Marina Franco Maggi Tavares

Universidade de São Paulo

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Gustavo Amadeu Micke

Universidade Federal de Santa Catarina

María Segunda Aurora‐Prado

Universidade de São Paulo

Fernando Gustavo Tonin

Universidade de São Paulo

Elisabete Alves Pereira

Universidade Federal de São Carlos

Gisele André Baptista Canuto

Universidade de São Paulo

ÉR

Érika Rosa Maria Kedor-Hackmann

Universidade de São Paulo

José Luiz Costa

Universidade Estadual de Campinas (UNICAMP)

Alessandra Vincenzi Jager

Universidade de São Paulo

María Inés Rocha Miritello Santoro

Universidade de São Paulo

Aline Klassen

Universidade Federal de São Paulo

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Universidade de São Paulo

188

Universidade Federal de São Paulo

Universidade Estadual de Campinas (UNICAMP)

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Universidade Brasil

Hospital Universitário da Universidade de São Paulo

Fundação de Apoio à Universidade Federal de São Paulo

Hospital Israelita Albert Einstein

Instituto de Ciências Farmacêuticas

Universidade Cidade de São Paulo

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Analysis of impurities in crude and highly-purified terephthalic acid by capillary electrophoresis

Journal of the Brazilian Chemical Society (2004)

Maria de Lourdes Leite de Moraes Joel C. Rubim Rene R. Realpozo Marina Franco Maggi Tavares

In this work, a simple and fast capillary electrophoresis method for the simultaneous analysis of 4-carboxybenzaldehyde (4-CBA), p-toluic acid (pTOL) and benzoic acid (BZ) in industrial batches of crude (CTA) and highly-purified (PTA) terephthalic acid was developed. The electrophoretic conditions comprise: 20 mmol L-1 tetraborate buffer at pH 9, hydrodynamic injection (5 s/17 kPa), applied voltage of +30 kV and direct UV detection at 200 nm. The concentrations of 4-CBA and pTOL in five batches of CTA and four batches of PTA as determined by the proposed CE methodology were in agreement with the results from gas chromatography and polarography methods in current use in Tereftalatos Mexicanos S.A. (TEMEX). Levels of BZ were determined only by the CE methodology and ranged from 60 - 300 ppm in CTA and 5 - 7 ppm in PTA. Several impurities deriving from the incomplete oxidation of p-xylene were investigated. So far the positive identification of 4-hydroxymethylbenzoic acid was accomplished by comparison with pure standards.

Benzoic acid

10.1590/s0103-50532004000300010

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Citations (12)

Current Efficiency and Electrogravimetric Determination of the Number of Electrons Involved in Galvanostatic Coulometry of Mercury Metal

Analytical Letters (1986)

Roberto Tokoro Marina Franco Maggi Tavares

Abstract The efficiency of current during the oxidation of mercury metal by galvanostatic coulometry was total in the presence of thiosulphate. The electrogravimetric determination of the number of electrons involved in the oxidation of metallic mercury in the presence of substances which have a great affinity for mercury ions, showed that n=2 in the electrochemical step. On the other hand, the mass variation was not a good method to determine n in the absence of complexing agent due to a coupled chemical process.

Coulometry

Mercury

Polarography

10.1080/00032718608080867

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Citations (3)

Determination of amino acids by capillary electrophoresis‐electrospray ionization‐mass spectrometry: An evaluation of different protein hydrolysis procedures

Electrophoresis (2008)

Ana Valéria Colnaghi Simionato Edgar P. Moraes Emanuel Carrilho Marina Franco Maggi Tavares Ernst Kenndler

Abstract In this work, a CE equipment, online hyphenated to an IT MS analyzer by a linear sheath liquid interface promoting ESI, was used to develop a method for quantitative determination of amino acids. Under appropriate conditions (BGE composition, 0.8% HCOOH, 20% CH 3 OH; sheath liquid composition, 0.8% HCOOH, 60% methanol; V ESI , +4.50 kV), analytical curves of all amino acids from 3 to 80 mg/L were recorded presenting acceptable linearity ( r >0.99). LODs in the range of 16–172 μmol/L were obtained. BSA, a model protein, was submitted to different hydrolysis procedures (classical acid and basic, and catalyzed by the H + form of a cation exchanger resin) and its amino acid profiles determined. In general, the resin‐mediated hydrolysis yields were overall similar or better than those obtained by classical acid or basic hydrolysis. The resulting experimental‐to‐theoretical BSA concentration ratios served as correction factors for the quantitation of amino acids in Brazil nut resin generated hydrolysates.

Capillary electrophoresis–mass spectrometry

10.1002/elps.200700629

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Citations (54)

Chemical identification of 2,5-dimethoxy-4-bromoamphetamine (DOB)

Forensic Science International (2007)

José Luiz Costa Alexandre Yautin Wang Gustavo Amadeu Micke Adriano O. Maldaner Renato Lahos Romano

Designer drug

10.1016/j.forsciint.2007.02.018

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Citations (15)

Anxiety-like effects of meta-chlorophenylpiperazine in paradoxically sleep-deprived mice

Progress in Neuro-Psychopharmacology and Biological Psychiatry (2013)

Daniel Ninello Polesel D.F. Fukushiro Mônica L. Andersen Karen Tieme Nozoe E. Mári-Kawamoto

Sleep

Privation

10.1016/j.pnpbp.2013.11.007

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Citations (6)

Theoretical Model of Electroosmotic Flow for Capillary Zone Electrophoresis

Analytical Chemistry (1995)

Marina Franco Maggi Tavares Victoria L. McGuffin

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTheoretical Model of Electroosmotic Flow for Capillary Zone ElectrophoresisMarina F. M. Tavares and Victoria L. McGuffinCite this: Anal. Chem. 1995, 67, 20, 3687–3696Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://doi.org/10.1021/ac00116a012RIGHTS & PERMISSIONSArticle Views351Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts

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Information flow

10.1021/ac00116a012

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Citations (43)

Reprogramming of Trypanosoma cruzi metabolism triggered by parasite interaction with the host cell extracellular matrix

PLoS neglected tropical diseases (2019)

Eliciane Cevolani Mattos Gisele André Baptista Canuto Nubia Carolina Manchola Rubens Daniel Miserani Magalhães Thomas W.M. Crozier

Trypanosoma cruzi, the etiological agent of Chagas' disease, affects 8 million people predominantly living in socioeconomic underdeveloped areas. T. cruzi trypomastigotes (Ty), the classical infective stage, interact with the extracellular matrix (ECM), an obligatory step before invasion of almost all mammalian cells in different tissues. Here we have characterized the proteome and phosphoproteome of T. cruzi trypomastigotes upon interaction with ECM (MTy) and the data are available via ProteomeXchange with identifier PXD010970. Proteins involved with metabolic processes (such as the glycolytic pathway), kinases, flagellum and microtubule related proteins, transport-associated proteins and RNA/DNA binding elements are highly represented in the pool of proteins modified by phosphorylation. Further, important metabolic switches triggered by this interaction with ECM were indicated by decreases in the phosphorylation of hexokinase, phosphofructokinase, fructose-2,6-bisphosphatase, phosphoglucomutase, phosphoglycerate kinase in MTy. Concomitantly, a decrease in the pyruvate and lactate and an increase of glucose and succinate contents were detected by GC-MS. These observations led us to focus on the changes in the glycolytic pathway upon binding of the parasite to the ECM. Inhibition of hexokinase, pyruvate kinase and lactate dehydrogenase activities in MTy were observed and this correlated with the phosphorylation levels of the respective enzymes. Putative kinases involved in protein phosphorylation altered upon parasite incubation with ECM were suggested by in silico analysis. Taken together, our results show that in addition to cytoskeletal changes and protease activation, a reprogramming of the trypomastigote metabolism is triggered by the interaction of the parasite with the ECM prior to cell invasion and differentiation into amastigotes, the multiplicative intracellular stage of T. cruzi in the vertebrate host.

Hexokinase

Phosphoglycerate kinase

10.1371/journal.pntd.0007103

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Citations (29)

Comparative evaluation of pre-concentration techniques for determination of impurities in atracurium besylate by capillary electrophoresis

Program and Abstracts (1999)

Maria de Lourdes Leite de Moraes Bronislaw Polakiewicz Marina Franco Maggi Tavares

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Development and validation of a capillary electrophoresis method for the determination of sulfate in indinavir sulfate raw material