Bioactive lipids involved in the progression of various diseases. Nevertheless, there is still a lack of biomarkers and relative regulatory targets. The lipidomic analysis of the samples from platinum-resistant in gastric cancer patients is expected to help us further improve our understanding of it.
Significance The translational GTPase LepA is a highly conserved bacterial protein whose role in the cell has been elusive. Here, we show that the function of LepA lies in biogenesis of the 30S subunit of the ribosome, rather than in translation elongation, as previously supposed. Loss of LepA results in the accumulation of immature 30S particles lacking certain proteins of the 3′ (head) domain and containing precursor 17S rRNA. The GTPase activity of LepA, like that of other translational GTPases, is stimulated by interactions with both subunits of the ribosome. This implies that LepA acts at a late stage of assembly, in the context of the 70S ribosome.
Mounting evidence indicates that the nervous system plays a central function in pathogenesis. To study the association of the nervous system in diseases, tools that allow delicate control of neural behavior are crucial. Wireless electrical modulation of neural cells via opto-stimulation is an emerging approach to trigger and control neural behavior. Furthermore, to imitate the highly organized natural neural network, neurite outgrowth needs to be guided to achieve directionality. This work successfully combines bionic fibers with nano-groove topography and evident opto-response to guide neurite outgrowth. With excellent biocompatibility, the bionic opto-responsive fibers spatiotemporally controlled and guided PC12 neurite outgrowth. Transient photocurrent measurement revealed that this effect was attributed to anodic faradaic photocurrents. This bionic opto-responsive fiber has great potential to act as a tool to control and guide neurite outgrowth to study nervous system/disease interaction.
Carbon dots (CDs), as a new type of photoluminescent nanomaterial, have attracted extensive attention in various fields because of their unique luminescence properties. However, CDs will exhibit fluorescence quenching in the solid state or aggregate state, which limits their application. In this paper, a unique strategy is proposed to regulate solutions to achieve multicolour fluorescence of CDs in the solid state. We report the successful preparation of orange, green and blue solid fluorescent CDs using citric acid, urea and phenylethylamine as precursors and methanol, ethanol and water as solvents, respectively. The solid-state fluorescence of CDs may be caused by the linkage of the phenylethyl structure to the surface of CDs during formation, which effectively disperses the CDs and prevents π-π interactions between graphitized nuclei. Meanwhile, multicolour solid fluorescent CDs are realized by adjusting the solvent in the preparation process. Based on the excellent fluorescence properties of CDs, orange, green and blue light-emitting diodes (LEDs) are prepared. A white LED (WLED) can be obtained by mixing the three colours of solid fluorescent CDs, which shows the application potential of CDs in display lighting equipment.
The influents/effluents from Calgary's water resource recovery facilities and the surface water were analyzed for pharmaceuticals in the present study. The median concentrations in the effluents for the 15 targeted pharmaceuticals were within the range of 0.006 to 3.32 ppb. Although the wastewater treatment facilities were not designed to remove pharmaceuticals, this study indicates that the wastewater treatment processes are effective in removing some of the pharmaceuticals from the aqueous phase. The removal rate estimated can be 99.5% for caffeine, whereas little or no removal was observed for carbamazepine. Biodegradation, chemical degradation, and sorption could be some of the mechanisms responsible for the removal of pharmaceuticals. The drug residues in downstream surface water could be associated with incomplete removal of pharmaceuticals during the treatment process and may lead to concerns in terms of potential impacts on the aquatic ecosystem. However, this study does not indicate any immediate risks to the downstream aquatic environment.
A fibrinogen based hydrogel scaffold provided 3D microenvironment for enhanced human mesenchymal stem cell proliferation, embedded connective tissue growth factor for directed fibrogenesis, and compliant substrate for alleviated myofibrogenesis.
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