF) tumor spread and exclusion of infectious causes is mandatory, especially if unusual clinical findings are present. Case presentation A 71-year-old woman was admitted to our hospital for recurrent episodes of high fever and xanthochromic meningitis, with subacute onset. Her past medical history was significant for a left temporal glioblastoma, with adjuvant surgical and associated systemic immunosuppression, secondary to chemotherapy. An extensive workup especially with molecular microbiology testing for exclusion of infectious causes was performed. CSF was analyzed for typical bacterial and viral causes, but also pathogens associated with immunosuppression, such as Listeria monocytogenes and Cryptococcus neoformans. A therapeutic trial of standard antituberculous drugs with repeated lumbar punctures were needed in order to exclude Mycobacterium tuberculosis and to confirm the diagnosis of carcinomatous meningitis by cytopathological examination of the CSF. Conclusions The case describes an unusual clinical presentation of a patient with glioblastoma associated leptomeningeal dissemination, as high fever and xanthochromic CSF could raise important diagnostic and therapeutic challenges in the clinical practice. The diagnosis of carcinomatous meningitis requires an extensive workup for exclusion of infectious causes which is important for urgent oncologic treatment.

Immunosuppression

Viral meningitis

10.21203/rs.3.rs-2496974/v1

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Challenges in the diagnosis of leptomeningeal dissemination of glioblastoma in a patient with fever and xanthochromic CSF: a case report

Romanian Journal of Internal Medicine (2023)

Andrei Neagu Cristian‐Mihail Niculae Irina Lăpădat Adriana Hristea

Abstract Background Leptomeningeal spread with carcinomatous meningitis is a severe complication of glioblastoma, with a poor prognosis. Diagnosis is challenging, as the sensitivity of classic diagnostic investigations remains low for detecting cerebrospinal fluid (CSF) tumor spread and exclusion of infectious causes is mandatory, especially if unusual clinical findings are present. Case presentation A 71-year-old woman was admitted to our hospital for recurrent episodes of high fever and xanthochromic meningitis, with subacute onset. Her past medical history was significant for a left temporal glioblastoma, treated with surgical resection and adjuvant chemo- and radiotherapy, with associated systemic immunosuppression secondary to chemotherapy. An extensive workup especially with molecular microbiology testing for exclusion of infectious causes was performed. CSF was analyzed for typical bacterial and viral causes, but also pathogens associated with immunosuppression, such as Listeria monocytogenes and Cryptococcus neoformans. A therapeutic trial of standard antituberculous drugs with repeated lumbar punctures were needed in order to exclude Mycobacterium tuberculosis and to confirm the diagnosis of carcinomatous meningitis by cytopathological examination of the CSF. Conclusions The case describes an unusual clinical presentation of a patient with glioblastoma associated leptomeningeal dissemination, as high fever and xanthochromic CSF could raise important diagnostic and therapeutic challenges in the clinical practice. The diagnosis of carcinomatous meningitis requires an extensive workup for exclusion of infectious causes which is important for urgent oncologic treatment.

Immunosuppression

Viral meningitis

10.2478/rjim-2023-0010

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Citations (1)